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Browse Mutations ddlF260Y

Geneddl

d-Ala-d-Ala ligase

Protein ChangeF260Y

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increases vancomycin sensitivity
Resistance To: vancomycin
Organisms: Lactobacillus plantarum
Papers: 1

Paper Information1

1

d-Alanyl-d-Alanine Ligase as a Broad-Host-Range Counterselection Marker in Vancomycin-Resistant Lactic Acid Bacteria.

PMID 29686137 · 2018

Mutations in Ddl lead to decreased vancomycin resistance by altering peptidoglycan structure.

Mutation Information

Protein Change: F260Y
Organisms: Lactobacillus plantarum
Confers Resistance To: vancomycin
Effect on Function: increases vancomycin sensitivity
Validation Method: Plasmid expression in L. plantarum and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research