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Browse Mutations clpC1K209E

ATP-dependent ATPase

Protein ChangeK209E

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: impairs PanD degradation
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Papers: 1

Paper Information1

1

Pyrazinamide triggers degradation of its target aspartate decarboxylase.

PMID 32245967 · 2020

Mutations in clpC1 confer resistance to pyrazinamide by impairing PanD degradation.

Mutation Information

Protein Change: K209E
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Confers Resistance To: pyrazinamide
Effect on Function: impairs PanD degradation
Validation Method: fluorescence reporter assays and western blotting
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research