Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
two-component system sensor kinase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A262P | - | constitutive activation | Acinetobacter baumannii | colistin | Reslit | Candidate |
| A227V | - | constitutive activation, two-component system sensor histidine kinase PmrB | Acinetobacter baumannii, Klebsiella pneumoniae | colistinpolymyxin bpolymyxin b|colistin | ReslitReference Gene Catalog | Candidate |
| T13N | - | constitutive activation | Acinetobacter baumannii | colistin | Reslit | Candidate |
| P233S | constitutive activation, associated with stable resistance, two-component system sensor histidine kinase PmrB | Acinetobacter baumannii, A. baumannii | colistinpolymyxins | ReslitReference Gene Catalog | Candidate | |
| P233T | - | constitutive activation, two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | ReslitReference Gene Catalog | Candidate |
| M145K | - | disruption of pmrB leads to increased susceptibility to colistin | Acinetobacter baumannii | colistin | Reslit | Candidate |
| T235I | - | associated with stable resistance, two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | polymyxin bcolistin | ReslitReference Gene Catalog | Candidate |
| G315D | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | polymyxin bcolistin | ReslitReference Gene Catalog | Candidate |
| R263P | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| Q277H | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| M12I | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| R231L | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | polymyxin bcolistin | ReslitReference Gene Catalog | Candidate |
| T7I | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| A211V | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| F90L | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| P360Q | - | Acinetobacter baumannii | polymyxin bcolistin | Reslit | Candidate | |
| L14P | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| P456S | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| A95T | - | gain-of-function | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| T253M | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| A248T | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| A54V | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| R79H | - | gain-of-function | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| R259H | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| R135Q | - | gain-of-function | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| M292I | - | gain-of-function | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| G188D | - | gain-of-function, alteration of the HAMP domain, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistinpolymyxin b | ReslitReference Gene Catalog | Candidate |
| L243Q | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| A248V | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| S257N | - | gain-of-function, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| R57H | - | gain-of-function | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| G52D | - | gain-of-function | Pseudomonas aeruginosa | polymyxin b | Reslit | Candidate |
| M292T | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | polymyxin bcolistin | ReslitReference Gene Catalog | Candidate |
| A247T | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | polymyxin bcolistin | ReslitReference Gene Catalog | Candidate |
| Y345H | - | - | Pseudomonas aeruginosa | polymyxin bpolymyxinscolistin | Reslit | Candidate |
| T157P | - | constitutive activation of PmrA, deleterious, mutant pmrB gene leads to activation of the pmrHFIJKLM operon, which modifies lipopolysaccharide (LPS) with 4-amino-4-deoxy-L-arabinose (L-Ara4N) or phosphoethanolamine (pEtN), deleterious to protein structure/function, two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | colistinpolymyxinscarbapenems+1 more | ReslitReference Gene Catalog | Candidate |
| L14S | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistinpolymyxinscolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| L14F | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| L22P | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistinpolymyxinscolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| S29R | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| T92A | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistinpolymyxinscolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| P94Q | - | affects protein function, Target modification, two-component system sensor histidine kinase PmrB | E. coli, Salmonella enterica, Escherichia coli | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| E121A | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| S124P | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| N130Y | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| T147P | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella Mississippi, Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| R155P | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| T156P | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| T156M | - | Target modification, two-component system sensor histidine kinase PmrB | E. coli, Salmonella enterica, Escherichia coli | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| V161M | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| V161L | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| V161G | Target modification, two-component system sensor histidine kinase PmrB | Escherichia coli, E. coli, Chicken (M), Human (M), Farm Chicken, Market Chicken, Poultry Farm, Poultry Market, Salmonella enterica | polymyxin b|colistincolistinpolymyxin b | ReslitResFinder DatabaseReference Gene Catalog | Candidate | |
| E166K | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica, Escherichia coli | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| M186I | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| G206W | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| G206R | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| S305R | - | Target modification, two-component system sensor histidine kinase PmrB | Salmonella enterica | polymyxin b|colistincolistin | ReslitResFinder DatabaseReference Gene Catalog | Candidate |
| V9A | - | constitutive activity, two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| A118T | - | - | Escherichia coli | colistin | Reslit | Candidate |
| E123D | - | - | Escherichia coli | colistin | Reslit | Candidate |
| Y315F | - | - | Escherichia coli | colistin | Reslit | Candidate |
| Y358N | - | - | Escherichia coli, E. coli | colistin | Reslit | Candidate |
| G206D | - | gain-of-function, two-component system sensor histidine kinase PmrB | Escherichia coli, Salmonella spp. | colistin | ReslitReference Gene Catalog | Candidate |
| T132A | - | - | Pseudomonas aeruginosa | polymyxins | Reslit | Candidate |
| T92P | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | ReslitReference Gene Catalog | Candidate |
| G151D | - | - | Escherichia coli | colistin | Reslit | Candidate |
| V164M | - | predicted to affect the function of PmrB based on SIFT score (<0.05) | Salmonella enterica, Escherichia coli | colistin | Reslit | Candidate |
| V164G | - | - | Salmonella enterica | colistin | Reslit | Candidate |
