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Browse Mutations pmrAR81C

GenepmrA

polymyxin resistance

Protein ChangeR81C

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: two-component system response regulator PmrA
Resistance To: polymyxin b|colistin, colistin
Organisms: Salmonella enterica
Papers: 1

Paper Information1

1

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria.

PMID 25505462 · 2014

Mutations in pmrA lead to constitutive activation of the pmrA/pmrB system, resulting in increased resistance to polymyxins.

pmrA

Mutation Information

Protein Change: R81C
Organisms: Salmonella enterica
Confers Resistance To: polymyxin b|colistincolistin
Effect on Function: two-component system response regulator PmrA
Validation Method: mutation analysis
Source Database: ReslitReference Gene Catalog

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research