ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeD179Y

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: confers resistance to ceftazidime/avibactam without loss of carbapenem resistance
Resistance To: ceftazidime avibactam
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two bla(KPC-2) gene copies without losing carbapenem resistance.

PMID 36118031 · 2022

The D179Y mutation in one of the two bla(KPC-2) gene copies leads to resistance to ceftazidime/avibactam without loss of carbapenem resistance.

Mutation Information

bla(KPC-2): p.D179Y

Protein Change: D179Y
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftazidime avibactam
Effect on Function: confers resistance to ceftazidime/avibactam without loss of carbapenem resistance
Validation Method: PCR confirmation and genomic analysis
Source Database: Reslit

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