ResLit - Antimicrobial Resistance Gene & Mutation Database

GenepenA

penicillin-binding protein 2 (PBP 2)

Protein ChangeD346A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: lowered the acylation rate of penicillin G by 5-fold
Resistance To: penicillin
Organisms: Neisseria gonorrhoeae
Papers: 1

Paper Information1

A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: mutational and computational analysis of PBP 2 from N. gonorrhoeae.

PMID 22397678 · 2012

Mutations in penA affect the interaction between Asp346 and Ser363, impacting TPase activity and penicillin resistance.

Mutation Information

penA: p.D346A

Protein Change: D346A
Organisms: Neisseria gonorrhoeae
Confers Resistance To: penicillin
Effect on Function: lowered the acylation rate of penicillin G by 5-fold
Validation Method: proteolytic susceptibility and transformation experiments
Source Database: Reslit

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