ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeF183L

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: isoniazid
Organisms: Mycobacterium tuberculosis
Papers: 2

Paper Information2

Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China.

PMID 34466004 · 2021

Mutations in the katG gene are associated with isoniazid resistance.

Mutation Information

katG: p.F183L

Protein Change: F183L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: isoniazid
Validation Method: whole genome sequencing
Source Database: Reslit

Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis.

PMID 36635309 · 2023

All mutations were identified in the katG gene and are associated with isoniazid resistance.

Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392

Mutation Information

katG: p.F183L

Protein Change: F183L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: isoniazid
Effect on Function: single resistance variant
Validation Method: genotypic resistance prediction using TB-Profiler software and phenotypic DST data
Source Database: ReslitCard Database

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