pncA

pyrazinamidase

Overview

Mechanism: missense mutation
Drug Classes: pyrazinamide, pza
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium fortuitum, Mycobacterium canettii, Mycobacterium avium, Mycobacterium abscessus, Mycobacterium intracellulare, Mycobacterium kansasii, Mycobacterium malmoense, Mycobacterium xenopi, Mycobacterium marinum, Mycobacterium africanum
Papers: 189
Mutations: 737

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R140S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G97S	-	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
W68*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A46V	C137T C138T	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
D12A	A35C	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D53A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
Q10R	A31G C30T	loss of PZAse activity, resistant, single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
H82R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L85R	T254G	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
V155G	T464G	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
T168N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V130G	T389G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G132D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H51R	-	loss of PZAse activity, loss of activity, resistant, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G132A	G395C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
I31S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
I31T	T92C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L19R	T56G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L27P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L35P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V45A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A46S	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S67P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H71D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C72Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G74R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S104R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G122S	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V125F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
E127*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V139G	T416G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T142M	C425T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A146T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T174I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G162S	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G17D	G51A	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
T168I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V147I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
H57R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T54A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T34I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G162D	G487A	missense mutation, single resistance variant	Mycobacterium tuberculosis	pzapyrazinamide	ReslitCard Database	Candidate
Q10P	A29C A31C C30T	resistant, single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T76P	A226C	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G108R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A134V	-	loss of PZAse activity, disrupts catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	ReslitCard Database	Candidate
L4S	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H51Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V180A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D136Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G105V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H51D	CAG->GAT	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H51P	A152C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D8H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C138R	T412C T414C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A46E	C137T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A46P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L116P	T347C	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
W119G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
W119L	G356T	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L120P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V128A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V128G	GTG->GGA T383G	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
D49N	-	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
Y64S	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
W68G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
F94A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
E112K	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Q141P	A422C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D126N	G376A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T47P	A139C	single resistance variant	Mycobacterium tuberculosis	pzapyrazinamide	ReslitCard Database	Candidate
C14Y	G41A	single resistance variant	Mycobacterium tuberculosis	pzapyrazinamide	ReslitCard Database	Candidate
W119R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D49A	A146C GAT->GCA	single resistance variant	Mycobacterium tuberculosis	pzapyrazinamide	ReslitCard Database	Candidate
H57D	C170G	reduces PncA activity, disrupts metal ion binding and catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	ReslitCard Database	Candidate
D63G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
K96T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T135P	A403C	loss of PZAse activity, loss of activity, decreased ability to hydrolyze PZA, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
F94L	-	reduced binding affinity of PZA to PZase, loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
F94S	-	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
K96N	-	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
K96R	-	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G97C	G289T	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G97D	G289A	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T62A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
548fs	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
K45K	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A440T	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R212R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
P54L	C161T	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pzapyrazinamide	ReslitCard Database	Candidate
W12R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L12R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
W68L	-	reduce the binding affinity of pyrazinamide (PZA) to the enzyme, disrupts substrate binding and catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	ReslitCard Database	Candidate
G24D	-	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D12G	-	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C14G	-	loss of PZAse activity	Mycobacterium tuberculosis	pyrazinamidepza	Reslit	Candidate
Y34D	T100G	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
K48T	A144G	loss of PZAse activity, loss of activity, susceptible, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G78C	-	loss of PZAse activity, loss of activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
P62L	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L85P	TTG->CCC	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
H71Y	C211T	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G105D	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D136G	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H137P	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V7I	-	loss of PZAse activity	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V7F	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V139A	G416C T419C	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
T142P	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V155A	-	loss of PZAse activity, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L172P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
F94C	T280G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A46A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
I90S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A92P	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T168P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
M306I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
M306V	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
E504D	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A145V	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A146V	C437T	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
L151S	T452C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
R154G	A460G	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
A102V	C305T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
S59P	T175C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
E91Q	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V130A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
E15G	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T47I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S65S	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
C104R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T153H	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R154W	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A121D	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
I31F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V154A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S59Y	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S67W	C200G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L76P	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G78R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
D86G	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V93A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
S104G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V125A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V130M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G132G	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
C138G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T142R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T167I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L159V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V21G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A107G	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
I5S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H57P	A170C	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
W68R	T202C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
M18V	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L120R	T359G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G10P	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V180F	G538T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
Y10*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V93L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A3E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H51Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C72W	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G132S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
I133T	T398C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
R148S	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
M175V	A523G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D53N	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A26G	-	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D49G	A147G A148G	disrupts metal ion binding and catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamidepza	ReslitCard Database	Candidate
D8L	-	disrupts catalytic activity	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	Reslit	Candidate
D8E	-	disrupts catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	ReslitCard Database	Candidate
K96Q	A286C	disrupts catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	ReslitCard Database	Candidate
C138A	-	disrupts catalytic activity	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	Reslit	Candidate
H51A	-	disrupts metal ion binding and catalytic activity	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	Reslit	Candidate
F13L	-	disrupts substrate binding and catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	ReslitCard Database	Candidate
T61P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H82D	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
C138Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
N36S	-	-	Mycobacterium tuberculosis	pza	Reslit	Candidate
G37R	-	-	Mycobacterium tuberculosis	pza	Reslit	Candidate
C14R	T40C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C14*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G139D	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A3P	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
I6T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T114M	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A171V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L182S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L10R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V125G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T160M	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T167A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V7G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D8G	A25G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C14W	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T47A	A139G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
P54Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
P62T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H71R	A212G	resistant, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T76I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D110G	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T114P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L116R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G132C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H137R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V139M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T142A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T142K	-	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V157G	T470G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
M175T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L182W	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
S59F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
F81S	-	susceptible, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H82Y	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Y103C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A143T	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S95T	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A106V	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V139L	G417T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H43Y	-	-	-	pza	Reslit	Candidate
E15*	-	-	-	pza	Reslit	Candidate
N11S	-	-	-	pza	Reslit	Candidate
G78V	G233T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A36T	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V115A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A134T	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Q96P	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Y103D	T309G	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A172G	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Q10H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L4W	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G78S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
M175I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
S67*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V44A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Q122H	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R106H	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L910P	-	-	Mycobacterium fortuitum	pyrazinamide	Reslit	Candidate
G17S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
K48N	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V180G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T160A	A478G	-	Mycobacterium tuberculosis	pyrazinamidepza	Reslit	Candidate
T100I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Y99fs	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
N149fs	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R154M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L172fs	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G108E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H43P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
P69L	C205T CCG->CTT	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
H137Y	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G172R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G113F	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R121L	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A161P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
H137D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
480fs	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Y64D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V131G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
S450L	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
M117T	-	-	Mycobacterium canettii	pyrazinamide	Reslit	Candidate
D12E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L159R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V130E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
Q122*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Y103*	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
T159A	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A134R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V163A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
T153I	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
F106S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
G171A	G514A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
K19R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
P62S	-	susceptible, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C96E	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V155M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
N11K	C33A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
P69T	C205A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R140H	G419A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
E144K	G430A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L35R	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
D63A	A188C GAT->GCA	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	ReslitCard Database	Candidate
G78D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
R140G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
L19P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
V7A	T20C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
A30V	-	single resistance variant	Mycobacterium tuberculosis	pzapyrazinamide	ReslitCard Database	Candidate
F106L	-	single resistance variant	Mycobacterium tuberculosis	pzapyrazinamide	ReslitCard Database	Candidate
D63H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
C138S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
P69Q	-	single resistance variant	Mycobacterium bovis, Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
I49V	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
Q10K	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
D136N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	ReslitCard Database	Candidate
Y34Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y34S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y41Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V44G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
K48E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D49E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P54T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P54S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P54R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H57Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H57L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H57Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F58L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F58S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F58C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P62R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y64Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S66Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S66P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S67Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
W68Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S88Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C72R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
W68C	G204T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
H71P	A212C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
H71E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A146E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D136fs	-	frameshift mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D8N	G22A G23A	single resistance variant	Mycobacterium tuberculosis	pyrazinamidepza	Card DatabaseReslit	Candidate
G108Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I5T	T14C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
L117fs	-	frameshift mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P69R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S164Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T100P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T114fs	-	frameshift mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V131fs	-	frameshift mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y103Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E174G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A161G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C138W	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
K96M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S164P	T490C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
D63Y	-	multiple resistance variants, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V9A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Q122Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V7L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D8Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D8A	GAT->GCA	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
V9G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Q10Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D12N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F13I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F13S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C14Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E15Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S18Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