| R92P | - | - | Salmonella enterica | colistin | Reslit | Candidate |
| G423C | - | resistance | Pseudomonas aeruginosa | amikacin | Reslit | Candidate |
| V386M | - | - | Pseudomonas aeruginosa | polymyxins | Reslit | Candidate |
| L213M | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| T246A | - | enhanced ATP binding affinity and protein stability | Klebsiella pneumoniae | colistinpolymyxin bpolymyxins | Reslit | Candidate |
| N353I | - | increases the expression of the pmrC | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| A138S | - | - | - | colistin | Reslit | Candidate |
| R256G | - | deleterious, mutation in pmrB gene | Klebsiella pneumoniae, Providencia stuartii | colistinpolymyxin bpolymyxins | Reslit | Candidate |
| V9I | - | - | - | polymyxins | Reslit | Candidate |
| I216T | - | - | - | polymyxins | Reslit | Candidate |
| Q344P | - | - | - | polymyxins | Reslit | Candidate |
| F204L | - | - | Klebsiella pneumoniae | polymyxin b | Reslit | Candidate |
| S253L | - | - | Acinetobacter nosocomialis | colistin | Reslit | Candidate |
| H89L | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| D313N | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae, Acinetobacter baumannii | colistinpolymyxins | ReslitReference Gene Catalog | Candidate |
| T235N | - | - | Escherichia coli, Acinetobacter baumannii | colistin | Reslit | Candidate |
| D283G | - | - | Escherichia coli | colistin | Reslit | Candidate |
| V351I | - | - | Escherichia coli | colistin | Reslit | Candidate |
| V285L | - | - | Pseudomonas aeruginosa | tobramycin | Reslit | Candidate |
| P175S | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| A236E | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| T114I | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| T4A | - | activating mutation | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| L323H | - | activating mutation | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| G256R | - | - | Klebsiella pneumoniae | colistinpolymyxins | Reslit | Candidate |
| D150V | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L237R | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| G250C | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| A252G | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| H267P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| R315P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| Q331H | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| N105K | - | - | Klebsiella pneumoniae | polymyxins | Reslit | Candidate |
| H440N | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| L10G | - | - | E. coli | colistin | Reslit | Candidate |
| C84Y | - | two-component system sensor histidine kinase PmrB | E. coli, Escherichia coli | colistin | ReslitReference Gene Catalog | Candidate |
| D149Y | - | - | E. coli | colistin | Reslit | Candidate |
| T156K | - | - | E. coli | colistin | Reslit | Candidate |
| A159V | - | two-component system sensor histidine kinase PmrB | E. coli, Escherichia coli | colistin | ReslitReference Gene Catalog | Candidate |
| S2P | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| A138T | destabilizing | Acinetobacter baumannii, A. baumannii | colistinpolymyxin b | Reslit | Candidate | |
| P200L | - | - | - | colistin | Reslit | Candidate |
| E229D | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| D150H | - | - | - | colistin | Reslit | Candidate |
| S203P | - | - | Klebsiella pneumoniae | colistinpolymyxins | Reslit | Candidate |
| M285L | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| H2R | - | - | Escherichia coli | colistin | Reslit | Candidate |
| A360V | - | - | Escherichia coli | colistin | Reslit | Candidate |
| L9P | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| I25F | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| F155V | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| E185K | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| F387Y | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| N353S | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| T128P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| P170T | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| R263H | - | Acinetobacter baumannii | polymyxin bcolistin | Reslit | Candidate | |
| N353Y | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| P170L | associated with stable resistance, nonsynonymous mutation, two-component system sensor histidine kinase PmrB | Acinetobacter baumannii, Acinetobacter pittii, Acinetobacter seifertii | polymyxin bcolistin | ReslitReference Gene Catalog | Candidate | |
| F164I | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| A412V | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| P175L | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| P254L | - | - | Pseudomonas aeruginosa | gentamicin|streptomycin | Reslit | Candidate |
| V136E | - | - | Pseudomonas aeruginosa | gentamicin|streptomycingentamicin | Reslit | Candidate |
| K21S | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| S28R | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| T232I | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | polymyxin bcolistin | ReslitReference Gene Catalog | Candidate |
| G22E | - | - | Escherichia coli | colistin | Reslit | Candidate |
| E126D | - | - | Escherichia coli | colistin | Reslit | Candidate |
| D315N | - | - | Escherichia coli | colistin | Reslit | Candidate |
| V28G | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| L10R | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | ReslitReference Gene Catalog | Candidate |
| L10P | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | ReslitReference Gene Catalog | Candidate |
| T156A | - | - | - | colistin | Reslit | Candidate |
| A246T | - | - | Klebsiella pneumoniae | colistinpolymyxins | Reslit | Candidate |
| M213L | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| Q270P | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | ReslitReference Gene Catalog | Candidate | |
| L344P | - | enhanced ATP binding affinity and protein stability | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| D150Y | - | - | Klebsiella pneumoniae | polymyxins | Reslit | Candidate |
| H345Y | - | - | Pseudomonas aeruginosa | polymyxin b|colistin | Reslit | Candidate |
| V15I | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | ReslitReference Gene Catalog | Candidate |
| L18P | - | confers resistance to colistin | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| L17P | - | confers resistance to colistin | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| D47G | - | confers resistance to colistin | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| L243R | - | confers resistance to colistin | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| F408L | - | confers resistance to colistin | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| G188S | - | alteration of the HAMP domain | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| V136L | - | disruption of the two-component regulatory system | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| T132P | - | disruption of the two-component regulatory system | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| R155H | - | disruption of the two-component regulatory system | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| A330P | - | disruption of the two-component regulatory system | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| L274W | - | - | A. baumannii | colistin | Reslit | Candidate |
