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Browse Mutations thyAE58Q

GenethyA

folate-dependent thymidylate synthase

Protein ChangeE58Q

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: trimethoprim sulfamethoxazole
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection.

PMID 35802671 · 2022

found in all TMP-SMX resistant isolates

Mutation Information

Protein Change: E58Q
Organisms: Escherichia coli
Confers Resistance To: trimethoprim sulfamethoxazole
Validation Method: whole genome sequencing and growth experiments
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research