ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeQ439H

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: isoniazid
Organisms: Mycobacterium tuberculosis
Papers: 2

Paper Information2

Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation.

PMID 30606210 · 2019

Mutation Information

katG: p.Q439H / c.C1317A

Protein Change: Q439H
Nucleotide Change: C1317A
Confers Resistance To: isoniazid
Validation Method: sequencing and phenotypic correlation
Source Database: Reslit

Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis.

PMID 36635309 · 2023

All mutations were identified in the katG gene and are associated with isoniazid resistance.

Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392

Mutation Information

katG: p.Q439H

Protein Change: Q439H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: isoniazid
Effect on Function: single resistance variant
Validation Method: genotypic resistance prediction using TB-Profiler software and phenotypic DST data
Source Database: ReslitCard Database

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