| Q43L | - | - | A. baumannii | colistin | Reslit | Candidate |
| L267F | - | - | A. baumannii | colistin | Reslit | Candidate |
| A226V | - | - | A. baumannii, Acinetobacter baumannii | colistin | Reslit | Candidate |
| Q277R | - | - | A. baumannii | colistin | Reslit | Candidate |
| L17R | - | predicted to affect the function of PmrB based on SIFT score (<0.05) | Escherichia coli | colistin | Reslit | Candidate |
| C340F | - | mutant PmrB leads to cross-resistance to aminoglycosides and colistin | Pseudomonas aeruginosa | polymyxin b | Reslit | Candidate |
| S138N | - | - | Escherichia coli | colistin | Reslit | Candidate |
| L339C | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| H340I | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| N341T | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| R342D | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| Q343S | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| P346Q | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| M15T | - | - | Salmonella spp. | polymyxin b|colistin | Reslit | Candidate |
| G73S | - | - | Salmonella spp. | polymyxin b|colistin | Reslit | Candidate |
| V74I | - | - | Salmonella spp. | polymyxin b|colistin | Reslit | Candidate |
| I83A | - | - | Salmonella spp. | polymyxin b|colistin | Reslit | Candidate |
| A111V | - | - | Salmonella spp. | polymyxin b|colistin | Reslit | Candidate |
| T140P | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | colistin | ReslitReference Gene Catalog | Candidate |
| T240M | - | - | - | colistin | Reslit | Candidate |
| L82R | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | colistinpolymyxins | ReslitReference Gene Catalog | Candidate |
| M308R | - | associated with HR to colistin | Acinetobacter baumannii | colistin | Reslit | Candidate |
| A226T | - | associated with stable resistance, two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | ReslitReference Gene Catalog | Candidate |
| S403F | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| R263C | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| T13A | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| S17G | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| M308T | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| P170Q | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| L5S | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| R207C | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| G426S | - | - | Acinetobacter baumannii, Klebsiella pneumoniae | colistin | Reslit | Candidate |
| P344L | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| G273D | - | - | Enterobacter cloacae | colistin | Reslit | Candidate |
| G123A | - | - | Pseudomonas aeruginosa | polymyxins | Reslit | Candidate |
| N5K | - | - | Acinetobacter junii | colistin | Reslit | Candidate |
| T269P | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| K6I | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| L160F | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| I19F | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| F103L | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| I163N | - | - | Acinetobacter baumannii | colistinpolymyxin b | Reslit | Candidate |
| I164F | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | ReslitReference Gene Catalog | Candidate |
| S183F | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| T232A | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| Q265P | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| H266Y | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| G315V | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| R263S | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| G19R | - | - | Escherichia coli | colistin | Reslit | Candidate |
| S85R | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | polymyxin bpolymyxinscolistin | ReslitReference Gene Catalog | Candidate |
| P95L | deleterious | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| I361L | - | - | Escherichia coli | colistin | Reslit | Candidate |
| G54E | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| L189Q | - | - | Pseudomonas aeruginosa | polymyxin b | Reslit | Candidate |
| V162A | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| E121K | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | ReslitReference Gene Catalog | Candidate |
| G260D | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| L135P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| N268Y | - | associated with TG resistance | Acinetobacter baumannii | colistin | Reslit | Candidate |
| F456L | - | - | - | colistin | Reslit | Candidate |
| T134P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| T89P | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| D21A | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| P14L | - | - | Escherichia coli | colistin | Reslit | Candidate |
| K121E | - | - | Escherichia coli | colistin | Reslit | Candidate |
| R345Q | - | - | - | colistin | Reslit | Candidate |
| L108Q | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| G207D | - | deleterious | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| D133G | - | - | Acinetobacter baumannii | polymyxins | Reslit | Candidate |
| E161K | - | - | Acinetobacter baumannii | polymyxins | Reslit | Candidate |
| A444V | - | destabilizing | Acinetobacter baumannii | colistin | Reslit | Candidate |
| G123R | - | - | - | polymyxins | Reslit | Candidate |
| M145I | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| S17R | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | ReslitReference Gene Catalog | Candidate |
| R263L | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | ReslitReference Gene Catalog | Candidate |
| Y116H | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| L271R | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| L206P | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| G272D | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| P158R | - | - | Klebsiella pneumoniae | polymyxin b|colistin | Reslit | Candidate |
| A256G | - | deleterious | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| S14P | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| F26L | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| S61G | - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate |
| V27H | - | - | - | polymyxins | Reslit | Candidate |
| P103W | - | - | - | polymyxins | Reslit | Candidate |
| C395A | - | - | - | polymyxins | Reslit | Candidate |
| H61Q | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| V280L | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| T296S | - | altered | Klebsiella aerogenes | colistin | Reslit | Candidate |
| V352E | - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate |
| R10L | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| T158I | - | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate |
| S363I | - | - | Klebsiella pneumoniae, Klebsiella quasipneumoniae | colistin | Reslit | Candidate |
| S175I | - | - | Enterobacter cloacae | colistin | Reslit | Candidate |
| R81C | - | Target modification | Salmonella enterica | colistin | ResFinder Database | Candidate |
| R81H | - | Target modification | Salmonella enterica | colistin | ResFinder Database | Candidate |
