Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
catalase-peroxidase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S315T | confers resistance, results in an enzyme without the ability to activate isoniazid, but retains approximately 50% of its catalase-peroxidase activity, The katG Ser315Thr alteration results in an enzyme that cannot activate INH but that still maintains significant catalase-peroxidase activity, thus permitting the INH-resistant organism to survive in the presence of oxidative stress., mutations in katG, in particular at codon 315 (katG315), are commonly observed to cause resistance to INH, profoundly decrease INH activation and result in drug resistance, resistance to isoniazid, loss of catalase-peroxidase activity, high-level drug resistance, reduced catalytic activity, single resistance variant, multiple resistance variants | Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium simiae, M. bovis, human, M. tuberculosis | isoniazidrifampicinisoniazid|ethambutol+1 more | ReslitCard Database | Candidate | |
| G428R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| D328A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L463R | - | - | Mycobacterium bovis | isoniazid | Reslit | Candidate |
| E506K | - | - | Mycobacterium bovis | isoniazid | Reslit | Candidate |
| R463L | mild to moderate destabilising, single resistance variant | Mycobacterium tuberculosis, Mycobacterium bovis, Arcobacter butzleri | isoniazidstreptomycin|isoniazid|prothionamide | ReslitCard Database | Candidate | |
| S315N | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | ReslitCard Database | Candidate | |
| R418Q | - | loss of catalase-peroxidase activities | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| D117A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| M257I | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G491C | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R104L | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W107R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W107F | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| H108E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| H108Q | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| N138D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| N138S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| Y229F | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T262R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T275P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T275V | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W300G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| S315G | - | loss of catalase-peroxidase activity, single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | ReslitCard Database | Candidate |
| S315I | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| S315R | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate | |
| W328G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W328F | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| Y337C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A350S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| L587M | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| G629S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D735N | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| M255C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| M255I | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| M255Y | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| E217G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| D329A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R315P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S17N | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| G206S | - | - | - | isoniazid | Reslit | Candidate |
| E340Q | - | - | - | isoniazid | Reslit | Candidate |
| W191* | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| T271P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L546P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| D695G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| M102I | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S317N | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G105R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| C15T | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R128G | - | - | - | isoniazid | Reslit | Candidate |
| D142G | - | single resistance variant | Mycobacterium tuberculosis, Mycobacterium smegmatis | isoniazidprothionamide | ReslitCard Database | Candidate |
| W321G | - | - | - | isoniazid | Reslit | Candidate |
| A614E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W90R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A109V | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| S315A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G299S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| I335V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A144V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| H97R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| E607K | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S17G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| W328C | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S105T | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| R315S | - | - | - | isoniazid | Reslit | Candidate |
| S315L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L611R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R315T | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| V284G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P375R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Y413C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D448N | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| W438S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G299R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L238R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| V61G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Q247H | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A62T | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| W91R | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | ReslitCard Database | Candidate |
| M105I | - | - | - | isoniazid | Reslit | Candidate |
| Y98S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| M105K | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| N138H | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A139P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| R145P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| V151F | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| F183L | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D189G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W191G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| G234E | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R249H | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L298S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L382R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| T394A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S481L | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| R498H | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L619R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G630V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R632H | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Y711D | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| W728R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Y597D | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| T568P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A476V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S302R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| W300C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| G297V | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| L159F | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G156D | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L141F | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| Y98C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W191R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| S315X | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S135T | - | - | - | isoniazid | Reslit | Candidate |
| T315S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A379V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A379T | single resistance variant | Mycobacterium tuberculosis, Arcobacter butzleri | isoniazid | ReslitCard Database | Candidate | |
| R128Q | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A291P | - | - | - | isoniazid | Reslit | Candidate |
| G316S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L653L | - | - | - | isoniazid | Reslit | Candidate |
| A65T | - | - | - | isoniazid | Reslit | Candidate |
| A245V | - | - | - | isoniazid | Reslit | Candidate |
| Q295P | - | - | - | isoniazid | Reslit | Candidate |
| V725A | - | - | - | isoniazid | Reslit | Candidate |
| A315V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A315L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A315C | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A315D | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A315S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| W341C | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R315L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Q525P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| V473N | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D311N | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| L427I | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| L430P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G421D | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P57S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| W438* | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A411D | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| 1561del | - | - | - | isoniazid | Reslit | Candidate |
| S463P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| F185L | - | - | - | isoniazid | Reslit | Candidate |
| V68A | - | - | - | isoniazid | Reslit | Candidate |
| R563L | - | - | - | isoniazid | Reslit | Candidate |
| G548A | - | - | - | isoniazid | Reslit | Candidate |
| R643L | - | - | - | isoniazid | Reslit | Candidate |
| S315F | - | - | - | isoniazid | Reslit | Candidate |
| R463H | - | - | - | isoniazid | Reslit | Candidate |
| L506F | - | - | - | isoniazid | Reslit | Candidate |
| K315R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S293G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A10P | - | - | - | streptomycin | Reslit | Candidate |
| V77G | - | - | - | streptomycin | Reslit | Candidate |
| S94A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| 2424del | - | - | - | isoniazid | Reslit | Candidate |
| I317V | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| P241A | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P377S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Y597H | - | multiple resistance variants | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| P131T | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A162V | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| G269D | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T306P | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D387G | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T394M | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A541D | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| Y95C | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D194G | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| N596S | - | multiple resistance variants | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| Q439P | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| F483L | - | single resistance variant | Mycobacterium smegmatis, Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| G309V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L141S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A172G | - | - | - | isoniazid | Reslit | Candidate |
| H445Y | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| V230L | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| P232S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D142A | - | - | - | isoniazid | Reslit | Candidate |
| A479E | - | - | isoniazid | Reslit | Candidate | |
| P232L | - | reduced INH-KatG binding affinity | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Q461* | - | truncated gene transcription | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| 4del | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| T354I | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G421S | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| V721M | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| R35Q | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G273R | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| Y315H | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| G609R | - | - | - | isoniazid | Reslit | Candidate |
| G87V | - | - | - | isoniazid | Reslit | Candidate |
| D137S | - | - | - | isoniazid | Reslit | Candidate |
| A109T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| Q439H | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate | |
| G169S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T677P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D419Y | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| R484H | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| N655D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W161C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A312E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| R78P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D189N | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D675Y | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| E233G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| G124S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A122D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| R385P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| Q88P | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate | |
| G182R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| L132R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| M257V | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T271I | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| T326P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| D419H | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| W328L | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| L48P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| T275A | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | ReslitCard Database | Candidate |
