ResLit - Antimicrobial Resistance Gene & Mutation Database

GenenimB

5-nitroimidazole reductase

Protein ChangeL155I

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: confers resistance
Resistance To: metronidazole
Organisms: Clostridioides difficile
Papers: 1

Paper Information1

Newly emerging metronidazole-resistant Clostridioides difficile PCR ribotype 955 identified in Poland, 2021 to 2023 but not in Czechia, 2012 to 2023 and Slovakia, 2015 to 2023.

PMID 40444372 · 2025

Mutations in the nimB gene and its promoter were associated with metronidazole resistance.

Mutation Information

nimB: p.L155I

Protein Change: L155I
Organisms: Clostridioides difficile
Confers Resistance To: metronidazole
Effect on Function: confers resistance
Validation Method: whole genome sequencing
Source Database: Reslit

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