R121P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y99Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E144Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L159P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T160K	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T160P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A171E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A171T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A171P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E173Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D136H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E174Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
M175R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D49V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T177P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E181Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G23V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
M1Var	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
K96E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S104C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T47S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V125D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V7D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y103H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y41H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F81V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G97R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Q141Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S32I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H71Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P62Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
R123P	G368C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
T135N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E37Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E91Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F106Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F13V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F13Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F58I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G101Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G101E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G105R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G124S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G132R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G132V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G162A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G162V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G16R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G16V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G17C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G24V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G55C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G75V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H42N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H42Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H43Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H51L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H51N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H57N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H71L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H71N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
H82L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I133F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I133N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I31N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I52T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I5F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I5M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I5N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I6F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I6M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
K48Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
K96Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L116Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L117Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L120Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L151Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L156P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L156R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L159Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L19Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L27Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L4Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L4F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L4V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L85Q	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
M175K	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
M1L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
N112S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A134P	G402C	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
N118Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
N11T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
N149I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
N149Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P115A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P115R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P62A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A143D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P70A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P70S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P77S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Q10E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Q10L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Q122K	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
R123S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
R140P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
R176P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
R29C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A146S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S164T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S179N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S186F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S18L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S18T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S32N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S65F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S88T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T114A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T135I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T135S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A152V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T153N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T160R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T22I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
T76S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V109L	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V128D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V131D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V131F	G391T	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
V131I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A165D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V139E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V147A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V155E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V163E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V180D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V183D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V21A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A170S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V21E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V44D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V93E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
W119Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A170V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y95Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A26V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A28S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A30P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A30S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A36D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A36S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A38G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A38S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A79P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A89V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A92E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C138Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C138F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C184R	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C72Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
C72F	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D110E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D110H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D110N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D129E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D12H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D12Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D136V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D145E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D158G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D166V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D49H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D49Y	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D63E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D80H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D86V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D8V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E111Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E127Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E127D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E173G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E174K	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E181K	G541A	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
N118T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I90T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
I90N	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
P62H	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
L172A	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y103S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
W68S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
V45G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A25E	-	multiple resistance variants	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A28D	-	multiple resistance variants	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y95D	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
Y99D	-	multiple resistance variants	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
M1S	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
F94P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A102T	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
G97V	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
A102P	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
S104I	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
E107Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
W119C	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
D129N	G385A	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Candidate
A143G	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Candidate
-	312insG	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	313insG	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	386_394del	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	389delT	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	403-414delACCGATCATTG	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	407insA	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	407insTCATTGTGTGCGCCAGACGGC	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	408insA	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	446_453del	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	448insG	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	456insC	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	459-467delCAGGGTGC	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	515del	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	515insG	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A-11C	-	Mycobacterium tuberculosis	pyrazinamide	ReslitResFinder Database	Candidate
-	A-11G	loss of pncA expression	Mycobacterium tuberculosis	pyrazinamide	ReslitResFinder Database	Candidate
-	A10G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A12A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A152G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
I6L	A16C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
N76H	A226C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A226C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A245G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
H82P	A246C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A286G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A287C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A29C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A33G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A340C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
K114R	A340G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A407G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
N137S	A410G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A422C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A457C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A49G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A521G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S179C	A535G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A63A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	A87T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C-11T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C-128T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C-12T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C-159T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C-34T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C-7T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C129A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
P46Q	C137A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C138T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C151G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C151T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C160T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C161A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C169G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C312A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R106K	C317T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A134D	C401A C403A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
409fs	C409G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C421T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C425T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C42A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C437A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A156G	C468G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
S18*	C53A	-	Mycobacterium tuberculosis	pzapyrazinamide	Reslit	Candidate
-	C83A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	C89A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R188Q	CGG->CAA	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G-33A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G36D	G106A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G37V	G109T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A46T	G136A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G13A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G21del	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G290A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
I104S	G311T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G313T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G331T	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G332A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R112H	G336A	-	Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium abscessus, Mycobacterium intracellulare, Mycobacterium kansasii, Mycobacterium malmoense, Mycobacterium xenopi, Mycobacterium marinum, Mycobacterium fortuitum	pyrazinamide	Reslit	Candidate
-	G34A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G395A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G136D	G406A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G415A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G427C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
G150A	G449C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
R154T	G461C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G485A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
A170P	G508C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
E173E	G519A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	G97A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	GAA->TGA	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	GCC->ACT	-	-	pza	Reslit	Candidate
G176D	GGT->GAT	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T-10C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	T-12C	-	Mycobacterium tuberculosis	pyrazinamide	ReslitResFinder Database	Candidate
-	T-12G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	T-7C	-	Mycobacterium tuberculosis	pyrazinamide	ReslitResFinder Database	Candidate
-	T103G	-	Mycobacterium africanum	pyrazinamide	Reslit	Candidate
-	T104C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T12C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T142A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T14C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T160A	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
F68R	T202G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T20G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T269G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
V93G	T278G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T347G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T355G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
L13P	T38C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T398C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T416C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T416G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T4C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T546C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T56C	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	T68G	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
-	del118GACTACCATCACGTCGTGGCAACCAAGGACTTC	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del158A	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del161C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del162G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del172T	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del1ATGCGGGC	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del1ATGCGGGCGTT	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del239A	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del288G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del28C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del307TACAG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del312C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del341C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del379GAGGTCGATGT	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del381GG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del386ATGT	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del391G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del395GTATTGCCACC	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del406G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del416TG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del436G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del443G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del446ATGGCTTG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del452T	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del475C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del47G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del512C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del59C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del64A	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del70G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del71G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del84C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	del88GCCATCAGCGACTACCTGGCCGAA	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins101T	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins137G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins163T	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins193A	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins219CGCATTGCCG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins222G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins288T	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins302A	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins302G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins307C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins369AG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins369NNNNNNNNNNNNNNNNNN	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins383AG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins389AGGTCGATG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins389GAGGTCGAT	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins392GG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins393G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins398T	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins404C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins408C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins415G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins421G	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins421GG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins429GG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins466T	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins481TGAC	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins502GC	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins519NNNNN	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins533C	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate
-	ins53GG	-	Mycobacterium tuberculosis	pyrazinamide	ResFinder Database	Candidate

Papers189

pncA Mutations as a Major Mechanism of Pyrazinamide Resistance in Mycobacterium tuberculosis: Spread of a Monoresistant Strain in Quebec, Canada.