| W321C | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| T322A | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| R385W | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A110V | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | ReslitCard Database | Candidate |
| L499M | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| L587P | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| S513T | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| V1A | - | - | - | isoniazid | Reslit | Candidate |
| W438R | - | - | - | isoniazid | Reslit | Candidate |
| D406A | - | - | - | isoniazid | Reslit | Candidate |
| D296E | - | - | - | isoniazid | Reslit | Candidate |
| A61T | - | - | - | isoniazid | Reslit | Candidate |
| V68G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| A122V | - | - | - | isoniazid | Reslit | Candidate |
| F129L | - | - | - | isoniazid | Reslit | Candidate |
| L148R | - | - | - | isoniazid | Reslit | Candidate |
| T180K | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| E195K | - | - | - | isoniazid | Reslit | Candidate |
| Q224E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | ReslitCard Database | Candidate |
| V230A | - | - | - | isoniazid | Reslit | Candidate |
| G234R | - | - | - | isoniazid | Reslit | Candidate |
| T275S | - | - | - | isoniazid | Reslit | Candidate |
| G299A | - | - | - | isoniazid | Reslit | Candidate |
| P280H | - | - | - | isoniazid | Reslit | Candidate |
| Y304S | - | - | - | isoniazid | Reslit | Candidate |
| G307E | - | - | - | isoniazid | Reslit | Candidate |
| G309C | - | - | - | isoniazid | Reslit | Candidate |
| E318K | - | - | - | isoniazid | Reslit | Candidate |
| N238K | - | - | - | isoniazid | Reslit | Candidate |
| L587I | - | - | - | isoniazid | Reslit | Candidate |
| L619P | - | - | - | isoniazid | Reslit | Candidate |
| L634F | - | - | - | isoniazid | Reslit | Candidate |
| A141V | - | - | Acinetobacter baumannii | colistin | Reslit | Candidate |
| D105G | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| A424V | - | - | - | isoniazid | Reslit | Candidate |
| T380I | - | - | - | isoniazid | Reslit | Candidate |
| E588Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| P131R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L101P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| P131Q | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| M126I | - | single resistance variant, multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| D194Y | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| E454Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| D63E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W321F | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| R418L | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Q127E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| N133T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S383P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| R489S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| M420T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| D387H | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G123E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| M176T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| R632C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| D542H | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Y64S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G32D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V47E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| A256T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| T667P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| M624V | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| I335T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| E506Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Q127P | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| Q352E | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G269R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S17T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| A93T | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| A139V | single resistance variant | Mycobacterium tuberculosis, Arcobacter butzleri | isoniazid | Card DatabaseReslit | Candidate | |
| H276M | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Q295H | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G19D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| A243S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| A550D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| P2S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S140N | single resistance variant | Mycobacterium tuberculosis, Arcobacter butzleri | isoniazid | Card DatabaseReslit | Candidate | |
| G279D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G285D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G316D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S457I | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G593D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S303L | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S303C | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Y304Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| D311S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L430V | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| T435R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L436G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Q471Y | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Q471H | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L472K | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L472Q | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L472I | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473I | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473K | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473M | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473F | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473W | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473Y | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V473G | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| A312P | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| N660D | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| L147P | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| N508D | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| G125S | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| Q461P | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| E607A | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| H417Q | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| G111S | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| G33V | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| W91Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| R496L | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| C20R | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| S211G | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| V581G | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| G466R | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| G279V | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| L436P | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| P92S | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| V431A | - | multiple resistance variants | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| G490S | - | multiple resistance variants, single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Candidate |
| P365R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| G125D | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L159P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| L704S | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| P232R | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| R104Q | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S700P | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V633A | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W505Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S315Var | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| V1Var | - | single resistance variant | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W728Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W689Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S671Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W668Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| E607Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W477Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W438Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Y413Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W412Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W397Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Q352Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W351Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W321Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W300Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W204Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W198Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S175Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| C171Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W161Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Y155Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W149Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Y113Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W107Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W90Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Q88Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| W39Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| Y28Ter | - | nonsense mutation | Mycobacterium tuberculosis | isoniazid | Card Database | Candidate |
| S134S | - | multiple resistance variants | Mycobacterium tuberculosis | prothionamide | Card Database | Candidate |
| T308P | - | multiple resistance variants | Mycobacterium tuberculosis | prothionamide | Card Database | Candidate |
| A264V | - | single resistance variant | Mycobacterium tuberculosis | prothionamide | Card Database | Candidate |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| L378R | - | - | isoniazid | Reslit | Candidate | |
| M172V | - | - | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| R303C | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| L343* | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| A532V | - | - | isoniazid | Reslit | Candidate | |
| T572M | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| A162E | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| A315P | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| V332L | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| T625A | - | - | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate | |
| - | - | - | isoniazid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate | |
| - | - | Mycobacterium tuberculosis | isoniazid | ResFinder Database | Candidate |
Evaluation of the invader assay, a linear signal amplification method, for identification of mutations associated with resistance to rifampin and isoniazid in Mycobacterium tuberculosis.
Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India.
Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.
Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.
Rapid direct detection of multiple rifampin and isoniazid resistance mutations in Mycobacterium tuberculosis in respiratory samples by real-time PCR.
Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.
The Arg418->Gln mutation in KatG leads to loss of catalase-peroxidase activities and confers isoniazid resistance.
Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates collected in Australia.
Three novel katG mutations (D117A, M257I, G491C) were identified in three INH-resistant strains with a wild-type katG codon 315, fabG1-inhA regulatory region, and inhA structural gene.
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.
Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
Mutations in KatG are associated with isoniazid resistance through reduced INH-NADH adduct formation.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Rapid screening of MDR-TB using molecular Line Probe Assay is feasible in Uganda.
Validation of the GenoType MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam.
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
This study
Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis by Use of Real-Time PCR and High-Resolution Melt Analysis.
Genetic variation of Mycobacterium tuberculosis circulating in Kharkiv Oblast, Ukraine.
Mycobacterium tuberculosis spoligotypes and drug susceptibility pattern of isolates from tuberculosis patients in South-Western Uganda.
One strain had this mutation.
Dynamics of antibiotic resistant Mycobacterium tuberculosis during long-term infection and antibiotic treatment.
The AGC315ACC mutation in katG is responsible for isoniazid resistance.
Clonal population of Mycobacterium tuberculosis strains reside within multiple lung cavities.
Comprehensive multicenter evaluation of a new line probe assay kit for identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis.
Mutations in katG were associated with isoniazid resistance.
Molecular characterization of multidrug- and extensively drug-resistant Mycobacterium tuberculosis strains in Jiangxi, China.
Includes several novel mutations
Impact of isoniazid resistance-conferring mutations on the clinical presentation of isoniazid monoresistant tuberculosis.
Drug-resistant tuberculosis transmission and resistance amplification within families.
Dominant incidence of multidrug and extensively drug-resistant specific Mycobacterium tuberculosis clones in Osaka Prefecture, Japan.
First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.
Evaluation of MTBDRplus and MTBDRsl in Detecting Drug-Resistant Tuberculosis in a Chinese Population.
Rapid Detection of Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis Using Real-Time PCR.
Molecular drug susceptibility testing against the first-line (rifampin and isoniazid) and second-line (ciprofloxacin-amikacin and kanamycin) treatment in different subtypes of Mycobacterium simiae.
Antimicrobial Resistance Mechanisms in Mycobacterium tuberculosis: Role of Efflux Pumps and Mutations
Clinical and bacteriological characteristics associated with clustering of multidrug-resistant tuberculosis.
Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages.
Frequency of multi-drug resistance and mutations in Mycobacterium tuberculosis isolates from Punjab state of India.