| L168K | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | Reference Gene Catalog | Candidate |
| E301G | - | two-component system sensor histidine kinase PmrB | Acinetobacter baumannii | colistin | Reference Gene Catalog | Candidate |
| RPISLR6del | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| L14Q | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| L14R | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| C84R | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| P94A | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| P94L | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| P94S | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| E121Q | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| T147A | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| A159P | - | two-component system sensor histidine kinase PmrB | Escherichia coli | colistin | Reference Gene Catalog | Candidate |
| R14del | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Candidate |
| L17Q | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae, Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Candidate |
| ALNQLV129del | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Candidate |
| S208N | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Candidate |
| Y209del | - | two-component system sensor histidine kinase PmrB | Klebsiella pneumoniae | colistin | Reference Gene Catalog | Candidate |
| D47del | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Candidate |
| L167P | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Candidate |
| S257D | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Candidate |
| V281I | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Candidate |
| H340R | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Candidate |
| T343A | - | two-component system sensor histidine kinase PmrB | Pseudomonas aeruginosa | colistin | Reference Gene Catalog | Candidate |
| RQRL11del | - | two-component system sensor histidine kinase PmrB | Salmonella enterica | colistin | Reference Gene Catalog | Candidate |
| R89P | - | two-component system sensor histidine kinase PmrB | Salmonella enterica | colistin | Reference Gene Catalog | Candidate |
| T147S | - | two-component system sensor histidine kinase PmrB | Salmonella enterica | colistin | Reference Gene Catalog | Candidate |
| F203S | - | two-component system sensor histidine kinase PmrB | Salmonella enterica | colistin | Reference Gene Catalog | Candidate |
| G206E | - | two-component system sensor histidine kinase PmrB | Salmonella enterica | colistin | Reference Gene Catalog | Candidate |
| D250Y | - | two-component system sensor histidine kinase PmrB | Salmonella enterica | colistin | Reference Gene Catalog | Candidate |
| - | - | Pseudomonas aeruginosa | gentamicin | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | gentamicin | Reslit | Candidate | |
| - | confers resistance to polymyxin B | Pseudomonas aeruginosa | polymyxin b | Reslit | Candidate | |
| - | - | - | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| I175F | - | E. coli | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| Y98N | - | Pseudomonas aeruginosa | colistin | Reslit | Candidate | |
| T159M | - | E. coli | colistin | Reslit | Candidate | |
| L208F | - | Acinetobacter baumannii | colistin | Reslit | Candidate | |
| M4I | - | E. coli | colistin | Reslit | Candidate | |
| E464D | - | E. coli | colistin | Reslit | Candidate | |
| D47N | mutations in pmrB contribute to colistin resistance | Pseudomonas aeruginosa | colistin | Reslit | Candidate | |
| - | - | Acinetobacter baumannii | polymyxin b | Reslit | Candidate | |
| - | - | Escherichia coli | colistin | Reslit | Candidate | |
| - | - | Escherichia coli | polymyxins | Reslit | Candidate | |
| V31F | - | Acinetobacter baumannii | colistin | Reslit | Candidate | |
| V46E | - | - | colistin | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | colistin | Reslit | Candidate | |
| V88A | - | E. coli | colistin | Reslit | Candidate | |
| V91E | - | E. coli | colistin | Reslit | Candidate | |
| - | loss of function | Escherichia coli, E. coli | colistin | Reslit | Candidate | |
| L105Q | - | E. coli | colistin | Reslit | Candidate | |
| V128E | - | E. coli | colistin | Reslit | Candidate |
Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system.
pmrB
Phosphoethanolamine Modification of Lipid A in Colistin-Resistant Variants of Acinetobacter baumannii Mediated by the pmrAB Two-Component Regulatory System.
Mutations in pmrB were found in colistin-resistant isolates.
The pmrCAB Operon Mediates Polymyxin Resistance in Acinetobacter baumannii ATCC 17978 and Clinical Isolates through Phosphoethanolamine Modification of Lipid A.
Mutations in the pmrB gene contribute to polymyxin resistance in A. baumannii.
pmrB
PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.
Multiple pmrB mutations were identified in clinical isolates, including single and double missense mutations in the periplasmic and DHP domains.
pmrB
Differential Role of Two-Component Regulatory Systems (phoPQ and pmrAB) in Polymyxin B Susceptibility of Pseudomonas aeruginosa.
Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin.
Mutations promoted from gene entry 'pmrB' (model emitted mutations_found inside genes).
pmrB
Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria.
Mutations in pmrB lead to constitutive activation of the pmrA/pmrB system, resulting in increased resistance to polymyxins.
pmrB
Rapid and Consistent Evolution of Colistin Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa during Morbidostat Culture.
Observed in PA77 cultures
pmrB
Molecular Epidemiology and Colistin Resistant Mechanism of mcr-Positive and mcr-Negative Clinical Isolated Escherichia coli.
found in high-MIC isolates
The Versatile Mutational Resistome of Pseudomonas aeruginosa.
Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x
pmrB
Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.
Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development in Escherichia coli by Affecting pmrAB System.
Previously unknown mutation in pmrB
pmrB
Molecular and genome characterization of colistin-resistant Escherichia coli isolates from wild sea lions (Zalophus californianus).
Mutations in pmrB and phoQ were identified but not confirmed to contribute to colistin resistance.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
Genomic Characteristics of Colistin-Resistant Salmonella enterica subsp. enterica Serovar Infantis from Poultry Farms in the Republic of Serbia.
pmrB
Novel Molecular Markers Linked to Pseudomonas aeruginosa Epidemic High-Risk Clones.
associated with high-risk clones
Genomic surveillance, characterization and intervention of a polymicrobial multidrug-resistant outbreak in critical care.
Mutations in pmrB conferred resistance to colistin.
Genomic Insights into a Colistin-Resistant Uropathogenic Escherichia coli Strain of O23:H4-ST641 Lineage Harboring mcr-1.1 on a Conjugative IncHI2 Plasmid from Egypt.
Characterization of Antimicrobial Resistance Mechanisms in Clinical Isolates of Pseudomonas aeruginosa from a Cystic Fibrosis Patient
Risk factors for acquisition of colistin-resistant Klebsiella pneumoniae and expansion of a colistin-resistant ST307 epidemic clone in hospitals in Marseille, France, 2014 to 2017.
