ResLit - Antimicrobial Resistance Gene & Mutation Database

transcriptional regulator

Protein ChangeD191N

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: enhances DNA binding affinity and oligomerization, single resistance variant, response regulator transcription factor LiaR
Resistance To: daptomycin
Organisms: Enterococcus faecalis
Papers: 2

Paper Information2

Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance.

missense mutation

Enterococcus faecalis liaR mutant conferring daptomycin resistance; CARD accession: CARD:3003792

liaR

Protein Change: D191N
Organisms: Enterococcus faecalis
Confers Resistance To: daptomycin
Effect on Function: single resistance variant; response regulator transcription factor LiaR
Validation Method: whole-genome sequencing
Source Database: ReslitCard DatabaseReference Gene Catalog

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.

The D191N mutation enhances LiaR's DNA binding affinity and oligomerization, contributing to daptomycin resistance.

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