ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeT140P

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: two-component system sensor histidine kinase PmrB
Resistance To: colistin
Organisms: Klebsiella pneumoniae
Papers: 2

Paper Information2

In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients.

PMID 38411998 · 2024

Mutation Information

pmrB: p.T140P

Protein Change: T140P
Organisms: Klebsiella pneumoniae
Confers Resistance To: colistin
Validation Method: whole-genome sequencing
Source Database: Reslit

Worldwide emergence of colistin resistance in Klebsiella pneumoniae from healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB: an epidemiological and molecular study.

PMID 25264127 · 2014

pmrB

Mutation Information

pmrB: p.T140P

Protein Change: T140P
Organisms: Klebsiella pneumoniae
Confers Resistance To: colistin
Effect on Function: two-component system sensor histidine kinase PmrB
Source Database: Reference Gene Catalog

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