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Browse Mutations walKD274A

GenewalK

histidine kinase

Protein ChangeD274A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: gain-of-function
Resistance To: cef
Organisms: Bacillus subtilis
Papers: 1

Paper Information1

1

A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs.

PMID 32897856 · 2020

Gain-of-function mutation in walK suppresses synthetic lethality and confers resistance to CEF

Mutation Information

Protein Change: D274A
Organisms: Bacillus subtilis
Confers Resistance To: cef
Effect on Function: gain-of-function
Validation Method: spot dilution assay
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research