ResLit - Antimicrobial Resistance Gene & Mutation Database

Genecls

cardiolipin synthetase

Protein ChangeK59T

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene Catalog

Overview

Mechanism: single resistance variant, cardiolipin synthase Cls
Resistance To: daptomycin
Organisms: Enterococcus faecium
Papers: 1

Paper Information1

Evolution of high-level daptomycin resistance in Enterococcus faecium during daptomycin therapy is associated with limited mutations in the bacterial genome.

PMID 23580562 · 2013

Enterococcus faecium cls conferring resistance to daptomycin; CARD accession: CARD:3003092

Mutation Information

cls: p.K59T

Protein Change: K59T
Organisms: Enterococcus faecium
Confers Resistance To: daptomycin
Effect on Function: single resistance variant
Source Database: Card Database

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