PMID 10681313 · 2000

The study confirms that pncA mutations are the major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.R140S pncA: p.G97S pncA: p.W68*pncA: p.A46V pncA: p.D12A pncA: p.D53A pncA: p.Q10R pncA: p.H82R pncA: p.L85R pncA: p.V155G pncA: p.T168N pncA: p.V130G pncA: p.C138S pncA: p.A134V pncA: p.H71E

Protein Change: R140S, G97S, W68*, A46V, D12A, D53A, Q10R, H82R, L85R, V155G, T168N, V130G, C138S, A134V, H71E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Validation Method: sequencing
Source Database: ReslitCard Database

Genetic diversity and evidence for acquired antimicrobial resistance in Mycobacterium tuberculosis at a large hospital in South India.

PMID 11179917 · 2000

Mutation Information

pncA: p.G132D pncA: p.H51R

Protein Change: G132D, H51R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

PMID 19890396 · 2009

Mutation Information

pncA: p.G132A

Protein Change: G132A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Surveillance of pyrazinamide susceptibility among multidrug-resistant Mycobacterium tuberculosis isolates from Siriraj Hospital, Thailand.

PMID 20727143 · 2010

Some mutations were not associated with resistance and could lead to misinterpretation of the genotypic methods.

Mutation Information

Protein Change: I31S, I31T, L19R, L27P, L35P, V45A, A46S, S67P, H71D, C72Y, G74R, G97S, S104R, G122S, V125F, E127*, V139G, T142M, A146T, T174I
Nucleotide Change: A-11C, A-11G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

Comprehensive multicenter evaluation of a new line probe assay kit for identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis.

PMID 22205814 · 2012

Mutations in pncA were associated with pyrazinamide resistance.

Mutation Information

pncA: p.G162S pncA: p.G17D pncA: p.T168I pncA: p.G132D pncA: p.V147I

Protein Change: G162S, G17D, T168I, G132D, V147I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: LiPA and DNA sequencing
Source Database: Reslit

A new approach for pyrazinamide susceptibility testing in Mycobacterium tuberculosis.

PMID 22372927 · 2012

Mutations in pncA were associated with reduced pyrazinamidase activity and increased pyrazinamide resistance.

Mutation Information

pncA: p.H57R

Protein Change: H57R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: measured POA efflux rate and BACTEC460 susceptibility
Source Database: Reslit

Drug-resistant tuberculosis transmission and resistance amplification within families.

PMID 22840848 · 2012

Mutation Information

pncA: p.T54A pncA: p.T34I

Protein Change: T54A, T34I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.

PMID 29188195 · 2017

Mutation Information

pncA: p.G162D

Protein Change: G162D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Effect on Function: missense mutation
Validation Method: Sanger sequencing and MIC testing
Source Database: Reslit

Genetic Identification and Drug-Resistance Characterization of Mycobacterium tuberculosis Using a Portable Sequencing Device. A Pilot Study.

PMID 32867304 · 2020

Mutation in pncA gene associated with pyrazinamide resistance.

Mutation Information

pncA: p.Q10P

Protein Change: Q10P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing and analysis using MinION and previous whole genome analysis
Source Database: Reslit

Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany.

PMID 33903103 · 2021

Mutation Information

pncA: p.T76P

Protein Change: T76P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Overcoming the Challenges of Pyrazinamide Susceptibility Testing in Clinical Mycobacterium tuberculosis Isolates.

PMID 33972244 · 2021

associated with resistance

Mutation Information

pncA: p.G108R pncA: p.A134V pncA: p.L4S pncA: p.H51Y pncA: p.V180A pncA: p.D136Y pncA: p.G105V pncA: p.I31S pncA: p.H51D pncA: p.H51P pncA: c.A-11G

Protein Change: G108R, A134V, L4S, H51Y, V180A, D136Y, G105V, I31S, H51D, H51P
Nucleotide Change: A-11G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Sanger sequencing
Source Database: Reslit

Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.

PMID 34025934 · 2021

Mutation Information

pncA: p.D8H pncA: p.C138R pncA: p.A46V pncA: p.A46E pncA: p.A46P pncA: p.L116P pncA: p.W119G pncA: p.W119L pncA: p.L120P pncA: p.V128A pncA: p.V128G

Protein Change: D8H, C138R, A46V, A46E, A46P, L116P, W119G, W119L, L120P, V128A, V128G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: computational analysis; molecular docking and structural analysis; molecular docking and MIC testing
Source Database: Reslit

Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe(2+) Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide.

PMID 34095218 · 2021

All mutations are in the pncA gene, which encodes pyrazinamidase, and are associated with reduced PZA binding affinity and resistance.

Mutation Information

pncA: p.D49N pncA: p.Y64S pncA: p.W68G pncA: p.F94A

Protein Change: D49N, Y64S, W68G, F94A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: molecular dynamics simulations and MM-GBSA analysis
Source Database: Reslit

Genetic Diversity and Drug Susceptibility Profiles of Multidrug-Resistant Tuberculosis Strains in Southeast China.

PMID 34611415 · 2021

Mutations in pncA are associated with pyrazinamide resistance.

Mutation Information

Protein Change: E112K, Q141P, D126N, H51P, H82P, Q10P, T135P, T160A, M175V, A46E, A46V, A46T, D8N, I104S, E181K, W68R, V93G, L116P, V128G, I133T, V155G, S164P
Nucleotide Change: A152C, A246C, A29C, A403C, A478G, A523G, C137T, C421T, C42A, G136A, G22A, G311T, G541A, T202C, T278G, T347C, T383G, T398C, T464G, T490C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: mutation analysis
Source Database: Reslit

Transmission of multidrug-resistant tuberculosis in Shimen community in Shanghai, China: a molecular epidemiology study.

PMID 34715793 · 2021

Mutation Information

pncA: p.V155G pncA: p.T47P pncA: p.C14Y

Protein Change: V155G, T47P, C14Y
Confers Resistance To: pza
Validation Method: whole_genome_sequencing
Source Database: Reslit

Comparative Performance of Genomic Methods for the Detection of Pyrazinamide Resistance and Heteroresistance in Mycobacterium tuberculosis.

PMID 34757831 · 2022

Includes variants associated with resistance and susceptibility based on Köser classification

Mutation Information

pncA: p.A134V pncA: p.W68G pncA: p.Q10P / c.A29C

Protein Change: A134V, W68G, Q10P
Nucleotide Change: A29C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: TDS and MIC testing
Source Database: Reslit

The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.

PMID 34802420 · 2021

Mutation Information

pncA: p.W119R

Protein Change: W119R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and mutation analysis
Source Database: Reslit

Snapshot of Mycobacterium tuberculosis Phylogenetics from an Indian State of Arunachal Pradesh Bordering China.

PMID 35205308 · 2022

Mutation Information

pncA: p.D49A

Protein Change: D49A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: whole-genome sequencing
Source Database: Reslit

Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya.

PMID 35328028 · 2022

Mutation Information

pncA: p.Q10P pncA: p.H57D pncA: p.D63G pncA: p.K96T pncA: p.T135P

Protein Change: Q10P, H57D, D63G, K96T, T135P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

A computational perspective on the dynamic behaviour of recurrent drug resistance mutations in the pncA gene from Mycobacterium tuberculosis.

