ResLit - Antimicrobial Resistance Gene & Mutation Database

GenegyrA

Protein ChangeE88A

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: single resistance variant, DNA gyrase subunit A GyrA
Resistance To: ciprofloxacin|enrofloxacin, fluoroquinolones, quinolones
Organisms: Staphylococcus coagulans, Staphylococcus aureus
Papers: 2

Paper Information2

Phenotypic and Molecular Traits of Staphylococcus coagulans Associated with Canine Skin Infections in Portugal.

PMID 34063179 · 2021

Mutation Information

gyrA: p.E88A

Protein Change: E88A
Organisms: Staphylococcus coagulans
Confers Resistance To: ciprofloxacin|enrofloxacin
Validation Method: sequencing
Source Database: Reslit

Topoisomerase mutations that are associated with high-level resistance to earlier fluoroquinolones in Staphylococcus aureus have less effect on the antibacterial activity of besifloxacin.

PMID 21996946 · 2011

Staphylococcus aureus gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003296

gyrA

Mutation Information

gyrA: p.E88A

Protein Change: E88A
Organisms: Staphylococcus aureus
Confers Resistance To: fluoroquinolonesquinolones
Effect on Function: single resistance variant; DNA gyrase subunit A GyrA
Source Database: Card DatabaseReference Gene Catalog

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