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Browse Mutations gyrBE512D

GenegyrB

Protein ChangeE512D

Nucleotide ChangeG1537T

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: fluoroquinolones
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.

PMID 17938193 · 2007

Detected in mice treated with 0.25% MXF

Mutation Information

gyrB: p.E512D / c.G1537T

Protein Change: E512D
Nucleotide Change: G1537T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: fluoroquinolones
Validation Method: sequencing of resistant isolates
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research