PMID 35424144 · 2021

Mutations in the pncA gene lead to reduced binding affinity of PZA to PZase, resulting in pyrazinamide resistance.

Mutation Information

pncA: p.F94L pncA: p.F94S pncA: p.K96N pncA: p.K96R pncA: p.G97C pncA: p.G97D pncA: p.G97S

Protein Change: F94L, F94S, K96N, K96R, G97C, G97D, G97S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: reduced binding affinity of PZA to PZase
Validation Method: molecular dynamics simulation and docking
Source Database: Reslit

The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China.

PMID 39745172 · 2025

Mutations in pncA were found in both PZA-resistant and PZA-sensitive isolates.

Mutation Information

Protein Change: T62A, 548fs, K45K, A440T, R212R
Nucleotide Change: A-11G, A152G, A226C, A245G, A286G, A287C, A29C, A340C, A407G, A422C, A457C, C129A, C151T, C160T, C161A, C169G, C312A, C425T, C437A, C83A, G290A, G313T, G34A, G395A, G415A, G427C, G485A, T-12C, T-7C, T104C, T14C, T20G, T269G, T347G, T355G, T416C, T416G, T56C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Sequencing and correlation with pyrazinamide resistance
Source Database: Reslit

Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006-2022.

PMID 40023848 · 2025

associated with resistance

Mutation Information

pncA: p.P54L

Protein Change: P54L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: whole-genome sequencing and phenotypic drug-susceptibility testing
Source Database: Reslit

Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.

PMID 40596923 · 2025

Scattered and diverse distribution

Mutation Information

pncA: p.W12R pncA: p.L12R

Protein Change: W12R, L12R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: targeted sequencing
Source Database: Reslit

Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong.

PMID 17360809 · 2007

Mutation Information

pncA: p.W68L

Protein Change: W68L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: PCR-SSCP/MPAC and nucleotide sequencing
Source Database: Reslit

Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.

PMID 19963078 · 2010

All mutations are missense mutations in the pncA gene associated with pyrazinamide resistance.

Mutation Information

Protein Change: L4S, G24D, D12A, D12G, C14G, Q10R, Y34D, K48T, D49N, G78C, P54L, T76P, P62L, H51R, L85P, H71Y, F94L, L116P, G105D, W119L, D136G, H137P, T135P, V7I, V7F, V139A, A134V, T142P, V155A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: loss of PZAse activity
Validation Method: analysis of clinical isolates
Source Database: Reslit

Evaluation of colorimetric methods using nicotinamide for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis.

PMID 20554826 · 2010

Mutations in the pncA gene were identified by sequencing the pncA genes from all isolates in which pyrazinamide resistance was detected by any of the three methods.

Mutation Information

pncA: p.L172P pncA: p.V139A pncA: p.F94C pncA: p.V155G pncA: p.Q10R pncA: p.T76P pncA: p.K48T pncA: p.T135P

Protein Change: L172P, V139A, F94C, V155G, Q10R, T76P, K48T, T135P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.

PMID 27459848 · 2016

most common mutation

Mutation Information

pncA: p.R140S pncA: p.A46A pncA: p.L27P pncA: p.I90S pncA: p.A92P pncA: p.T135P pncA: p.T168P

Protein Change: R140S, A46A, L27P, I90S, A92P, T135P, T168P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.

PMID 27530852 · 2016

Mutation Information

pncA: p.W119G pncA: p.M306I pncA: p.M306V pncA: p.E504D

Protein Change: W119G, M306I, M306V, E504D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing; whole-gengenome sequencing
Source Database: Reslit

Draft genome sequence of Mycobacterium tuberculosis strain B9741 of Beijing B0/W lineage from HIV positive patient from Siberia.

PMID 27761405 · 2016

Mutation Information

pncA: p.A145V

Protein Change: A145V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: SNP analysis
Source Database: Reslit

A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt.

PMID 28106529 · 2017

Mutation Information

pncA: p.A146V

Protein Change: A146V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.

PMID 28221108 · 2017

Mutations in the pncA gene are associated with pyrazinamide resistance in Mycobacterium tuberculosis.

Mutation Information

Protein Change: L151S, R154G, A102V, H71Y, S59P, G132A, G97D, E91Q, G97C, Y34D, V139G, V130A, E15G, T47I, H51P, S65S, C104R, T153H, R154W
Nucleotide Change: 312insG, 313insG, 389delT, 407insA, 408insA, 456insC, 459-467delCAGGGTGC, 515del, 515insG
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing and comparison with literature
Source Database: Reslit

Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples.

PMID 28275074 · 2017

The H57D mutation in pncA confers pyrazinamide resistance.

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium bovis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and resistance prediction
Source Database: Reslit

Revisiting the mutant prevention concentration to guide dosing in childhood tuberculosis.

PMID 28333284 · 2017

PncA mutations are associated with pyrazinamide resistance.

Mutation Information

pncA: p.A121D

Protein Change: A121D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: reported in cited literature
Source Database: Reslit

Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient.

PMID 28348821 · 2015

Mutation Information

pncA: p.I31F

Protein Change: I31F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genome sequencing and phenotypic resistance testing
Source Database: Reslit

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.

PMID 28545050 · 2017

Mutation Information

pncA: p.V154A

Protein Change: V154A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: next-generation sequencing
Source Database: Reslit

Characterization of pncA Mutations and Prediction of PZA Resistance in Mycobacterium tuberculosis Clinical Isolates From Chongqing, China.

PMID 33505367 · 2020

Mutation Information

pncA: p.S59Y pncA: p.S67W pncA: p.L76P pncA: p.G78R pncA: p.L85P pncA: p.D86G pncA: p.A92P pncA: p.V93A pncA: p.S104G pncA: p.V125A pncA: p.V130M pncA: p.G132G pncA: p.C138G pncA: p.T142R pncA: p.T167I pncA: c.403-414delACCGATCATTG pncA: c.407insTCATTGTGTGCGCCAGACGGC pncA: c.C-11T pncA: c.C-12T

Protein Change: S59Y, S67W, L76P, G78R, L85P, D86G, A92P, V93A, S104G, V125A, V130M, G132G, C138G, T142R, T167I
Nucleotide Change: 403-414delACCGATCATTG, 407insTCATTGTGTGCGCCAGACGGC, C-11T, C-12T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing and PZase activity tests; sequencing
Source Database: Reslit

Cefdinir and β-Lactamase Inhibitor Independent Efficacy Against Mycobacterium tuberculosis.

PMID 34163361 · 2021

associated with pyrazinamide resistance

Mutation Information

pncA: p.V139G

Protein Change: V139G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis.

PMID 34181476 · 2021

Mutation Information

pncA: p.L159V pncA: p.L85P pncA: p.V21G

Protein Change: L159V, L85P, V21G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and phenotypic testing
Source Database: Reslit

Performance Evaluation of GeneLEAD/Deeplex Myc-TB for Mycobacterium tuberculosis Complex Diagnosis and Drug Susceptibility Testing

PMID 34778100 · 2021

Mutation Information

pncA: p.A107G

Protein Change: A107G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic prediction and phenotypic DST correlation
Source Database: Reslit

Structural and Dynamic Insights into the W68L, L85P, and T87A Mutations of Mycobacterium tuberculosis Inducing Resistance to Pyrazinamide.

PMID 35162636 · 2022

The W68L mutation in pncA was found to reduce the binding affinity of pyrazinamide (PZA) to the enzyme, leading to resistance.

