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Browse Mutations pncAH51A

GenepncA

Protein ChangeH51A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disrupts metal ion binding and catalytic activity
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Papers: 1

Paper Information1

1

Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide.

PMID 21283666 · 2011

Mutations in pncA are responsible for pyrazinamide resistance in M. tuberculosis.

Mutation Information

Protein Change: H51A
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Confers Resistance To: pyrazinamide
Effect on Function: disrupts metal ion binding and catalytic activity
Validation Method: site-directed mutagenesis and kinetic assays
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research