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Browse Mutations sigAR515H

GenesigA

Protein ChangeR515H

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disrupting, knocking out, or mutating the gene causes SUSCEPTIBILITY
Resistance To: spectinomycin|tetracycline|clarithromycin
Organisms: Mycobacterium smegmatis
Papers: 1

Paper Information1

1

The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV).

PMID 23990327 · 2013

Mutation Information

Protein Change: R515H
Organisms: Mycobacterium smegmatis
Confers Resistance To: spectinomycin|tetracycline|clarithromycin
Effect on Function: disrupting, knocking out, or mutating the gene causes SUSCEPTIBILITY
Validation Method: mutant construction and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research