Mutation Information

pncA: p.W68L

Protein Change: W68L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: reduce the binding affinity of pyrazinamide (PZA) to the enzyme
Validation Method: molecular docking and molecular dynamics simulation
Source Database: Reslit

Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.

PMID 35442078 · 2022

Mutation Information

pncA: p.G132A pncA: p.L27P pncA: p.I5S pncA: p.T76P

Protein Change: G132A, L27P, I5S, T76P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic prediction
Source Database: Reslit

Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.

PMID 39179783 · 2024

Mutations associated with pyrazinamide resistance.

Mutation Information

pncA: p.L172P pncA: p.H57P

Protein Change: L172P, H57P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic resistance characterisation using TB-Profiler software
Source Database: Reslit

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.

PMID 39487429 · 2024

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium bovis
Confers Resistance To: pyrazinamide
Validation Method: genomic sequencing
Source Database: Reslit

Genotypes and drug resistance pattern of Mycobacterium tuberculosis complex among clinically diagnosed pulmonary tuberculosis patients.

PMID 39687724 · 2024

Mutation Information

pncA: p.V139A

Protein Change: V139A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.

PMID 39935875 · 2025

Mutation Information

pncA: p.W68R

Protein Change: W68R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022.

PMID 40207933 · 2025

Mutation Information

pncA: p.M18V pncA: p.Q10P

Protein Change: M18V, Q10P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Phylogenetically Informative Mutations in Drug Resistance Genes of Human-Infecting Mycobacterium bovis.

PMID 40303120 · 2024

associated with intrinsic PZA resistance

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium bovis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Whole-Genome Sequence-Based Diversity of Mycobacterium tuberculosis Strains Isolated from a Central Western Region of Mexico.

PMID 40559556 · 2025

Mutation Information

pncA: p.L120R

Protein Change: L120R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic resistance analysis
Source Database: Reslit

Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).

PMID 41249964 · 2025

Mutation Information

pncA: p.G10P pncA: p.R154G

Protein Change: G10P, R154G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia.

PMID 41354901 · 2025

Mutation Information

pncA: p.V180F pncA: p.D12A

Protein Change: V180F, D12A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Detection by denaturing gradient gel electrophoresis of pncA mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis isolates from the United States-Mexico border region.

PMID 15917514 · 2005

Mutations in pncA were associated with pyrazinamide resistance in Mycobacterium tuberculosis.

Mutation Information

pncA: p.Y10*pncA: p.V93L pncA: p.V180F pncA: c.T4C

Protein Change: Y10*, V93L, V180F
Nucleotide Change: T4C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DGGE and DNA sequencing
Source Database: Reslit

Detection of multidrug resistance in Mycobacterium tuberculosis.

PMID 17108078 · 2007

mutations in pncA are associated with pyrazinamide resistance

Mutation Information

pncA: p.S65S pncA: p.A3E pncA: p.Q10P pncA: p.D12A pncA: p.H51Q pncA: p.P54L pncA: p.C72W pncA: p.G132S pncA: p.I133T pncA: p.R148S pncA: p.M175V pncA: p.D53N

Protein Change: S65S, A3E, Q10P, D12A, H51Q, P54L, C72W, G132S, I133T, R148S, M175V, D53N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis.

PMID 19249243 · 2009

Mutations in pncA lead to decreased pyrazinamidase activity, contributing to pyrazinamide resistance.

Mutation Information

pncA: p.D49N pncA: p.H51R pncA: p.D12A pncA: p.D12G pncA: p.K48T pncA: p.T76P pncA: p.F94L pncA: p.T135P pncA: p.G24D pncA: p.Y34D pncA: p.G78C pncA: p.L116P

Protein Change: D49N, H51R, D12A, D12G, K48T, T76P, F94L, T135P, G24D, Y34D, G78C, L116P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: loss of activity
Validation Method: cloning and expression in E. coli
Source Database: Reslit

Molecular epidemiological study of pyrazinamide-resistance in clinical isolates of mycobacterium tuberculosis from South India.

PMID 20717529 · 2010

novel mutation

Mutation Information

pncA: p.A26G

Protein Change: A26G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: PCR-mediated DNA sequencing
Source Database: Reslit

Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis.

PMID 20879713 · 2010

H57D mutation reduces PncA activity, leading to pyrazinamide resistance in Mycobacterium bovis.

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium bovis
Confers Resistance To: pyrazinamide
Effect on Function: reduces PncA activity
Validation Method: site-directed mutagenesis and enzyme activity assays
Source Database: Reslit

Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide.

PMID 21283666 · 2011

Mutations in pncA are responsible for pyrazinamide resistance in M. tuberculosis.

Mutation Information

pncA: p.H57D pncA: p.D49G pncA: p.D8L pncA: p.D8E pncA: p.K96Q pncA: p.A134V pncA: p.C138A pncA: p.H51A pncA: p.W68L pncA: p.F13L

Protein Change: H57D, D49G, D8L, D8E, K96Q, A134V, C138A, H51A, W68L, F13L
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Confers Resistance To: pyrazinamide
Effect on Function: disrupts metal ion binding and catalytic activity; disrupts catalytic activity; disrupts substrate binding and catalytic activity
Validation Method: site-directed mutagenesis and kinetic assays
Source Database: Reslit

Rapid identification of mycobacteria and drug-resistant Mycobacterium tuberculosis by use of a single multiplex PCR and DNA sequencing.

PMID 22162548 · 2012

Mutation Information

pncA: p.H57D pncA: p.H57P pncA: p.T61P pncA: p.H82D pncA: p.C138Y

Protein Change: H57D, H57P, T61P, H82D, C138Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

FIND Tuberculosis Strain Bank: a Resource for Researchers and Developers Working on Tests To Detect Mycobacterium tuberculosis and Related Drug Resistance.

PMID 28100602 · 2017

Mutation Information

pncA: p.H51R pncA: p.Q10R

Protein Change: H51R, Q10R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Comprehensive Whole-Genome Sequencing and Reporting of Drug Resistance Profiles on Clinical Cases of Mycobacterium tuberculosis in New York State.

PMID 28381603 · 2017

Mutation Information

pncA: p.N36S pncA: p.G37R

Protein Change: N36S, G37R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: Whole-genome sequencing (WGS) and comparison with culture-based drug susceptibility testing (DST)
Source Database: Reslit

A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.

PMID 28630430 · 2017

Mutation Information

pncA: p.C14R pncA: p.C14*

Protein Change: C14R, C14*
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and enzymatic activity testing (Wayne's assay)
Source Database: Reslit

Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing.

PMID 33361124 · 2020

Mutation Information

pncA: p.L85R

Protein Change: L85R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: whole_genome_sequencing
Source Database: Reslit

In-host population dynamics of Mycobacterium tuberculosis complex during active disease.

PMID 33522489 · 2021

Mutation Information

pncA: p.G139D

Protein Change: G139D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and analysis of allele frequency changes
Source Database: Reslit

Genome analyses of 174 strains of Mycobacterium tuberculosis provide insight into the evolution of drug resistance and reveal potential drug targets.