Known mutation in katG gene for INH resistance
Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad.
Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.
Genetic Identification and Drug-Resistance Characterization of Mycobacterium tuberculosis Using a Portable Sequencing Device. A Pilot Study.
Mutation in katG gene associated with isoniazid resistance.
Evaluation of the frequency of mutation genes in multidrug-resistant tuberculosis (MDR-TB) strains in Beijing, China.
Most frequent mutation
Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China.
Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.
Drug Resistance Conferring Mutation and Genetic Diversity of Mycobacterium tuberculosis Isolates in Tuberculosis Lymphadenitis Patients; Ethiopia.
Phenotypic and genotypic drug sensitivity profiles of Mycobacterium tuberculosis infection and associated factors in northeastern Ethiopia.
Mutation at codon 315 of katG gene leads to isoniazid resistance.
Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2020.
Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany.
Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.
Early detection of MDR Mycobacterium tuberculosis mutations in Pakistan.
Mutations in katG are associated with Isoniazid resistance.
Transmission of multidrug-resistant tuberculosis in Shimen community in Shanghai, China: a molecular epidemiology study.
Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster.
Mutation in katG
The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.
Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
Multiple mutations in katG were associated with isoniazid resistance.
The Regulation of ManLAM-Related Gene Expression in Mycobacterium tuberculosis with Different Drug Resistance Profiles Following Isoniazid Treatment.
Snapshot of Mycobacterium tuberculosis Phylogenetics from an Indian State of Arunachal Pradesh Bordering China.
SAM-TB: a whole genome sequencing data analysis website for detection of Mycobacterium tuberculosis drug resistance and transmission.
Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya.
Detection and characterization of mutations in genes related to isoniazid resistance in Mycobacterium tuberculosis clinical isolates from Iran.
Antimicrobial Resistance in Mycobacterium tuberculosis Clinical Isolates from HIV-Positive and HIV-Negative Patients in Russia
Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors.
Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages.
Mutations in katG are associated with isoniazid resistance in MDR and pre-XDR strains.
Phenotypic drug resistance and genetic mutations linked to resistance among extrapulmonary tuberculosis patients in Ethiopia: Insights from Whole Genome Sequencing.
This mutation is associated with high-level isoniazid resistance.
Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.
Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006-2022.
associated with resistance
Multi-drug resistance and compensatory mutations in Mycobacterium tuberculosis in Vietnam.
In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates.
Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.
Promoter mutations in inhA and ahpC genes
Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China.
Whole-genome sequencing and machine learning reveal key drivers of delayed sputum conversion in rifampicin-resistant tuberculosis.
Unraveling Epistatic Interactions Between Sites Under Drug-Dependent Selection in the Mycobacterium tuberculosis Genome.
Mutation katG:S315T is associated with INH resistance
Molecular insights of drug-resistant tuberculosis: genetic mutations and their profile.
Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: implications for rapid susceptibility testing.
The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis.
most common mutation in isoniazid-resistant strains
Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates from England and Wales reveals the phylogenetic significance of the ahpC −46A polymorphism.
mutant forms of katG 315 are associated with isoniazid resistance
Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns.
Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape Province of South Africa.
Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong.
Detected in multiple isolates
Performance of the genotype MTBDR assay for molecular detection of multidrug-resistant strains of Mycobacterium tuberculosis.
The S531L mutation was most common (21 of 35, 60%) in rpoB, and the S315T mutation was detected in 22 of 35 (63%) MDR-TB strains.
Evaluation of methods for rapid detection of resistance to isoniazid and rifampin in Mycobacterium tuberculosis isolates collected in the Caribbean.
Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints.
Mutation leads to high level resistance.
Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China.
Extensive transmission of isoniazid resistant M. tuberculosis and its association with increased multidrug-resistant TB in two rural counties of eastern China: a molecular epidemiological study.
mutation in katG gene associated with isoniazid resistance
Use of the GenoType(R) MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda.
Mycobacterium tuberculosis cluster with developing drug resistance, New York, New York, USA, 2003-2009.
Improved rapid molecular diagnosis of multidrug-resistant tuberculosis using a new reverse hybridization assay, REBA MTB-MDR.
Rapid diagnosis of extensively drug-resistant tuberculosis by use of a reverse line blot hybridization assay.
Multidrug-resistant tuberculosis drug susceptibility and molecular diagnostic testing.
Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea.
Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.
Rapid and accurate detection of RMP- and INH- resistant Mycobacterium tuberculosis in spinal tuberculosis specimens by CapitalBio™ DNA microarray: a prospective validation study.
Mutation in katG was detected in INH-resistant M. tuberculosis isolates.
Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa.
Rapid Screening of MDR-TB in Cases of Extra Pulmonary Tuberculosis Using Geno Type MTBDRplus.
Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.
most common mutation
Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.
Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.
Genotypic Detection of rpoB and katG Gene Mutations Associated with Rifampicin and Isoniazid Resistance in Mycobacterium Tuberculosis Isolates: A Local Scenario (Kelantan).
Draft genome sequence of Mycobacterium tuberculosis strain B9741 of Beijing B0/W lineage from HIV positive patient from Siberia.
A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt.
Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.
Revisiting the mutant prevention concentration to guide dosing in childhood tuberculosis.
KatG mutations are associated with isoniazid resistance.
Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient.
Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.
Use of DNA microarray chips for the rapid detection of Mycobacterium tuberculosis resistance to rifampicin and isoniazid.
Genotypic Distribution and a Potential Diagnostic Assay of Multidrug-Resistant Tuberculosis in Northern Thailand.
Prevalence and factors associated with multidrug-resistant tuberculosis in South India.
Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis.
Mutations in katG were associated with resistance to pyridine carboxamide prodrugs and isoniazid.
Selected by resistance to 127-17
Xpert MTB/XDR: a 10-Color Reflex Assay Suitable for Point-of-Care Settings To Detect Isoniazid, Fluoroquinolone, and Second-Line-Injectable-Drug Resistance Directly from Mycobacterium tuberculosis-Positive Sputum.
Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand.
Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014-2017.
mutation in katG associated with isoniazid resistance
Evaluation of the Roche cobas MTB and MTB-RIF/INH Assays in Samples from Germany and Sierra Leone.
Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.
Detection of genomic mutations in katG and rpoB genes among multidrug-resistant Mycobacterium tuberculosis isolates from Tehran, Iran.
Significance of the coexistence of non-codon 315 katG, inhA, and oxyR-ahpC intergenic gene mutations among isoniazid-resistant and multidrug-resistant isolates of Mycobacterium tuberculosis: a report of novel mutations.
Novel mutation
Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova.
The katG S315T mutation confers resistance to isoniazid.
Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China.
Mutations in the katG gene are associated with isoniazid resistance.
Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
Performance Evaluation of GeneLEAD/Deeplex Myc-TB for Mycobacterium tuberculosis Complex Diagnosis and Drug Susceptibility Testing
A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing.
Mutations in katG confer resistance to isoniazid
Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.
A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.
Transmission of multidrug-resistant Mycobacterium tuberculosis in Wuhan, China: A retrospective molecular epidemiological study.
Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.
high-confidence mutation
Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.
First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda.
Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
Common mutation underlying MDR-TB for isoniazid.
Drug-resistance characteristics, genetic diversity, and transmission dynamics of multidrug-resistant or rifampicin-resistant Mycobacterium tuberculosis from 2019 to 2021 in Sichuan, China.
Mutation in katG gene associated with isoniazid resistance
Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.
Genotypes and drug resistance pattern of Mycobacterium tuberculosis complex among clinically diagnosed pulmonary tuberculosis patients.
Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts.
Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.
Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon.
Prevalence and Genetic Analysis of Isoniazid-Resistant Tuberculosis in Eastern Uttar Pradesh, India.
Genomic characterization of multidrug-resistant tuberculosis in Shanghai, China: antibiotic resistance, virulence and transmission.
Whole-Genome Sequence-Based Diversity of Mycobacterium tuberculosis Strains Isolated from a Central Western Region of Mexico.
Fitness Effect of the Isoniazid Resistance Mutation S315T of the Catalase-Peroxidase Enzyme KatG of Mycobacterium tuberculosis.
S315T mutation in KatG leads to isoniazid resistance
Delayed culture conversion predicts poor outcomes for isoniazid mono-resistant TB in Uganda: a retrospective cross-sectional study from 2017- 2022.
Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology study.
Off-label evaluation of the BD MAX MDR-TB assay for rapid diagnosis of rifampicin and isoniazid resistance of Mycobacterium tuberculosis clinical isolates in a high-volume reference laboratory.
Mutations in katG confer resistance to isoniazid
Comprehensive analysis of mutations associated with rifampicin- and isoniazid-resistant tuberculosis in a high-burden setting.
associated with resistance
Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).
Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia.
Molecular epidemiology of drug resistance and transmission of Mycobacterium tuberculosis in Meigu County, Sichuan Province, China.
Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).
Mutations in katG are associated with isoniazid resistance.
Use of real-time PCR and fluorimetry for rapid detection of rifampin and isoniazid resistance-associated mutations in Mycobacterium tuberculosis.
New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis.
Mutations in katG gene associated with isoniazid resistance
Phenotypic and molecular characterization of Mycobacterium tuberculosis isolates resistant to both isoniazid and ethambutol.
The paper states that mutations at katG Ser315 mediate high-level resistance to INH.
Tuberculosis due to resistant Haarlem strain, Tunisia.
Mutations Prevalent among Rifampin- and Isoniazid-Resistant Mycobacterium tuberculosis Isolates from a Hospital in Vietnam.
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Molecular characterisation of Mycobacterium tuberculosis isolates in the First National Survey of Anti-tuberculosis Drug Resistance from Venezuela.
Detection of multidrug resistance in Mycobacterium tuberculosis.
mutations in katG are associated with isoniazid resistance
Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis.
Mutation in katG codon 315 (A->T) leads to isoniazid resistance.
Direct susceptibility testing for multi drug resistant tuberculosis: a meta-analysis.
Mutations in katG gene were detected in Genotype MTBDR and MTBDR plus tests.
Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso.
Pyrosequencing for rapid detection of Mycobacterium tuberculosis resistance to rifampin, isoniazid, and fluoroquinolones.
Associations between Mycobacterium tuberculosis strains and phenotypes.
Mutations in katG gene associated with isoniazid resistance
Determinants of multidrug-resistant tuberculosis clusters, California, USA, 2004-2007.
mutation in katG associated with isoniazid resistance
High-resolution melting curve analysis for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
Mutation in katG gene is associated with isoniazid resistance.
Treatment of tuberculosis with rifamycin-containing regimens in immune-deficient mice.
Mutations in katG gene were identified in isoniazid-resistant Mycobacterium tuberculosis isolates.
Rapid identification of mycobacteria and drug-resistant Mycobacterium tuberculosis by use of a single multiplex PCR and DNA sequencing.
Molecular characteristics of rifampin- and isoniazid-resistant mycobacterium tuberculosis strains isolated in Vietnam.
Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama.
Detected in 1 isolate
Rapid genotypic detection of rpoB and katG gene mutations in Mycobacterium tuberculosis clinical isolates from Northern India as determined by MAS-PCR.
Prevalence of Drug Resistance Mycobacterium Tuberculosis among Patients Seen in Coast Provincial General Hospital, Mombasa, Kenya.
Mutation in katG gene associated with isoniazid resistance.
Comparative proteomic analysis of sequential isolates of Mycobacterium tuberculosis sensitive and resistant Beijing type from a patient with pulmonary tuberculosis.
FIND Tuberculosis Strain Bank: a Resource for Researchers and Developers Working on Tests To Detect Mycobacterium tuberculosis and Related Drug Resistance.
Rapid Sputum Multiplex Detection of the M. tuberculosis Complex (MTBC) and Resistance Mutations for Eight Antibiotics by Nucleotide MALDI-TOF MS.
Comprehensive Whole-Genome Sequencing and Reporting of Drug Resistance Profiles on Clinical Cases of Mycobacterium tuberculosis in New York State.
Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools.
This mutation was identified in strains resistant to isoniazid.
Clinical Outcomes of Patients With Drug-Resistant Tuberculous Meningitis Treated With an Intensified Antituberculosis Regimen.
Mutations in katG were associated with high-level resistance to isoniazid.
Diagnostic Performance of the GenoType MTBDRplus and MTBDRsl Assays to Identify Tuberculosis Drug Resistance in Eastern China.
Genotypic distribution of multidrug-resistant and extensively drug-resistant tuberculosis in northern Thailand.
Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China.
Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods.
All mutations were identified through sequencing and are associated with isoniazid resistance.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Extensively drug resistant tuberculosis in Mali: a case report.
Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.
Comparative Analytical Evaluation of Four Centralized Platforms for the Detection of Mycobacterium tuberculosis Complex and Resistance to Rifampicin and Isoniazid.
Systematic Review of Mutations Associated with Isoniazid Resistance Points to Continuing Evolution and Subsequent Evasion of Molecular Detection, and Potential for Emergence of Multidrug Resistance in Clinical Strains of Mycobacterium tuberculosis.
In-host population dynamics of Mycobacterium tuberculosis complex during active disease.
Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana.
Mutation detected in multiple cases.
Five-year microevolution of a multidrug-resistant Mycobacterium tuberculosis strain within a patient with inadequate compliance to treatment.
Biological and Biochemical Evaluation of Isatin-Isoniazid Hybrids as Bactericidal Candidates against Mycobacterium tuberculosis.
Mutations in katG confer high resistance levels to compounds 11a-h.
Whole genome sequencing of clinical samples reveals extensively drug resistant tuberculosis (XDR TB) strains from the Beijing lineage in Nigeria, West Africa.
Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study.
Putative extensive and pre-extensive drug resistant-tuberculosis associated with unusual genotypes on the Thailand-Myanmar border.
Whole genome sequencing reveals large deletions and other loss of function mutations in Mycobacterium tuberculosis drug resistance genes.
Frameshift mutation in katG associated with isoniazid resistance
Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century.
