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Browse Mutations ramR517_518del

GeneramR

Nucleotide Change517_518del

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reducing its ability to inhibit the AcrAB-TolC efflux pump
Resistance To: tigecycline
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

A novel mutation of ramR involved in tigecycline resistance in Klebsiella pneumoniae.

PMID 40372027 · 2025

The mutation leads to a truncated RamR protein, reducing its ability to inhibit the AcrAB-TolC efflux pump.

Mutation Information

ramR: c.517_518del

Nucleotide Change: 517_518del
Organisms: Klebsiella pneumoniae
Confers Resistance To: tigecycline
Effect on Function: reducing its ability to inhibit the AcrAB-TolC efflux pump
Validation Method: gene knockout and complementation experiments
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research