PMID 33750515 · 2021

Mutation Information

pncA: p.A3P pncA: p.I6T pncA: p.D12A pncA: p.D12G pncA: p.D49N pncA: p.H51Q pncA: p.H57D pncA: p.W68R pncA: p.L85P pncA: p.L85R pncA: p.T114M pncA: p.T142M pncA: p.A171V pncA: p.L182S

Protein Change: A3P, I6T, D12A, D12G, D49N, H51Q, H57D, W68R, L85P, L85R, T114M, T142M, A171V, L182S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequence analysis
Source Database: Reslit

Whole genome sequencing of clinical samples reveals extensively drug resistant tuberculosis (XDR TB) strains from the Beijing lineage in Nigeria, West Africa.

PMID 34462504 · 2021

Mutation Information

pncA: p.D12G

Protein Change: D12G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.

PMID 35524232 · 2022

associated with Pyrazinamide resistance

Mutation Information

pncA: p.Q10P pncA: p.I31T

Protein Change: Q10P, I31T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic and phenotypic correlation
Source Database: Reslit

Tracking the evolution of an extensively drug-resistant cross-border Mycobacterium tuberculosis cluster, Europe, January 2016 up to August 2025: implications for European surveillance.

PMID 41267660 · 2025

Mutation Information

pncA: p.A146V

Protein Change: A146V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis
Source Database: Reslit

Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.

PMID 25186134 · 2014

mutations in pncA are associated with pyrazinamide resistance

Mutation Information

pncA: p.L10R

Protein Change: L10R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing and MIC testing
Source Database: Reslit

Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.

PMID 25407810 · 2014

Mutation in pncA is associated with pyrazinamide resistance.

Mutation Information

pncA: p.V125G

Protein Change: V125G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis
Source Database: Reslit

Added value of whole-genome sequencing for management of highly drug-resistant TB.

PMID 25492392 · 2015

Strong evidence for a causal association with a drug-resistant phenotype

Mutation Information

pncA: p.T160M pncA: p.T167A

Protein Change: T160M, T167A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria.

PMID 25559874 · 2014

Mutation Information

pncA: p.W68L pncA: p.H51P

Protein Change: W68L, H51P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: literature
Source Database: Reslit

Phenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Zhejiang, China.

PMID 25583712 · 2015

Mutation Information

Protein Change: I5S, I6T, V7F, V7G, D8G, Q10P, D12A, C14W, G17D, L19R, T47A, T47P, D49A, P54Q, H57P, P62T, W68R, H71R, T76P, T76I, K96T, S104R, G108R, D110G, T114P, L116R, G132C, G132D, A134V, T135P, H137R, V139M, V139A, Q141P, T142A, T142K, A146T, V157G, M175T, V180F, L182W
Nucleotide Change: T-12C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.

PMID 25673793 · 2015

Mutation Information

pncA: p.G132D pncA: p.H57R pncA: c.GAA->TGA

Protein Change: G132D, H57R
Nucleotide Change: GAA->TGA
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Mechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosis pyrazinamidase enzyme and pyrazinamide susceptibility.

PMID 25708048 · 2015

The K96R mutation in the pncA gene was found to confer resistance to pyrazinamide by increasing the volume of the binding cavity, reducing the stability of PZA binding.

Mutation Information

pncA: p.K96R

Protein Change: K96R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: molecular dynamics simulations, docking studies
Source Database: Reslit

Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis.

PMID 25765106 · 2015

Mutation Information

pncA: p.C14G pncA: p.S59F pncA: p.F81S pncA: p.H82Y pncA: p.Y103C pncA: p.A143T

Protein Change: C14G, S59F, F81S, H82Y, Y103C, A143T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Source Database: Reslit

Mutations conferring resistance to first- and second-line drugs in multidrug-resistant Mycobacterium tuberculosis clinical isolates in southeast Mexico.

PMID 25819011 · 2015

Mutation Information

pncA: p.L120P pncA: p.S95T

Protein Change: L120P, S95T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.

PMID 25953188 · 2015

associated with pyrazinamide resistance

Mutation Information

pncA: p.A106V

Protein Change: A106V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis
Source Database: Reslit

Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.

PMID 26116186 · 2015

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and phenotypic drug-susceptibility testing
Source Database: Reslit

Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.

PMID 31243306 · 2019

Confirmed in the study

Mutation Information

pncA: p.D12A pncA: p.G24D pncA: p.I133T

Protein Change: D12A, G24D, I133T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

Retrospective Analysis of Archived Pyrazinamide Resistant Mycobacterium tuberculosis Complex Isolates from Uganda-Evidence of Interspecies Transmission.

PMID 31362370 · 2019

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis
Source Database: Reslit

Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan.

PMID 31628383 · 2019

Mutation Information

pncA: p.V180F pncA: p.H71R

Protein Change: V180F, H71R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.

PMID 31910804 · 2020

Mutation Information

pncA: p.D49G pncA: p.H57D pncA: p.H57R pncA: p.W68R pncA: p.T76P pncA: p.G97D pncA: p.Q10P pncA: p.D12A pncA: p.C14R pncA: p.V139L

Protein Change: D49G, H57D, H57R, W68R, T76P, G97D, Q10P, D12A, C14R, V139L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic variant analysis
Source Database: Reslit

Tuberculosis in Liberia: high multidrug-resistance burden, transmission and diversity modelled by multiple importation events.

PMID 31935183 · 2020

Mutation Information

pncA: p.R154G pncA: p.H43Y pncA: p.E15*pncA: p.C14G pncA: p.N11S

Protein Change: R154G, H43Y, E15*, C14G, N11S
Confers Resistance To: pza
Validation Method: phenotypic DST
Source Database: Reslit

Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.

PMID 31971587 · 2020

The G78V mutation in pncA was found in TCDC4 and TCDC10, and the V139A mutation was found in TCDC11.

Mutation Information

pncA: p.G78V pncA: p.V139A

Protein Change: G78V, V139A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: experimental assay; functional assays
Source Database: Reslit

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic.

PMID 32014024 · 2020

Mutation Information

pncA: p.A36T

Protein Change: A36T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: MIC testing
Source Database: Reslit

Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance.

PMID 38248866 · 2024

Mutation Information

pncA: p.V115A

Protein Change: V115A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: reported in cited literature
Source Database: Reslit

Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.

PMID 38772358 · 2024

Mutation Information

pncA: p.A134T

Protein Change: A134T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Sanger sequencing
Source Database: Reslit

Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.

PMID 24733464 · 2014

Mutation Information

pncA: p.Q96P

Protein Change: Q96P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.

PMID 29906261 · 2018

Mutation Information

pncA: p.Y103D

Protein Change: Y103D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

Protein Change: A172G, A146E, A146V, C138R, C14R, D12A, D136Y, D136fs, D49G, D49N, D63G, D8E, D8H, D8N, F58S, G108Ter, G97S, H51R, H57D, H57R, H71R, H82R, I133T, I5T, I6T, L116R, L117fs, L151S, L182S, L4S, L85R, M175V, P54L, P62S, P69R, Q10P, Q10R, Q141P, S164Ter, S67P, T100P, T114fs, T135P, T76P, V128G, V131fs, V139G, V180A, V180F, V180G, V7G, W68G, W68R, Y103Ter, Y34D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant; frameshift mutation; nonsense mutation
Validation Method: variant calling and annotation
Source Database: ReslitCard Database

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.

PMID 30373719 · 2018

Mutation Information

pncA: p.Q10P pncA: p.I133T

Protein Change: Q10P, I133T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic and phenotypic analysis
Source Database: Reslit

Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.

