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Browse Mutations acrBQ176K

GeneacrB

Acriflavin resistance protein B

Protein ChangeQ176K

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: increases binding energy for cefotaxime, improving recognition in the distal binding pocket, multidrug efflux RND transporter permease subunit AcrB
Resistance To: cefotaxime, cephalosporins
Organisms: Salmonella typhimurium, Salmonella enterica
Papers: 1

Paper Information1

1

Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles.

PMID 38686215 · 2023

both mutations enhance efflux efficiency

acrB

Mutation Information

Protein Change: Q176K
Organisms: Salmonella typhimurium, Salmonella enterica
Confers Resistance To: cefotaximecephalosporins
Effect on Function: increases binding energy for cefotaxime, improving recognition in the distal binding pocket; multidrug efflux RND transporter permease subunit AcrB
Validation Method: genetic complementation and MIC testing; enzyme docking and MIC testing
Source Database: ReslitReference Gene Catalog

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research