ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneampC

beta-lactamase

Protein ChangeA201T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: enhanced cephalosporin resistance
Resistance To: ceftazidime|ceftolozane
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Selection of AmpC β-Lactamase Variants and Metallo-β-Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections.

PMID 34930034 · 2022

These mutations are in the AmpC β-lactamase gene and contribute to resistance to ceftazidime and ceftolozane.

Mutation Information

ampC: p.A201T

Protein Change: A201T
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftazidime|ceftolozane
Effect on Function: enhanced cephalosporin resistance
Validation Method: genomic analysis and sequencing
Source Database: Reslit

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