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Browse Mutations katGP232L

GenekatG

Protein ChangeP232L

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced INH-KatG binding affinity
Resistance To: isoniazid
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy.

PMID 38466098 · 2024

both mutations were experimentally validated

Mutation Information

Protein Change: P232L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: isoniazid
Effect on Function: reduced INH-KatG binding affinity
Validation Method: transformation experiments
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research