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Browse Mutations gyrBL422P

GenegyrB

Protein ChangeL422P

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: ciprofloxacin
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Repeated Exposure of Escherichia coli to High Ciprofloxacin Concentrations Selects gyrB Mutants That Show Fluoroquinolone-Specific Hyperpersistence.

PMID 35707170 · 2022

The mutation is outside the canonical GyrB QRDR.

Mutation Information

Protein Change: L422P
Organisms: Escherichia coli
Confers Resistance To: ciprofloxacin
Validation Method: whole-genome sequencing and time-kill assays
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research