ResLit - Antimicrobial Resistance Gene & Mutation Database

5-nitroimidazole reductase

Nucleotide ChangeT-10G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: constitutive expression of nimB, resulting in metronidazole resistance
Resistance To: metronidazole
Organisms: Clostridioides difficile
Papers: 1

Paper Information1

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile.

The P nimB G mutation leads to constitutive expression of nimB, resulting in metronidazole resistance.

Nucleotide Change: T-10G
Organisms: Clostridioides difficile
Confers Resistance To: metronidazole
Effect on Function: constitutive expression of nimB, resulting in metronidazole resistance
Validation Method: genome sequencing and qRT-PCR
Source Database: Reslit

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