ResLit - Antimicrobial Resistance Gene & Mutation Database

penicillin-binding protein 2'

Nucleotide ChangeG-25A

Validation StatusCandidate

Databases

Reslit

Overview

Paper Information1

Role of the mecA Gene in Oxacillin Resistance in a Staphylococcus aureus Clinical Strain with a pvl-Positive ST59 Genetic Background.

Promoter mutations in the mecA gene significantly affect oxacillin resistance levels by altering PBP 2a production.

Nucleotide Change: G-25A
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillin
Validation Method: site-directed mutagenesis and assessment of PBP 2a production and oxacillin MICs
Source Database: Reslit

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