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Browse Mutations pbp2bT446A

penicillin-binding protein 2B

Nucleotide ChangeT446A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased MIC for piperacillin
Resistance To: piperacillin
Organisms: Streptococcus pneumoniae
Papers: 1

Paper Information1

1

Mechanism of β-Lactam Action in Streptococcus pneumoniae: the Piperacillin Paradox.

PMID 25385114 · 2015

Mutation Information

Nucleotide Change: T446A
Organisms: Streptococcus pneumoniae
Confers Resistance To: piperacillin
Effect on Function: increased MIC for piperacillin
Validation Method: mutagenesis and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research