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Browse Mutations mtrRA-24C

GenemtrR

transcriptional repressor

Nucleotide ChangeA-24C

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased MtrCDE efflux of substrate antimicrobials
Resistance To: azithromycin
Organisms: Neisseria gonorrhoeae
Papers: 1

Paper Information1

1

Impact of mutations in the mtrR, rpdlVD and rrl genes on azithromycin resistance in Neisseria gonorrhoeae.

PMID 39012901 · 2024

The A->C substitution in the mtrR promoter was significantly associated with MIC values ≥1 mg/L.

Mutation Information

Nucleotide Change: A-24C
Organisms: Neisseria gonorrhoeae
Confers Resistance To: azithromycin
Effect on Function: increased MtrCDE efflux of substrate antimicrobials
Validation Method: sequencing and MIC analysis
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research