ResLit - Antimicrobial Resistance Gene & Mutation Database

GenegyrA

Protein ChangeR140K

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: multiple resistance variants
Resistance To: levofloxacin|moxifloxacin|ciprofloxacin, fluoroquinolones
Organisms: Helicobacter pylori
Papers: 2

Paper Information2

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

gyrA: p.R140K

Protein Change: R140K
Organisms: Helicobacter pylori
Confers Resistance To: levofloxacin|moxifloxacin|ciprofloxacin
Validation Method: PCR and sequencing
Source Database: Reslit

Surveillance of Helicobacter pylori Antibiotic Susceptibility in Indonesia: Different Resistance Types among Regions and with Novel Genetic Mutations.

PMID 27906990 · 2016

Helicobacter pylori gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3007052

Mutation Information

gyrA: p.R140K

Protein Change: R140K
Organisms: Helicobacter pylori
Confers Resistance To: fluoroquinolones
Effect on Function: multiple resistance variants
Source Database: Card Database

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