Predicted to modify protein function by PROVEAN analysis.
A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii.
Antimicrobial Resistance Mechanisms and Virulence of Colistin- and Carbapenem-Resistant Acinetobacter baumannii Isolated from a Teaching Hospital in Taiwan.
Mutations in pmrB are associated with colistin resistance.
A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility.
Mutations in PmrA/PmrB lead to constitutive activation of the arnBCADTEF operon and pmrC.
Epidemiological and genomic characteristics of Acinetobacter baumannii from different infection sites using comparative genomics.
Mutations in pmrB were associated with polymyxin resistance.
Genotyping of paired KPC-producing Klebsiella pneumoniae isolates with and without divergent polymyxin B susceptibility profiles.
Substitutions in PmrB were associated with polymyxin B resistance.
Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis.
The Ser253Leu substitution in PmrB was shown to contribute to colistin resistance through increased pmrCAB operon expression.
Genomic Characterization of Extensively Drug-Resistant NDM-Producing Acinetobacter baumannii Clinical Isolates With the Emergence of Novel bla (ADC-257).
Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China.
D313N mutation in pmrB increased colistin MIC by 16-fold.
pmrB
Molecular Epidemiology and Colistin-Resistant Mechanism of mcr-Positive and mcr-Negative Escherichia coli Isolated From Animal in Sichuan Province, China.
Mutations in PmrB were found in mcr-negative colistin-resistant E. coli isolates.
Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa.
A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital.
Three missense mutations identified, T157P validated to increase colistin MIC
Prevalence and molecular characteristics of colistin-resistant isolates among carbapenem-resistant Klebsiella pneumoniae in Central South China: a multicenter study.
Tracking clonal and plasmid transmission in colistin- and carbapenem-resistant Klebsiella pneumoniae.
mutation in pmrB gene confers colistin resistance
No Emergence of Colistin Resistance in the Respiratory Tract of Lung Transplant Patients Treated With Inhaled Colistin.
Mutation found in P. aeruginosa
From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings.
Molecular characterization of colistin resistance in carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital in China.
Transmission of extended spectrum β-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.
Resistance, heteroresistance, and fitness costs drive colistin treatment failure during Acinetobacter baumannii pneumonia.
Both mutations are in the PmrB histidine kinase domain and contribute to colistin resistance.
Genetic analysis of colistin resistance in Salmonella enterica serovar Typhimurium.
Transcriptome Remodeling of Acinetobacter baumannii during Infection and Treatment.
Transcriptional and Mutational Profiling of an Aminoglycoside-Resistant Pseudomonas aeruginosa Small-Colony Variant.
A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition.
Whole-genome analyses of extended-spectrum or AmpC β-lactamase-producing Escherichia coli isolates from companion dogs in Japan.
associated with polymyxin resistance
Colistin Resistance Among Multiple Sequence Types of Klebsiella pneumoniae Is Associated With Diverse Resistance Mechanisms: A Report From India.
Molecular Analysis of Polymyxin Resistance among Carbapenemase-Producing Klebsiella pneumoniae in Colombia.
Mutations in pmrB
Antimicrobial Resistance Profile and ExPEC Virulence Potential in Commensal Escherichia coli of Multiple Sources.
Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin.
Antimicrobial Resistance Determinants in Genomes and Plasmids from Acinetobacter baumannii Clinical Isolates.
Acquisition of the mcr-1 Gene Lowers the Target Mutation to Impede the Evolution of a High-Level Colistin-Resistant Mutant in Escherichia coli.
Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolates Carrying bla (VIM-2) and bla (KPC-2) Genes That Spread on Different Genetic Environment in Colombia.
Colistin and Carbapenem-Resistant Acinetobacter baumannii Aci46 in Thailand: Genome Analysis and Antibiotic Resistance Profiling.
novel mutations
Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence.
mutation in pmrB leads to colistin resistance
Molecular Mechanisms of Colistin Resistance in Klebsiella pneumoniae in a Tertiary Care Teaching Hospital.
Plasmid-mediated colistin resistance and ESBL production in Escherichia coli from clinically healthy and sick pigs.
Carbapenem-Resistant Acinetobacter baumannii in U.S. Hospitals: Diversification of Circulating Lineages and Antimicrobial Resistance.
Prevalence and genetic characterization of clinically relevant extended-spectrum β-lactamase-producing Enterobacterales in the Gulf Cooperation Council countries.
Phenotypic and genetic heterogeneity of Acinetobacter baumannii in the course of an animal chronic infection.
The PmrB(P170T) mutation was confirmed to confer colistin resistance.
In vitro pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against Acinetobacter baumannii.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
Genomic Characterization of Escherichia coli Isolates from Alpaca Crias (Vicugna pacos) in the Peruvian Highlands: Insights into Functional Diversity and Pathogenicity.
Killing two birds with one stone: emergence of colistin and cefiderocol resistance in a mucoid MDR Acinetobacter baumannii under colistin pressure.
Polymyxin-resistant hypervirulent Klebsiella pneumoniae clinical isolates from a tertiary hospital in China: molecular mechanisms, antimicrobial susceptibility, and virulent phenotypes.
Identified in the study and consistent with previous research.
The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions.
Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health Perspectives.
Rapid resistance evolution entails a growth cost
Stereochemical Trajectories of a Two-Component Regulatory System PmrA/B in a Colistin-Resistant Acinetobacter baumannii Clinical Isolate.
Mutations in the transmembrane domain may lead to loss of domain conformation and promote phosphorylation of PmrB.
