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Browse Mutations katGG421D

GenekatG

Protein ChangeG421D

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: isoniazid
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Biological and Biochemical Evaluation of Isatin-Isoniazid Hybrids as Bactericidal Candidates against Mycobacterium tuberculosis.

PMID 33972252 · 2021

Mutations in katG confer high resistance levels to compounds 11a-h.

Mutation Information

Protein Change: G421D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: isoniazid
Validation Method: selection of resistant mutants and sequencing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research