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Browse Mutations gyrAR38L

GenegyrA

Protein ChangeR38L

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disruption of DNA gyrase function
Resistance To: fluoroquinolones
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.

PMID 28223393 · 2017

Mutations in gyrA confer resistance to fluoroquinolones.

Mutation Information

Protein Change: R38L
Organisms: Escherichia coli
Confers Resistance To: fluoroquinolones
Effect on Function: disruption of DNA gyrase function
Validation Method: whole-genome sequencing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research