PMID 30789128 · 2019

Mutation Information

pncA: p.Q10H pncA: p.L4W pncA: p.C14*

Protein Change: Q10H, L4W, C14*
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

Overcoming the pitfalls of automatic interpretation of whole genome sequencing data by online tools for the prediction of pyrazinamide resistance in Mycobacterium tuberculosis.

PMID 30817803 · 2019

Mutations in pncA were associated with pyrazinamide resistance.

Mutation Information

pncA: p.K96Q pncA: p.D63G pncA: p.G78S pncA: p.L182S pncA: p.K96N pncA: p.M175I pncA: p.L4S pncA: p.G97D pncA: p.S67*pncA: p.V44A pncA: p.V180F

Protein Change: K96Q, D63G, G78S, L182S, K96N, M175I, L4S, G97D, S67*, V44A, V180F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Sanger sequencing
Source Database: Reslit

Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis.

PMID 30833432 · 2019

Mutation Information

pncA: p.A146V

Protein Change: A146V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: whole-genome sequencing
Source Database: Reslit

Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting.

PMID 30944370 · 2019

Most frequent mutation

Mutation Information

pncA: p.Q10R

Protein Change: Q10R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genetic distance and phylogenetic analysis
Source Database: Reslit

Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture.

PMID 31109296 · 2019

Mutation Information

pncA: p.Q122H

Protein Change: Q122H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic DST
Source Database: Reslit

Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.

PMID 36467663 · 2022

associated with pyrazinamide resistance

Mutation Information

pncA: p.H57D pncA: p.R106H

Protein Change: H57D, R106H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis; genomic sequencing
Source Database: Reslit

Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001.

PMID 36683685 · 2022

mutation in pncA confers resistance to pyrazinamide

Mutation Information

pncA: p.L910P

Protein Change: L910P
Organisms: Mycobacterium fortuitum
Confers Resistance To: pyrazinamide
Source Database: Reslit

Quantitative (1)H Nuclear Magnetic Resonance Assay for the Rapid Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis from Sputum Samples.

PMID 37071032 · 2023

The T135P mutation in pncA was experimentally validated to confer PZA resistance.

Mutation Information

pncA: p.T135P

Protein Change: T135P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: decreased ability to hydrolyze PZA
Validation Method: NMR-based PZA hydrolysis assay and pncA sequencing
Source Database: Reslit

Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study.

PMID 37147590 · 2023

Mutations in pncA are associated with pyrazinamide resistance.

Mutation Information

pncA: p.I133T

Protein Change: I133T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis
Source Database: Reslit

100

Rapid Identification of Lineage and Drug Resistance in Clinical Samples of Mycobacterium tuberculosis.

PMID 37374968 · 2023

Mutations in pncA were found in pyrazinamide-resistant strains, but some were not described as conferring resistance.

Mutation Information

pncA: p.G17S pncA: p.K48N

Protein Change: G17S, K48N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis
Source Database: Reslit

101

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants.

PMID 37750734 · 2023

Detected in 65/1831 strains

Mutation Information

pncA: p.G97C pncA: p.V180G pncA: p.A146T

Protein Change: G97C, V180G, A146T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: LoFreq and manual review
Source Database: Reslit

102

Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis.

PMID 37816829 · 2023

Mutation Information

pncA: p.T160A pncA: p.T100I pncA: p.M306I

Protein Change: T160A, T100I, M306I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic resistance prediction using TB-Profiler software
Source Database: Reslit

103

Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.

PMID 37883448 · 2023

Mutation Information

pncA: p.Y99fs pncA: p.N149fs pncA: p.R154M pncA: p.L172fs

Protein Change: Y99fs, N149fs, R154M, L172fs
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

104

The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.

PMID 38019772 · 2023

Mutation Information

pncA: p.H57P

Protein Change: H57P
Confers Resistance To: pza
Validation Method: variant calling and resistance annotation
Source Database: Reslit

105

A preliminary evaluation of targeted nanopore sequencing technology for the detection of Mycobacterium tuberculosis in bronchoalveolar lavage fluid specimens.

PMID 38029234 · 2023

Mutation Information

pncA: p.D63G pncA: p.T76I

Protein Change: D63G, T76I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: targeted nanopore sequencing
Source Database: Reslit

106

Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.

PMID 38048599 · 2024

Mutation Information

pncA: p.T135P pncA: p.C14R pncA: p.L27P pncA: p.V130G pncA: p.V139G pncA: p.Y34D

Protein Change: T135P, C14R, L27P, V130G, V139G, Y34D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

107

A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.

PMID 38051742 · 2023

Mutation Information

pncA: p.H82R pncA: p.V125F pncA: p.H51R pncA: p.G108E pncA: p.D8H pncA: p.H43P pncA: p.A46V pncA: p.D49A pncA: p.P69L pncA: p.S104G pncA: p.H137Y pncA: p.M175I pncA: c.A10G

Protein Change: H82R, V125F, H51R, G108E, D8H, H43P, A46V, D49A, P69L, S104G, H137Y, M175I
Nucleotide Change: A10G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

108

Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.

PMID 38061383 · 2024

mutations in pncA are associated with pyrazinamide resistance

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic_prediction_and_phenotypic_testing
Source Database: Reslit

109

Emergence and spread of extensively and totally drug-resistant tuberculosis, South Africa.

PMID 23622714 · 2013

Mutation Information

pncA: p.G172R

Protein Change: G172R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

110

Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.

PMID 24047678 · 2013

Excluding 25 silent pncA mutations (Ser32Ser most common, n = 14). Mutations in pncA not previously reported.

Mutation Information

pncA: p.G113F pncA: p.L19R pncA: p.R121L pncA: p.Q10P pncA: p.V7G pncA: p.A161P pncA: p.H137D pncA: p.480fs pncA: p.409fs / c.C409G

Protein Change: G113F, L19R, R121L, Q10P, V7G, A161P, H137D, 480fs, 409fs
Nucleotide Change: C409G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

111

Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.

PMID 24073633 · 2014

Case 1

Mutation Information

pncA: p.K96R

Protein Change: K96R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Ion Torrent sequencing and phenotypic DST
Source Database: Reslit

112

A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance.

PMID 29020922 · 2017

Mutations in pncA are associated with pyrazinamide resistance.

Mutation Information

pncA: p.D12A pncA: p.T135P pncA: p.D49N pncA: p.D12G pncA: p.Y34D pncA: p.H51R pncA: p.H57R pncA: p.P62L pncA: p.Y64D pncA: p.F94L pncA: p.V131G pncA: p.V139A pncA: p.L182W

Protein Change: D12A, T135P, D49N, D12G, Y34D, H51R, H57R, P62L, Y64D, F94L, V131G, V139A, L182W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis and mutation association
Source Database: Reslit

113

Culture and Next-generation sequencing-based drug susceptibility testing unveil high levels of drug-resistant-TB in Djibouti: results from the first national survey.

PMID 29247181 · 2017

Mutation Information

pncA: p.S450L pncA: p.M117T

Protein Change: S450L, M117T
Organisms: Mycobacterium tuberculosis, Mycobacterium canettii
Confers Resistance To: pyrazinamide
Validation Method: genotypic drug susceptibility testing; whole genome sequencing
Source Database: Reslit

114

Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.

PMID 29310751 · 2018

Mutations promoted from gene entry 'pncA' (model emitted mutations_found inside genes).

Mutation Information

pncA: p.W68R pncA: p.T135P pncA: p.Q10P pncA: p.D12E

Protein Change: W68R, T135P, Q10P, D12E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

115

Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.