Whole-Genome Sequencing Has the Potential To Improve Treatment for Rifampicin-Resistant Tuberculosis in High-Burden Settings: a Retrospective Cohort Study.
Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis.
Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.
Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
associated with Isoniazid resistance
Fluoroquinolones and rifampin combination in the backdrop of heteroresistant tuberculosis.
detected in inoculum and non-treated controls
Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.
Genotypic drug resistance and transmission clusters of Mycobacterium tuberculosis isolates among Ethiopian returnees from Saudi Arabia.
A comparative study using Xpert MTB/RIF and culture methods evaluates MassARRAY technology for rapid detection of Mycobacterium tuberculosis and drug resistance.
Evaluation of the Xpert MTB/XDR test for detection of isoniazid, fluoroquinolones, and second-line injectable drugs resistance to Mycobacterium tuberculosis-Anhui Province, China.
Genetic diversity and antibiotic resistance of Mycobacterium bovis in bovines in the Delta area of Egypt.
Mutations in katG were associated with isoniazid resistance in M. bovis isolates.
Tracking the evolution of an extensively drug-resistant cross-border Mycobacterium tuberculosis cluster, Europe, January 2016 up to August 2025: implications for European surveillance.
Characterization of Drug Resistance Patterns, Mutation Profiles and Prevalence of Mycobacterium tuberculosis in Shaoxing.
A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.
All mutations were confirmed by DNA sequencing.
Evaluation of Mycobacterium tuberculosis cross-resistance to isoniazid, rifampicin and levofloxacin with their respective structural analogs.
Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
associated with high-level isoniazid resistance
Molecular detection and characterization of resistant genes in Mycobacterium tuberculosis complex from DNA isolated from tuberculosis patients in the Eastern Cape province South Africa.
Assessment of the genotype MTBDRplus assay for rifampin and isoniazid resistance detection on sputum samples in Cote d'Ivoire.
Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test.
Evaluation of gene mutations involved in drug resistance in mycobacterium tuberculosis strains derived from tuberculosis patients in mazandaran, iran, 2013.
Diversity of Mycobacterium tuberculosis and drug resistance in different provinces of Papua New Guinea.
Mutations found in STR resistant strains.
Added value of whole-genome sequencing for management of highly drug-resistant TB.
Strong evidence for a causal association with a drug-resistant phenotype
Tuberculous spondylitis in Russia and prominent role of multidrug-resistant clone Mycobacterium tuberculosis Beijing B0/W148.
Low resistance to first and second line anti-tuberculosis drugs among treatment naive pulmonary tuberculosis patients in southwestern Uganda.
One isolate showed isoniazid resistance via MTBDR plus, linked to katG mutation
Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.
Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.
Mutations in the katG gene associated with isoniazid resistance
Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations.
mutations in the katG gene are associated with isoniazid resistance
Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis.
Mutations conferring resistance to first- and second-line drugs in multidrug-resistant Mycobacterium tuberculosis clinical isolates in southeast Mexico.
Application of Deletion- Targeted Multiplex PCR technique for detection of Mycobacterium tuberculosis Beijing strains in samples from tuberculosis patients.
Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.
associated with isoniazid resistance
Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.
Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.
associated with isoniazid resistance
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
Evaluation of GenoType MTBDRplus for the rapid detection of drug-resistant tuberculosis in Ghana.
Phenotypic and genotypic analysis of anti-tuberculosis drug resistance in Mycobacterium tuberculosis isolates in Myanmar.
Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates.
Some mutations occur in combination with canonical mutations
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.
The katG mutation was associated with high-level isoniazid resistance.
Reduced turn-around time for Mycobacterium tuberculosis drug susceptibility testing with a proportional agar microplate assay.
Multidrug-Resistant Mycobacterium tuberculosis of the Latin American Mediterranean Lineage, Wrongly Identified as Mycobacterium pinnipedii (Spoligotype International Type 863 [SIT863]), Causing Active Tuberculosis in South Brazil.
Seven isolates carried the S315T mutation in katG
Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.
Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates.
Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment.
Clinical features, Outcomes and Molecular Profiles of Drug Resistance in Tuberculous Meningitis in non-HIV Patients.
mutations at katG315 accounted for 100% of the resistance to isoniazid
Drug resistance characteristics and cluster analysis of M. tuberculosis in Chinese patients with multiple episodes of anti-tuberculosis treatment.
Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae.
Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes.
associated with isoniazid resistance
Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.
Mutations in katG gene contribute to isoniazid resistance.
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.
Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012.
Multi-Fluorescence Real-Time PCR Assay for Detection of RIF and INH Resistance of M. tuberculosis.
Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
Genetic diversity and drug susceptibility profiles of Mycobacterium tuberculosis obtained from Saint Peter's TB specialized Hospital, Ethiopia.
Common mutation in INH resistant isolates
Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.
Confirmed in the study
Retrospective Analysis of Archived Pyrazinamide Resistant Mycobacterium tuberculosis Complex Isolates from Uganda-Evidence of Interspecies Transmission.
Molecular characterisation of multidrug-resistant Mycobacterium tuberculosis isolates from a high-burden tuberculosis state in Brazil.
Mutations in codon 315 were found in 106 isolates (80.9%).
Change in prevalence and molecular characteristics of isoniazid-resistant tuberculosis over a 10-year period in China.
Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistance.
Evaluation of GenoType MTBDRplus for the detection of drug-resistant Mycobacterium tuberculosis on isolates from Karachi, Pakistan.
most frequent mutation
Whole-genome sequencing-based epidemiological analysis of anti-tuberculosis drug resistance genes in Japan in 2007: Application of the Genome Research for Asian Tuberculosis (GReAT) database.
Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.
First insights into the genetic characteristics and drug resistance of Mycobacterium tuberculosis population collected during the first national tuberculosis prevalence survey of Lao PDR (2010-2011).
Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan.
Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa.
Prevalence of mutations in genes associated with rifampicin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.
Spoligotyping and drug sensitivity of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in the Arsi Zone of southeastern Ethiopia.
A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.
Tuberculosis in Liberia: high multidrug-resistance burden, transmission and diversity modelled by multiple importation events.
Evolution of Mycobacterium tuberculosis complex lineages and their role in an emerging threat of multidrug resistant tuberculosis in Bamako, Mali.
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.
Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.
The A479E mutation in katG was found in TCDC4 and TCDC10.
Epidemiological cut-offs for Sensititre susceptibility testing of Mycobacterium tuberculosis: interpretive criteria cross validated with whole genome sequencing.
Isoniazid and Rifampin-Resistance Mutations Associated With Resistance to Second-Line Drugs and With Sputum Culture Conversion.
A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.
Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil.
Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance.
Prevalence of Beijing Central Asian/Russian Cluster 94-32 among Multidrug-Resistant M. tuberculosis in Kazakhstan.
The positivity rates and drug resistance patterns of Mycobacterium tuberculosis using nucleotide MALDI-TOF MS assay among suspected tuberculosis patients in Shandong, China: a multi-center prospective study.
Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.
