ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneampD

Anhydro-N-acetylmuramyl tripeptide amidase

Protein ChangeW95L

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: The Trp95Leu substitution was predicted to weaken ligand binding, likely affecting the positioning of the ligand in the active site.
Resistance To: ertapenem|imipenem|meropenem
Organisms: Klebsiella aerogenes
Papers: 1

Paper Information1

Next-Generation-Sequencing-Based Hospital Outbreak Investigation Yields Insight into Klebsiella aerogenes Population Structure and Determinants of Carbapenem Resistance and Pathogenicity.

PMID 30910904 · 2019

Mutation Information

ampD: p.W95L

Protein Change: W95L
Organisms: Klebsiella aerogenes
Confers Resistance To: ertapenem|imipenem|meropenem
Effect on Function: The Trp95Leu substitution was predicted to weaken ligand binding, likely affecting the positioning of the ligand in the active site.
Validation Method: Whole-genome sequencing and functional analysis
Source Database: Reslit

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