Browse AMR Mutations

Mutation Information

Protein Change

L143P

Organisms

Mycobacterium tuberculosis

Confers Resistance To

para aminosalicylic acid

Effect on Function

The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms.

Validation Method

molecular dynamics simulations and binding free energy analysis

Source Database

Reslit