ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemtrR

transcriptional repressor

Nucleotide ChangeC2611T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased expression of the efflux pump
Resistance To: azithromycin
Organisms: Neisseria gonorrhoeae
Papers: 1

Paper Information1

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae.

PMID 30087172 · 2018

Mutations in mtrR contribute to increased resistance when combined with mtrD mutations.

Mutation Information

mtrR: c.C2611T

Nucleotide Change: C2611T
Organisms: Neisseria gonorrhoeae
Confers Resistance To: azithromycin
Effect on Function: increased expression of the efflux pump
Validation Method: sequencing and MIC testing
Source Database: Reslit

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