Mutational Dynamics Related to Antibiotic Resistance in M. tuberculosis Isolates from Serial Samples of Patients with Tuberculosis and Type 2 Diabetes Mellitus.
observed in nine isolates from individuals with DM2-TB and two patients with TB
Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy.
both mutations were experimentally validated
Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study.
Most common mutation in katG
Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia.
Most frequent mutation in INH-resistant isolates
Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.
Genotypic and phenotypic drug resistance patterns of Mycobacterium tuberculosis isolated from presumptive pulmonary tuberculosis patients in Ethiopia: A multicenter study.
Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.
Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance.
These mutations are associated with isoniazid resistance.
Drug Resistance and Epidemiological Success of Modern Mycobacterium tuberculosis Lineages in Western India.
Clonal expansion of Mycobacterium tuberculosis isolates and coexisting drug resistance in patients newly diagnosed with pulmonary tuberculosis in Hanoi, Vietnam.
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from south-central in China.
mutations in the katG gene are associated with isoniazid resistance
Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing.
Mutation in katG associated with isoniazid resistance.
Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.
Direct sequencing for rapid detection of multidrug resistant Mycobacterium tuberculosis strains in Morocco.
Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
In vitro anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene) isonicotinohydrazide derivatives against isoniazid-resistant strains.
Mutation in the coding region of katG
Concomitant multidrug-resistant pulmonary tuberculosis and susceptible tuberculous meningitis.
A multi-site validation in India of the line probe assay for the rapid diagnosis of multi-drug resistant tuberculosis directly from sputum specimens.
Rapid detection of isoniazid resistance in Mycobacterium tuberculosis isolates by use of real-time-PCR-based melting curve analysis.
Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.
Distinguishing nontuberculous mycobacteria from multidrug-resistant Mycobacterium tuberculosis, China.
Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon.
mutated in high level INH-resistant isolates
Molecular patterns of multidrug resistance of Mycobacterium tuberculosis in Georgia.
Most common mutation responsible for INH resistance
Optimizing multiplex SNP-based data analysis for genotyping of Mycobacterium tuberculosis isolates.
Multidrug resistant Mycobacterium tuberculosis: a retrospective katG and rpoB mutation profile analysis in isolates from a reference center in Brazil.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.
Mutation in katG gene associated with high-level isoniazid resistance.
Performance of an Xpert-based diagnostic algorithm for the rapid detection of drug-resistant tuberculosis among high-risk populations in a low-incidence setting.
Mixed Mycobacterium tuberculosis-Strain Infections Are Associated With Poor Treatment Outcomes Among Patients With Newly Diagnosed Tuberculosis, Independent of Pretreatment Heteroresistance.
The katG 315-AGC->ACC mutation was associated with isoniazid resistance.
Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.
Mutations in katG gene were identified in clinical isolates and laboratory strains.
Molecular Analysis of katG Encoding Catalase-Peroxidase from Clinical Isolate of Isoniazid-Resistant Mycobacterium tuberculosis.
A rapid identification technique for drug-resistant Mycobacterium tuberculosis isolates using mismatch specific cleavage enzyme.
Mutations in katG are associated with isoniazid resistance.
Phenotypic and genotypic drug sensitivity of Mycobacterium tuberculosis complex isolated from South Omo Zone, Southern Ethiopia.
Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis.
S315T is a well-known mutation associated with isoniazid resistance.
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe.
Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.
Molecular detection of rifampin, isoniazid, and ofloxacin resistance in Iranian isolates of Mycobacterium tuberculosis by high-resolution melting analysis.
First insights on the genetic diversity of MDR Mycobacterium tuberculosis in Lebanon.
Rapid detection of multidrug resistant tuberculosis in respiratory specimens at a tertiary care centre in south coastal Karnataka using Genotype MTBDR plus assay.
Common mutations in isoniazid resistant isolates
Molecular drug susceptibility testing and strain typing of tuberculosis by DNA hybridization.
Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.
Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.
Lab-on-a-Film disposable for genotyping multidrug-resistant Mycobacterium tuberculosis from sputum extracts.
Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana.
Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East.
Cryptic Resistance Mutations Associated With Misdiagnoses of Multidrug-Resistant Tuberculosis.
noncanonical INH resistance mutation
Prevalence and detection of drug resistant mutations in Mycobacterium tuberculosis among drug naïve patients in Nairobi, Kenya.
Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting.
Acquired at least twice
Rapid screening mutations of first-line-drug-resistant genes in Mycobacterium tuberculosis strains by allele-specific real-time quantitative PCR.
Isoniazid Resistance in Mycobacterium tuberculosis Is a Heterogeneous Phenotype Composed of Overlapping MIC Distributions with Different Underlying Resistance Mechanisms.
Mutations in katG contribute to isoniazid resistance.
Speeding up the diagnosis of multidrug-resistant tuberculosis in a high-burden region with the use of a commercial line probe assay.
High prevalence of multi drug resistant tuberculosis in people living with HIV in Western India.
Mutations in katG gene were identified as a cause of isoniazid resistance.
Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province, China.
Genomic characterization of MDR/XDR-TB in Kazakhstan by a combination of high-throughput methods predominantly shows the ongoing transmission of L2/Beijing 94-32 central Asian/Russian clusters.
First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Kuwait and evaluation of REBA MTB-MDR assay for rapid detection of MDR-TB.
In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis.
Mutations at codon 315 of katG
Prevalence and genetic basis of first-line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam.
MycoVarP: Mycobacterium Variant and Drug Resistance Prediction Pipeline for Whole-Genome Sequence Data Analysis.
Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
associated with isoniazid resistance
Comparative genomics of drug-resistant strains of Mycobacterium tuberculosis in Ecuador.
The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development.
S315T mutation reduces INH affinity
Ultrasensitive Detection of Multidrug-Resistant Mycobacterium tuberculosis Using SuperSelective Primer-Based Real-Time PCR Assays.
Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis.
All mutations were identified in the katG gene and are associated with isoniazid resistance.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases.
Clinical Evaluation of the XDR-LFC Assay for the Molecular Detection of Isoniazid, Rifampin, Fluoroquinolone, Kanamycin, Capreomycin, and Amikacin Drug Resistance in a Prospective Cohort.
New insights on tuberculosis transmission dynamics and drug susceptibility profiles among the prison population in Southern Brazil based on whole-genome sequencing.
Clinical utility of target-based next-generation sequencing for drug-resistant TB.
Mutations in katG were identified as a key determinant of isoniazid resistance.
A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.
Consistent with phenotypic results
Discrepancy in the transmissibility of multidrug-resistant mycobacterium tuberculosis in urban and rural areas in China.
Increased MDR-TB transmission in Wusheng
FLASH-TB: an Application of Next-Generation CRISPR to Detect Drug Resistant Tuberculosis from Direct Sputum.
Drug Resistance in Tuberculous Lymphadenitis: Molecular Characterization.
Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study.
Mutations in katG are associated with isoniazid resistance.
Heteroresistance to rifampicin & isoniazid in clinical samples of patients with presumptive drug-resistant tuberculosis in Central India.
Mycobacterium tuberculosis Adaptation in Response to Isoniazid Treatment in a Multi-Stress System That Mimics the Host Environment.
