ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeL58P

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disrupt the binding affinity of RamR to the ramA promoter
Resistance To: eravacycline|tetracycline|tigecycline|minocycline|levofloxacin|ceftazidime|cefepime|cefoxitin|imipenem|meropenem|piperacillin tazobactam|ceftolozane tazobactam|aztreonam|colistin|ertapenem|ampicillin sulbactam|imipenem relebactam
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae.

mutations in ramR lead to upregulation of efflux pumps

Protein Change: L58P
Organisms: Klebsiella pneumoniae
Confers Resistance To: eravacycline|tetracycline|tigecycline|minocycline|levofloxacin|ceftazidime|cefepime|cefoxitin|imipenem|meropenem|piperacillin tazobactam|ceftolozane tazobactam|aztreonam|colistin|ertapenem|ampicillin sulbactam|imipenem relebactam
Effect on Function: disrupt the binding affinity of RamR to the ramA promoter
Validation Method: genetic sequencing and phenotypic and functional assays
Source Database: Reslit

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