ResLit - Antimicrobial Resistance Gene & Mutation Database

GenepmrA

polymyxin resistance

Protein ChangeE8D

Nucleotide ChangeGAG->GAT

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: constitutive expression of pmrA that leads to the up-regulation of the pmrCAB operon, and subsequent synthesis and addition of PEtN to the 4′-phosphate or 1′-phosphate of lipid A, two-component system response regulator PmrA
Resistance To: colistin
Organisms: Acinetobacter baumannii
Papers: 3

Paper Information3

Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France.

PMID 25583710 · 2015

Mutation Information

pmrA: p.E8D / c.GAG->GAT

Protein Change: E8D
Nucleotide Change: GAG->GAT
Confers Resistance To: colistin
Validation Method: genome sequencing and annotation
Source Database: Reslit

Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii.

PMID 29160808 · 2017

Mutation Information

pmrA: p.E8D

Protein Change: E8D
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Effect on Function: constitutive expression of pmrA that leads to the up-regulation of the pmrCAB operon, and subsequent synthesis and addition of PEtN to the 4′-phosphate or 1′-phosphate of lipid A
Validation Method: experimental validation in clinical isolates
Source Database: Reslit

Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections.

PMID 23812239 · 2013

pmrA

Mutation Information

pmrA: p.E8D

Protein Change: E8D
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Effect on Function: two-component system response regulator PmrA
Source Database: Reference Gene Catalog

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GenepmrA

polymyxin resistance

Protein ChangeE8D

Nucleotide ChangeGAG->GAT

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: constitutive expression of pmrA that leads to the up-regulation of the pmrCAB operon, and subsequent synthesis and addition of PEtN to the 4′-phosphate or 1′-phosphate of lipid A, two-component system response regulator PmrA
Resistance To: colistin
Organisms: Acinetobacter baumannii
Papers: 3

Paper Information3

Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France.

PMID 25583710 · 2015

Mutation Information

pmrA: p.E8D / c.GAG->GAT

Protein Change: E8D
Nucleotide Change: GAG->GAT
Confers Resistance To: colistin
Validation Method: genome sequencing and annotation
Source Database: Reslit

Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii.

PMID 29160808 · 2017

Mutation Information

pmrA: p.E8D

Protein Change: E8D
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Effect on Function: constitutive expression of pmrA that leads to the up-regulation of the pmrCAB operon, and subsequent synthesis and addition of PEtN to the 4′-phosphate or 1′-phosphate of lipid A
Validation Method: experimental validation in clinical isolates
Source Database: Reslit

Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections.

PMID 23812239 · 2013

pmrA

Mutation Information

pmrA: p.E8D

Protein Change: E8D
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Effect on Function: two-component system response regulator PmrA
Source Database: Reference Gene Catalog

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