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Browse Mutations pmrBS253L

GenepmrB

Protein ChangeS253L

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: colistin
Organisms: Acinetobacter nosocomialis
Papers: 1

Paper Information1

1

Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis.

PMID 34468294 · 2021

The Ser253Leu substitution in PmrB was shown to contribute to colistin resistance through increased pmrCAB operon expression.

Mutation Information

Protein Change: S253L
Organisms: Acinetobacter nosocomialis
Confers Resistance To: colistin
Validation Method: introducing recombinant PmrB constructs into a PmrB knockout strain and protein structural model analyses
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research