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Browse Mutations pbp2bE476Q

penicillin-binding protein 2B

Protein ChangeE476Q

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: penicillin|cephalothin|cefoxitin
Papers: 1

Paper Information1

1

Commensal streptococci serve as a reservoir for β-lactam resistance genes in Streptococcus pneumoniae.

PMID 25845880 · 2015

Mutations in pbp2b are associated with reduced susceptibility to beta-lactam antibiotics.

Mutation Information

Protein Change: E476Q
Confers Resistance To: penicillin|cephalothin|cefoxitin
Validation Method: sequence analysis and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research