Polymyxin Resistance Among XDR ST1 Carbapenem-Resistant Acinetobacter baumannii Clone Expanding in a Teaching Hospital.
mutations in pmrB are associated with polymyxin resistance
Emergence of colistin-resistant Klebsiella pneumoniae isolates in Iran: molecular mechanisms and resistance patterns
associated with colistin resistance
Risk Factors for and Mechanisms of COlistin Resistance Among Enterobacterales: Getting at the CORE of the Issue.
Mutations identified in E. coli isolates
Detection of Colistin Resistance in Pseudomonas aeruginosa Using the MALDIxin Test on the Routine MALDI Biotyper Sirius Mass Spectrometer.
Mutations in pmrB were associated with colistin resistance.
Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis.
Mutations in PmrB contribute to colistin resistance.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
Mutation in pmrB gene associated with colistin resistance
Analysis of colistin resistance in carbapenem-resistant Enterobacterales and XDR Klebsiella pneumoniae.
Characterization of Metallo β-Lactamase Producing Enterobacterales Isolates with Susceptibility to the Aztreonam/Avibactam Combination.
Colistin Resistance Mechanism and Management Strategies of Colistin-Resistant Acinetobacter baumannii Infections.
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics.
E123D mutation not experimentally confirmed to increase MIC, but observed in colistin-resistant clinical isolates.
Insight into the PmrB structures of colistin-resistant Gram-negative bacteria through the multi-template ligand-guided homology modeling and in silico mutagenesis.
Mutations in the PmrB histidine kinase affect ATP binding and contribute to colistin resistance
Mutations in PmrB affect ATP binding affinity and protein stability, influencing colistin resistance.
Clonal transmission and species-specific mechanisms of polymyxin resistance in carbapenem-resistant Enterobacteriaceae from Southwest China.
Mutations in pmrB contribute to polymyxin resistance.
Detection of Genes Associated with Polymyxin and Antimicrobial Peptide Resistance in Isolates of Pseudomonas aeruginosa.
In Vivo Selection of Pan-Drug Resistant Acinetobacter baumannii during Antibiotic Treatment.
novel mutation
In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem.
Genomic islands 1 and 2 play key roles in the evolution of extensively drug-resistant ST235 isolates of Pseudomonas aeruginosa.
Mutation in pmrB contributes to colistin resistance
Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.
The pmrB gene was found to harbor a mutation in stable polymyxin-resistant samples, which conferred resistance to polymyxin B and colistin.
The Essential Role of Hypermutation in Rapid Adaptation to Antibiotic Stress.
Mutations in pmrB contribute to colistin resistance.
Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa.
Dissecting Colistin Resistance Mechanisms in Extensively Drug-Resistant Acinetobacter baumannii Clinical Isolates.
Mutations in pmrB lead to overexpression of pmrC, contributing to colistin resistance.
In vitro reduction of colistin susceptibility and comparative genomics reveals multiple differences between MCR-positive and MCR-negative colistin-resistant Escherichia coli.
Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa.
mutations in pmrB lead to cross-resistance to aminoglycosides and colistin
Occurrence and Characterization of mcr-1-Positive Escherichia coli Isolated From Food-Producing Animals in Poland, 2011-2016.
mutation in the chromosomal pmrB gene
Evolutionary stability of collateral sensitivity in Pseudomonas aeruginosa
Characterization Of Chromosome-Mediated Colistin Resistance In Escherichia coli Isolates From Livestock In Korea.
observed in 13 isolates
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
Pathogenomics and Evolutionary Epidemiology of Multi-Drug Resistant Clinical Klebsiella pneumoniae Isolated from Pretoria, South Africa.
Genomic Characterization of Antibiotic Resistant Escherichia coli Isolated From Domestic Chickens in Pakistan.
Challenges in the Detection of Polymyxin Resistance: From Today to the Future.
Clinical and Microbiological Risk Factors for 30-Day Mortality of Bloodstream Infections Caused by OXA-48-Producing Klebsiella pneumoniae.
Polymyxin Resistance in Salmonella: Exploring Mutations and Genetic Determinants of Non-Human Isolates.
In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients.
Resistome Analysis of Klebsiella pneumoniae Complex from Residential Aged Care Facilities Demonstrates Intra-facility Clonal Spread of Multidrug-Resistant Isolates.
Prevalence and molecular characterization of colistin resistance in Pseudomonas aeruginosa isolates: insights from a study in Ardabil hospitals.
In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment.
The PmrB L82R mutation was identified in the colistin-resistant isolate KPB-2.
Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii.
mutated in pmrB gene
Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae.
Multiple point mutations in pmrB were associated with colistin resistance in A. baumannii and K. pneumoniae.
The Occurence of Colistin-Resistant Hypervirulent Klebsiella pneumoniae in China.
Cloning of pmrB encoding the P344L substitution into a colistin-susceptible K. pneumoniae strain did not alter MICs of colistin, suggesting that such a substitution did not confer resistance to colistin.
Rapid detection of colistin resistance in Acinetobacter baumannii using MALDI-TOF-based lipidomics on intact bacteria.
Characterization of a carbapenem- and colistin-resistant Enterobacter cloacae carrying Tn6901 in bla (NDM-1) genomic context.
Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates.
Mutations in pmrB are associated with colistin resistance and QAC resistance
Quaternary ammonium compounds of emerging concern: Classification, occurrence, fate, toxicity and antimicrobial resistance.
Mutations in pmrB were associated with increased resistance to polymyxin, tetracycline, and ciprofloxacin.
Prevalence of Mutated Colistin-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis.
Mutations in pmrB, particularly Thr157Pro, are frequently reported in colistin-resistant K. pneumoniae isolates and are associated with increased resistance.
