ResLit - Antimicrobial Resistance Gene & Mutation Database

GenepmrB

Protein ChangeT232I

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: two-component system sensor histidine kinase PmrB
Resistance To: polymyxin b, colistin
Organisms: Acinetobacter baumannii
Papers: 2

Paper Information2

Polymyxin Resistance Among XDR ST1 Carbapenem-Resistant Acinetobacter baumannii Clone Expanding in a Teaching Hospital.

PMID 33897637 · 2021

mutations in pmrB are associated with polymyxin resistance

Mutation Information

pmrB: p.T232I

Protein Change: T232I
Organisms: Acinetobacter baumannii
Confers Resistance To: polymyxin b
Validation Method: genome sequencing
Source Database: Reslit

Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections.

PMID 23812239 · 2013

pmrB

Mutation Information

pmrB: p.T232I

Protein Change: T232I
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Effect on Function: two-component system sensor histidine kinase PmrB
Source Database: Reference Gene Catalog

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