ResLit - Antimicrobial Resistance Gene & Mutation Database

GenepilQ

Type IV pilus secretin

Protein ChangeE666K

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseResFinder DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: cefixime|penicillin, penicillin|tetracycline|ciprofloxacin, beta lactams
Organisms: Neisseria gonorrhoeae
Papers: 3

Paper Information3

WGS to predict antibiotic MICs for Neisseria gonorrhoeae.

PMID 28333355 · 2017

Mutation Information

pilQ: p.E666K

Protein Change: E666K
Confers Resistance To: cefixime|penicillin
Validation Method: WGS and multivariate linear regression models
Source Database: Reslit

Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.

PMID 24982323 · 2014

Only effective in the presents of the mtrR and penB (porB mutation) resistance determinants

Mutation Information

pilQ: p.E666K

Protein Change: E666K
Organisms: Neisseria gonorrhoeae
Confers Resistance To: penicillin|tetracycline|ciprofloxacin
Source Database: ResFinder Database

The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability.

PMID 16101998 · 2005

Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam; CARD accession: CARD:3004835

Mutation Information

pilQ: p.E666K

Protein Change: E666K
Organisms: Neisseria gonorrhoeae
Confers Resistance To: beta lactams
Effect on Function: single resistance variant
Source Database: Card Database

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