Emergence of Colistin-Resistant Acinetobacter junii in China.
Prevalence and whole genome phylogenetic analysis reveal genetic relatedness between antibiotic resistance Salmonella in hatchlings and older chickens from farms in Nigeria.
associated with colistin resistance
Comparative genomics and molecular epidemiology of colistin-resistant Acinetobacter baumannii.
Mutations in pmrB were associated with colistin resistance.
Whole-genome sequence analysis of clinically isolated carbapenem resistant Escherichia coli from Iran.
Quinolone-resistant Escherichia coli at the interface between humans, poultry and their shared environment- a potential public health risk.
Single substitution
Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring bla(NDM-1) and bla(KPC-2) in a tertiary hospital in China.
Molecular typing methods & resistance mechanisms of MDR Klebsiella pneumoniae.
CORE" a new assay for rapid identification of Klebsiella pneumoniae COlistin REsistant strains by MALDI-TOF MS in positive-ion mode.
pmrB (P95L) and pmrB (G256R) are associated with colistin resistance in K. pneumoniae.
Identification of mcr-1 Genes and Characterization of Resistance Mechanisms to Colistin in Escherichia coli Isolates from Colombian Hospitals.
Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology.
Mutations in pmrB lead to constitutive activation of PmrA, increasing expression of pmrCAB and conferring colistin resistance.
In vivo adaptive antimicrobial resistance in Klebsiella pneumoniae during antibiotic therapy.
MvfR Controls Tolerance to Polymyxin B by Regulating rfaD in Pseudomonas aeruginosa.
Mutations in pmrB contribute to polymyxin B resistance in P. aeruginosa.
The clinical features and genomic epidemiology of carbapenem-resistant Acinetobacter baumannii infections at a tertiary hospital in Vietnam.
Inactivation of lipid A biosynthesis genes lpsB, lpxC, lpxD, lpxL, lpxM , and/or lpxA and/or lpxB in A. pittii-ST207 and A. seifertii-STNF.
The molecular characterization of colistin-resistant isolates of Acinetobacter baumannii from patients at intensive care units.
Detection of maternal transmission of resistant Gram-negative bacteria in a Cambodian hospital setting.
Not considered as colistin resistant as per previous studies
Escherichia coli B-Strains Are Intrinsically Resistant to Colistin and Not Suitable for Characterization and Identification of mcr Genes.
Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii.
Mutations in pmrB were mentioned in the context of a reference strain.
Multiple heteroresistance to tigecycline and colistin in Acinetobacter baumannii isolates and its implications for combined antibiotic treatment.
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
Acinetobacter baumannii Global Clone-Specific Resistomes Explored in Clinical Isolates Recovered from Egypt.
Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
mutations in pmrB lead to colistin resistance
Molecular mechanisms of colistin- and multidrug-resistance in bacteria among patients with hospital-acquired infections.
mutations in pmrB gene contribute to colistin resistance
Chromosome-Mediated Colistin Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli: Mutation Analysis in the Light of Genetic Background.
Present in KPN-7
The PitA protein contributes to colistin susceptibility in Pseudomonas aeruginosa.
The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research.
Mutations in pmrB lead to resistance to colistin.
Experimental evolution of Pseudomonas aeruginosa to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environments.
Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin.
Mutations in pmrB were associated with colistin resistance.
Comparative genotypic characterization related to antibiotic resistance phenotypes of clinical carbapenem-resistant Acinetobacter baumannii MTC1106 (ST2) and MTC0619 (ST25).
Mutations in pmrB gene of MTC1106
Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant Acinetobacter baumannii clinical isolates.
Detected in colistin-resistant isolates.
Rapid determination of colistin resistance in clinical strains of Acinetobacter baumannii by use of the micromax assay.
Mutation in pmrB leads to colistin resistance.
Genome analysis of a transmissible lineage of pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators.
The induction and identification of novel Colistin resistance mutations in Acinetobacter baumannii and their implications.
Mutations in pmrB were observed in ATCC19606, BAL062, and BAL242.
Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii.
Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae.
missense mutation
Growth Rate and Biofilm Formation Ability of Clinical and Laboratory-Evolved Colistin-Resistant Strains of Acinetobacter baumannii.
Mutation in pmrB gene leads to colistin resistance.
Resistome of carbapenem- and colistin-resistant Klebsiella pneumoniae clinical isolates.
point mutations in pmrB
New Mutations Involved in Colistin Resistance in Acinetobacter baumannii.
Abundance of Colistin-Resistant, OXA-23- and ArmA-Producing Acinetobacter baumannii Belonging to International Clone 2 in Greece.
Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae.
Mutations in PmrAB that constitutively activate arn operon transcription were found to cause colistin resistance.
Emerging high-risk ST101 and ST307 carbapenem-resistant Klebsiella pneumoniae clones from bloodstream infections in Southern Italy.
Two ST101 isolates (164BR and 177BR) had this mutation.
A Diverse Panel of Clinical Acinetobacter baumannii for Research and Development.
Mutation in pmrB leads to colistin resistance
Colistin Heteroresistance among Extended Spectrum β-lactamases-Producing Klebsiella pneumoniae.
Overcoming addition of phosphoethanolamine to lipid A mediated colistin resistance in Acinetobacter baumannii clinical isolates with colistin-sulbactam combination therapy.
Constitutive Phenotypic Modification of Lipid A in Clinical Acinetobacter baumannii Isolates.
Mutations in pmrB were observed only in PMB R strains.
