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Browse Mutations sul2F179G

Genesul2

sulfonamide resistance

Protein ChangeF179G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduces sulfa binding affinity
Resistance To: sulfamethoxazole|sulfadiazine|sulfisoxazole
Organisms: Escherichia coli, Salmonella enterica
Papers: 1

Paper Information1

1

Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.

PMID 37419898 · 2023

Phe179Gly substitution reduces sulfa binding affinity

Mutation Information

Protein Change: F179G
Organisms: Escherichia coli, Salmonella enterica
Confers Resistance To: sulfamethoxazole|sulfadiazine|sulfisoxazole
Effect on Function: reduces sulfa binding affinity
Validation Method: kinetic analysis and susceptibility testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research