The MDR strain has an amino acid change in KatG (S315T).
Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster.
Rapid Identification of Lineage and Drug Resistance in Clinical Samples of Mycobacterium tuberculosis.
The mutation katG (Ser315Arg) was not described as conferring resistance, but the strain was isoniazid-resistant.
Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis.
Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis.
Isoniazid resistance-conferring mutations are associated with highly variable phenotypic resistance.
KatG Ser315Thr mutation
Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
Phenotypic Drug Resistance Pattern and Mutation Characteristics of Mycobacterium tuberculosis from Different Body Fluids Among Extra Pulmonary Patients Presented in Selected Hospitals in Addis Ababa, Ethiopia.
Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.
Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.
Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China.
Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants.
Detected in 65/1831 strains
Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis.
Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.
Drug resistance and the genotypic characteristics of rpoB and katG in rifampicin- and/or isoniazid-resistant Mycobacterium tuberculosis isolates in central Vietnam.
The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.
A preliminary evaluation of targeted nanopore sequencing technology for the detection of Mycobacterium tuberculosis in bronchoalveolar lavage fluid specimens.
Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.
Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.
mutations in katG are associated with isoniazid resistance
Machine learning and phylogenetic analysis allow for predicting antibiotic resistance in M. tuberculosis.
associated with resistance to aminoglycosides and other drugs
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.
loss-of-function mutations
Insights into the in-vitro Susceptibility and Drug-Drug Interaction Profiles Against Drug-Resistant and Susceptible Mycobacterium tuberculosis Clinical Isolates in Amhara, Ethiopia.
First evaluation of an improved assay for molecular genetic detection of tuberculosis as well as rifampin and isoniazid resistances.
Use of a molecular diagnostic test in AFB smear positive tuberculosis suspects greatly reduces time to detection of multidrug resistant tuberculosis.
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated in Nepal.
Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.
Mutations in katG are associated with high-level isoniazid resistance
Estimating fitness by competition assays between drug susceptible and resistant Mycobacterium tuberculosis of predominant lineages in Mumbai, India.
Comparison of line probe assay with liquid culture for rapid detection of multi-drug resistance in Mycobacterium tuberculosis.
Mutation in katG gene confers resistance to isoniazid.
Isoniazid MIC and KatG Gene Mutations among Mycobacterium tuberculosis Isolates in Northwest of Iran.
mutations in KatG gene lead to resistance
Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.
From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study.
Epidemiology of isoniazid resistance mutations and their effect on tuberculosis treatment outcomes.
MDR TB transmission, Singapore.
Resistance of Mycobacterium tuberculosis to antibiotics in Lao PDR: first multicentric study conducted in 3 hospitals.
The S315T mutation in katG is a well-known mutation associated with isoniazid resistance.
Multidrug-resistant tuberculosis in panama is driven by clonal expansion of a multidrug-resistant Mycobacterium tuberculosis strain related to the KZN extensively drug-resistant M. tuberculosis strain from South Africa.
A simple, rapid and economic method for detecting multidrug-resistant tuberculosis.
Detected in 69 isolates
Magnitude of gene mutations conferring drug resistance in mycobacterium tuberculosis isolates from lymph node aspirates in ethiopia.
Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
All inhA mutations were associated with a Ser315Thr mutation in katG except for 1 isolate in which katG did not amplify.
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
Mutations in katG confer resistance to isoniazid
Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.
The katG gene encodes a enoyl-(acyl-carrier-protein) reductase involved in mycolic acid synthesis. Mutations in katG, such as S315T, are associated with resistance to isoniazid.
Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.
Cases 2 and 3
High-resolution melting analysis for molecular detection of multidrug resistance tuberculosis in Peruvian isolates.
Diagnostic Molecular Mycobacteriology in Regions With Low Tuberculosis Endemicity: Combining Real-time PCR Assays for Detection of Multiple Mycobacterial Pathogens With Line Probe Assays for Identification of Resistance Mutations.
Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis.
Detected in 54.5% of Brazilian and 84.2% of Mozambican isolates.
Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.
Effect of efflux pump inhibitors on the susceptibility of Mycobacterium tuberculosis to isoniazid.
What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis.
Evaluation of Whole-Genome Sequencing for Mycobacterial Species Identification and Drug Susceptibility Testing in a Clinical Setting: a Large-Scale Prospective Assessment of Performance against Line Probe Assays and Phenotyping.
Molecular & genetic characteristics of Mycobacterium tuberculosis strains circulating in the southern part of West Siberia.
Rapid Microarray-Based Detection of Rifampin, Isoniazid, and Fluoroquinolone Resistance in Mycobacterium tuberculosis by Use of a Single Cartridge.
Mutations in katG were analyzed for their association with resistance to isoniazid.
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations.
Mutations promoted from gene entry 'katG' (model emitted mutations_found inside genes).
Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.
Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis.
The katG315 mutation was significantly associated with isoniazid resistance in the study.
Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.
Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG.
Mutations in katG associated with isoniazid resistance
Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.
associated with high-level resistance
Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates.
Genotyping and molecular detection of multidrug-resistant Mycobacterium tuberculosis among tuberculosis lymphadenitis cases in Addis Ababa, Ethiopia.
detected in all isoniazid-resistant isolates
Experimental platform utilising melting curve technology for detection of mutations in Mycobacterium tuberculosis isolates.
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
S315T mutation reduces the ability of KatG to convert INH into isonicotinic acid.
Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?
Mutations in katG are associated with resistance to IQG-607 and INH.
Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.
Most frequent mutation related to isoniazid resistance in both Brazil and Mozambique
Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.
Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.
Mutations in katG gene associated with isoniazid resistance.
Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.
Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.
Metabolic Changes of Mycobacterium tuberculosis during the Anti-Tuberculosis Therapy.
Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan
Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015.
Mutations promoted from gene entry 'katG' (model emitted mutations_found inside genes).
A Benchtop Automated Sputum-to-Genotype System Using a Lab-on-a-Film Assembly for Detection of Multidrug-Resistant Mycobacterium tuberculosis.
Artificial Intelligence and Machine learning based prediction of resistant and susceptible mutations in Mycobacterium tuberculosis.
Accuracy of a reverse dot blot hybridization assay for simultaneous detection of the resistance of four anti-tuberculosis drugs in Mycobacterium tuberculosis isolated from China.
Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.
Mutation in katG is associated with isoniazid resistance.
Whole Genome and Transcriptome Sequencing of Two Multi-Drug Resistant Mycobacterium tuberculosis Strains to Facilitate Illustrating Their Virulence in vivo.
Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.
Present in GC2 isolates.
Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.
Xpert Mycobacterium tuberculosis/Rifampicin-Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.
Spoligotype and Drug Susceptibility Profiles of Mycobacterium tuberculosis Complex Isolates in Golestan Province, North Iran.
Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia.
Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance.
Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.
Rapid Identification of Drug-Resistant Tuberculosis Genes Using Direct PCR Amplification and Oxford Nanopore Technology Sequencing.
Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan.
A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis.
Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.
Mutation associated with isoniazid resistance.
Isolation of multidrug-resistant (MDR) Mycobacterium bovis from a dog in Korea
Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.