High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy.
mutations in pmrB contribute to colistin resistance
Polymyxin Resistance in Clinical Isolates of K. pneumoniae in Brazil: Update on Molecular Mechanisms, Clonal Dissemination and Relationship With KPC-Producing Strains.
mutations in PmrB contribute to polymyxin resistance
Genetic Diversity of Virulent Polymyxin-Resistant Klebsiella aerogenes Isolated from Intensive Care Units.
Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Romanian Hospitals Co-Presenting Resistance and Heteroresistance to Colistin.
Mutations in pmrB were observed in multiple strains and are associated with colistin resistance
Preferential Selection of Low-Frequency, Lipopolysaccharide-Modified, Colistin-Resistant Mutants with a Combination of Antimicrobials in Acinetobacter baumannii.
Mutations promoted from gene entry 'pmrB' (model emitted mutations_found inside genes).
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.
missense mutation
Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp.
Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand.
High prevalence of polymyxin-heteroresistant carbapenem-resistant Klebsiella pneumoniae and its within-host evolution to resistance among critically ill scenarios.
Mutations in pmrB contribute to polymyxin resistance
Polymyxin resistance in Enterobacter cloacae complex in Brazil: phenotypic and molecular characterization.
Polymorphism of genes encoding PmrAB in colistin-resistant strains of Escherichia coli and Salmonella enterica isolated from poultry and swine.
pmrB
Comparison of the antinociceptive and motor effects of intrathecal opioid agonists in the rat.
Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections.
pmrB
Correlation between overexpression and amino acid substitution of the PmrAB locus and colistin resistance in Acinetobacter baumannii.
pmrB
Identification of pmrB mutations as putative mechanism for colistin resistance in A. baumannii strains isolated after in vivo colistin exposure.
pmrB
Growth retardation, reduced invasiveness, and impaired colistin-mediated cell death associated with colistin resistance development in Acinetobacter baumannii.
pmrB
Sanford C. Barnum, discoverer of the rubber dam.
pmrB
In vivo emergence of colistin resistance in Acinetobacter baumannii clinical isolates of sequence type 357 during colistin treatment.
pmrB
[Ribosomal RNA sequencing with reverse transcriptase: its application to the phylogenetic study of cells].
pmrB
Health at work.
pmrB
Effect of wheat fiber and vitamins C and E supplements on rectal polyps in patients at high risk for colon cancer.
pmrB
Microevolution of acquired colistin resistance in Enterobacteriaceae from ICU patients receiving selective decontamination of the digestive tract.
pmrB
Colistin resistance in Parisian inpatient faecal Escherichia coli as the result of two distinct evolutionary pathways.
pmrB
Mutant prevention concentrations of colistin for Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae clinical isolates.
pmrB
Rapid Detection of Polymyxin Resistance in Enterobacteriaceae.
pmrB
MgrB inactivation is a common mechanism of colistin resistance in KPC-producing Klebsiella pneumoniae of clinical origin.
pmrB
Worldwide emergence of colistin resistance in Klebsiella pneumoniae from healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB: an epidemiological and molecular study.
pmrB
Reduced Fitness Costs of mcr-1.2 Compared to Mutated pmrB in Isogenic Colistin-Resistant KPC-3-Producing Klebsiella pneumoniae.
pmrB
Transport proteins. Export-import family expands.
pmrB
Mutations and expression of PmrAB and PhoPQ related with colistin resistance in Pseudomonas aeruginosa clinical isolates.
pmrB
Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2).
pmrB
Are there "innocent" amniotic bands?
pmrB
A single amino acid substitution in PmrB is associated with polymyxin B resistance in clinical isolate of Pseudomonas aeruginosa.
pmrB
Acquisition of extended-spectrum cephalosporin- and colistin-resistant Salmonella enterica subsp. enterica serotype Newport by pilgrims during Hajj.
pmrB
Molecular characteristics of chromosome-mediated colistin resistance in foodborne Salmonella isolates in China.
pmrB
Emerging carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Lima, Peru.
Colistin Resistance and Extensive Genetic Variations in PmrAB and PhoPQ in Klebsiella Pneumoniae Isolates from South Korea.
A prospective matched case-control study on the genomic epidemiology of colistin-resistant Enterobacterales from Dutch patients.
Mutations in pmrB were primarily found in colistin-resistant E. coli isolates.
A Retrospective Whole-Genome Sequencing Analysis of Carbapenem and Colistin-Resistant Klebsiella Pneumoniae Nosocomial Strains Isolated during an MDR Surveillance Program.
In vitro potentiation of tetracyclines in Pseudomonas aeruginosa by RW01, a new cyclic peptide.
Mutations in pmrB were associated with resistance to colistin and cross-resistance to other antibiotics.
Colistin Resistance Onset Strategies and Genomic Mosaicism in Clinical Acinetobacter baumannii Lineages.
Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France.
New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides.
Mutation in pmrB contributes to colistin resistance
Critical Role of 3'-Downstream Region of pmrB in Polymyxin Resistance in Escherichia coli BL21(DE3).
The G361A mutation in pmrB is critical for colistin resistance.
Antibiotic resistance among Escherichia coli and Salmonella isolated from dairy cattle feces in Texas.
confers resistance to polymyxins
Evaluating the accuracy of the MBT Lipid Xtract Kit for assessing colistin resistance in comparison to broth microdilution.
An allelic variant of the PmrB sensor kinase responsible for colistin resistance in an Escherichia coli strain of clinical origin.
The pmrB gene was found to carry a novel mutation in the clinical isolate LC711/14, which was experimentally validated to confer colistin resistance.
Genomic Characterization of Prevalent mcr-1, mcr-4, and mcr-5 Escherichia coli Within Swine Enteric Colibacillosis in Spain.