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Browse Mutations blaKPCK167R

carbapenem-hydrolyzing beta-lactamase

Protein ChangeK167R

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased susceptibility to β-lactams, including the carbapenems, and meropenem-vaborbactam (MEM-VAB)
Resistance To: imipenem relebactam|ceftazidime avibactam
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

In Vitro Mechanisms of Resistance Development to Imipenem-Relebactam in KPC-Producing Klebsiella pneumoniae.

PMID 36154170 · 2022

Mutations in blaKPC lead to reduced susceptibility to imipenem-relebactam and ceftazidime-avibactam.

Mutation Information

blaKPC: p.K167R

Protein Change: K167R
Organisms: Klebsiella pneumoniae
Confers Resistance To: imipenem relebactam|ceftazidime avibactam
Effect on Function: decreased susceptibility to β-lactams, including the carbapenems, and meropenem-vaborbactam (MEM-VAB)
Validation Method: cloning and enzyme kinetic assays
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research