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Browse Mutations gyrBR482K

GenegyrB

Protein ChangeR482K

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: The R482 side chain is located in the minor groove and forms a gate which blocks the quinolone in the pocket
Resistance To: fluoroquinolones
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.

PMID 20805881 · 2010

R482K mutation contributes to intrinsic quinolone resistance

Mutation Information

Protein Change: R482K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: fluoroquinolones
Effect on Function: The R482 side chain is located in the minor groove and forms a gate which blocks the quinolone in the pocket
Validation Method: structural modeling and previous studies
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research