Most prevalent mutation
Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
mutations in katG are associated with isoniazid resistance
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.
Mutation in katG is associated with isoniazid resistance.
Evaluation of whole-genome sequence to predict drug resistance of nine anti-tuberculosis drugs and characterize resistance genes in clinical rifampicin-resistant Mycobacterium tuberculosis isolates from Ningbo, China.
Minimum inhibitory concentrations of rifampin and isoniazid among multidrug and isoniazid resistant Mycobacterium tuberculosis in Ethiopia.
mutations in katG gene are the major genetic mutations in MDR TB
Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
Deep Amplicon Sequencing Reveals Culture-dependent Clonal Selection of Mycobacterium tuberculosis in Clinical Samples.
Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.
The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.
Targeted next-generation sequencing of Mycobacterium tuberculosis from patient samples: lessons learned from high drug-resistant burden clinical settings in Bangladesh.
Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.
The performance of Xpert MTB/RIF and MTBDRplus within a Programmatic setting at TB Laboratory in Rio de Janeiro, Brazil.
The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 drugs in China from a nationwide survey: a genomic analysis.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Identification and analysis of mutations in the katG gene in multidrug-resistant Mycobacterium tuberculosis clinical isolates.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
The mutations of katG and inhA genes of isoniazid-resistant Mycobacterium tuberculosis isolates in Taiwan.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Characterization of a Clone of Mycobacterium tuberculosis Clinical Isolates with Mutations in KatG (A110V), EthA (Q269STOP), and the inhA Promoter (-15C→T).
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Detection of novel coupled mutations in the katG gene (His276Met, Gln295His and Ser315Thr) in a multidrug-resistant Mycobacterium tuberculosis strain from Chennai, India, and insight into the molecular mechanism of isoniazid resistance using structural bioinformatics approaches.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Biological and molecular characteristics of Mycobacterium tuberculosis clinical isolates with low-level resistance to isoniazid in Japan.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Ontario, Canada.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Detection of novel mutations associated with independent resistance and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide; CARD accession: CARD:3005102
First genetic characterisation of multidrug-resistant Mycobacterium tuberculosis isolates from Algeria.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Novel mutations detected from drug resistant Mycobacterium tuberculosis isolated from North East of Thailand.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
The MTB/MDR ELITe MGB(®) Kit: Performance Assessment for Pulmonary, Extra-Pulmonary, and Resistant Tuberculosis Diagnosis, and Integration in the Laboratory Workflow of a French Center.
Mutations in the katG gene were not probed by the test, leading to false INH susceptibility results.
Combination of commercially available molecular assays and culture based methods in diagnosis of tuberculosis and drug resistant tuberculosis.
All seven INH-resistant isolates demonstrated the same mutation in the promoter region of inhA gene (A-16G).
Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation.
Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: A retrospective cohort study.
Mutations in katG were identified in 33 (40.7%) of patients.
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
Multiple mutations in katG codon 315 were identified, including S315T, S315N, and S315R.
Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.
Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.
Variant S315T in katG gene causes resistance to isoniazid.
A systematic follow-up of Mycobacterium tuberculosis drug-resistance and associated genotypic lineages in the French Departments of the Americas over a seventeen-year period.
Mutation detected in 5 MDR strains.
Molecular epidemiology of Mycobacterium tuberculosis complex in the Volta Region of Ghana.
MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.
Identification of virulence and antibiotic resistance factors in Arcobacter butzleri isolated from bovine milk by Whole Genome Sequencing.
Mutations in katG gene confer resistance to isoniazid.
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.
Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.
Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis.
mutation in katG leading to isoniazid resistance
Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences.
Applying whole genome sequencing to predict phenotypic drug resistance in Mycobacterium tuberculosis: leveraging 20 years of nationwide data from Denmark.
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population.
Mutations in katG are associated with isoniazid resistance.
Anti-tuberculosis drug resistance in Slovakia, 2018-2019: The first whole-genome epidemiological study.
Genomic Analysis of Multidrug-Resistant Mycobacterium tuberculosis Strains From Patients in Kazakhstan.
Mutations found in all eight MDR-TB isolates.
A molecular platform for the diagnosis of multidrug-resistant and pre-extensively drug-resistant tuberculosis based on single nucleotide polymorphism mutations present in Colombian isolates of Mycobacterium tuberculosis.
Drug resistance profile of Mycobacterium tuberculosis complex isolated from pulmonary tuberculosis patients and their household contacts in central Ethiopia.
All cases of INH resistance were linked to katG mutations.
In vitro modeling of isoniazid resistance mechanisms in Mycobacterium tuberculosis H37Rv.
Detected in passage 4
Diagnostic performance of the Sanity 2.0 assay to detect resistance to rifampicin, isoniazid, and fluoroquinolones in tuberculosis.
Detected in discrepant cases where the assay missed the mutation.
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.
Evaluation of genotype MTBDRplus assay for rapid detection of isoniazid and rifampicin resistance in Mycobacterium tuberculosis clinical isolates from Pakistan.
Direct detection from sputum for drug-resistant Mycobacterium tuberculosis using a CRISPR-Cas14a-based approach.
Mutation detected in INH-resistant isolates.
First-line drug resistance profiling of Mycobacterium tuberculosis: a machine learning approach.
Deciphering the population dynamics and drug-resistance characteristics of extrapulmonary tuberculosis: genomic and clinical insights from a Chinese hospital.
Molecular detection of Mycobacterium tuberculosis sensitivity to rifampicin and isoniazid in South Gondar Zone, northwest Ethiopia.
All INH-resistance conferred by mutations at katG gene.
Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis.
dominant INH resistance mutation
Molecular epidemiology of Mycobacterium tuberculosis, Buenos Aires, Argentina.
Whole Genome Sequencing of Drug Resistant and Drug Susceptible Mycobacterium tuberculosis Isolates From Tigray Region, Ethiopia.
major resistance mutation
Redefining MTBDRplus test results: what do indeterminate results actually mean?
mutations in katG confer resistance to isoniazid
Mycobacterium tuberculosis Drug Resistance and Transmission among Human Immunodeficiency Virus-Infected Patients in Ho Chi Minh City, Vietnam.
Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.
Whole genome sequencing of Mycobacterium tuberculosis isolates and clinical outcomes of patients treated for multidrug-resistant tuberculosis in Tanzania.
Mutation in katG gene associated with isoniazid resistance.
Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity.
Establishment and evaluation of an overlap extension polymerase chain reaction technique for rapid and efficient detection of drug-resistance in Mycobacterium tuberculosis.
Molecular characterization of genetic mutations with fitness loss in pulmonary tuberculosis patients associated with HIV co-infection in Northwest Amhara, Ethiopia.
Detected in MDR-TB isolates
Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains.
Evaluation of microscopic observation drug susceptibility assay for diagnosis of multidrug-resistant tuberculosis in Viet Nam.
Mutation in katG gene
[Metastases to the mediastinal lymph nodes in a series of two-hundred-consecutive operations for primary lung cancer].
Tuberculosis drug resistance mutation database.