PMID 29460750 · 2018

Mutation Information

pncA: p.L159R pncA: p.C138R pncA: p.T135P pncA: p.V130E pncA: p.Q122*pncA: p.Y103*pncA: p.G97S

Protein Change: L159R, C138R, T135P, V130E, Q122*, Y103*, G97S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

116

Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.

PMID 29514936 · 2018

Mutation Information

pncA: p.T100I pncA: p.T159A pncA: p.A134R pncA: p.V163A pncA: p.T153I pncA: p.F106S pncA: c.G21del

Protein Change: T100I, T159A, A134R, V163A, T153I, F106S
Nucleotide Change: G21del
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

117

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.

PMID 29755957 · 2018

G171A mutation leads to reduced pyrazinamidase activity.

Mutation Information

pncA: p.G171A

Protein Change: G171A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: experimental validation
Source Database: Reslit

118

Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.

PMID 29779775 · 2018

Most common mutation related to pyrazinamide resistance in Mozambican isolates

Mutation Information

pncA: p.K19R

Protein Change: K19R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

119

Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.

PMID 29848567 · 2018

Mutation Information

pncA: p.L4S

Protein Change: L4S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

120

Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.

PMID 32063558 · 2020

Mutation Information

pncA: p.L19R pncA: p.R154G

Protein Change: L19R, R154G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

121

Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan

PMID 32091355 · 2020

Mutation Information

pncA: p.Q10R

Protein Change: Q10R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

122

Direct Determination of Pyrazinamide (PZA) Susceptibility by Sputum Microscopic Observation Drug Susceptibility (MODS) Culture at Neutral pH: the MODS-PZA Assay.

PMID 32132191 · 2020

Mutations in pncA are associated with PZA resistance.

Mutation Information

pncA: p.Q10R pncA: p.H51R pncA: p.K48T pncA: p.F81S pncA: p.P62S pncA: p.Q10P pncA: p.H71R

Protein Change: Q10R, H51R, K48T, F81S, P62S, Q10P, H71R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: resistant; susceptible
Validation Method: pncA sequencing
Source Database: Reslit

123

Artificial Intelligence and Machine learning based prediction of resistant and susceptible mutations in Mycobacterium tuberculosis.

PMID 32218465 · 2020

Mutation Information

pncA: p.C96E pncA: p.V155M

Protein Change: C96E, V155M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: machine learning prediction
Source Database: Reslit

124

Gibbs Free Energy Calculation of Mutation in PncA and RpsA Associated With Pyrazinamide Resistance.

PMID 32328498 · 2020

Mutation Information

pncA: p.N11K pncA: p.P69T pncA: p.D126N pncA: p.L19R pncA: p.R140H pncA: p.E144K

Protein Change: N11K, P69T, D126N, L19R, R140H, E144K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: molecular dynamics simulation and Gibbs free energy calculation
Source Database: Reslit

125

Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.

PMID 32384098 · 2020

Mutations in pncA are associated with pyrazinamide resistance.

Mutation Information

pncA: p.L4S pncA: p.D12A pncA: p.F13L pncA: p.L35R pncA: p.A46V pncA: p.H51Y pncA: p.D63G pncA: p.W68R pncA: p.G108R

Protein Change: L4S, D12A, F13L, L35R, A46V, H51Y, D63G, W68R, G108R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: high-throughput sequencing
Source Database: Reslit

126

Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.

PMID 32538300 · 2020

Present in GC1 isolates.

Mutation Information

pncA: p.D63A

Protein Change: D63A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamidepza
Validation Method: whole genome sequencing
Source Database: Reslit

127

Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.

PMID 32782426 · 2020

Mutation Information

pncA: p.S59F

Protein Change: S59F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: association testing
Source Database: Reslit

128

A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis.

PMID 35780211 · 2022

Mutation Information

pncA: p.G78D pncA: p.T100I pncA: p.R140G

Protein Change: G78D, T100I, R140G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DeepLIFT saliency analysis and in silico introduction of mutations
Source Database: Reslit

129

Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.

PMID 35907429 · 2022

Mutation associated with pyrazinamide resistance.

Mutation Information

pncA: p.L19P pncA: p.D63A pncA: p.V7A pncA: p.V180A

Protein Change: L19P, D63A, V7A, V180A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic resistance prediction based on mutation catalogue
Source Database: Reslit

130

Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.

PMID 35930613 · 2022

Associated with resistance

Mutation Information

pncA: p.A102V

Protein Change: A102V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Sanger sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

131

Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.

PMID 35931954 · 2022

Mutation Information

pncA: p.A30V pncA: p.L172P pncA: p.F106L pncA: p.T160A

Protein Change: A30V, L172P, F106L, T160A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: genomic sequencing
Source Database: Reslit

132

High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.

PMID 35989319 · 2022

Mutation in pncA is associated with pyrazinamide resistance.

Mutation Information

pncA: p.G171A

Protein Change: G171A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic analysis
Source Database: Reslit

133

Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.

PMID 36102651 · 2022

Mutation Information

pncA: p.H57D

Protein Change: H57D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: targeted sequencing
Source Database: Reslit

134

Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance.

PMID 36135195 · 2022

Mutation Information

pncA: p.L182S pncA: p.L4S pncA: p.H57D

Protein Change: L182S, L4S, H57D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

135

Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update.

PMID 36209317 · 2022

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.D63H pncA: p.C138S pncA: p.Q141P

Protein Change: D63H, C138S, Q141P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Validation Method: reported in cited literature
Source Database: ReslitCard Database

136

Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.

PMID 38892433 · 2024

Mutation Information

pncA: p.H57D pncA: p.P69Q pncA: p.I49V pncA: p.Q10K pncA: p.R140S pncA: p.D136N pncA: p.H51Y pncA: p.L182S pncA: c.386_394del pncA: c.446_453del pncA: c.A-11C

Protein Change: H57D, P69Q, I49V, Q10K, R140S, D136N, H51Y, L182S
Nucleotide Change: 386_394del, 446_453del, A-11C
Organisms: Mycobacterium bovis, Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: WGS-based AMR prediction and phenotypic DST
Source Database: Reslit

137

Applying whole genome sequencing to predict phenotypic drug resistance in Mycobacterium tuberculosis: leveraging 20 years of nationwide data from Denmark.

PMID 38904390 · 2024

Mutation Information

pncA: p.L4S pncA: p.H57D / c.C170G pncA: p.P69L / c.C205T pncA: p.F94C / c.T280G

Protein Change: L4S, H57D, P69L, F94C
Nucleotide Change: C170G, C205T, T280G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic resistance prediction
Source Database: Reslit

138

Targeted next-generation sequencing of Mycobacterium tuberculosis from patient samples: lessons learned from high drug-resistant burden clinical settings in Bangladesh.

PMID 39136526 · 2024

Mutation Information

pncA: p.A46V

Protein Change: A46V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: tNGS and pDST
Source Database: Reslit

139

PMID 978-92-4-008241-0

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.I31S pncA: p.Y34D pncA: p.Y34Ter pncA: p.Y34S pncA: p.L35P pncA: p.Y41Ter pncA: p.H43P pncA: p.V44G pncA: p.A46V pncA: p.A46E pncA: p.T47A pncA: p.T47P pncA: p.K48E pncA: p.K48T pncA: p.D49E pncA: p.D49A pncA: p.D49N pncA: p.D49G pncA: p.H51Q pncA: p.H51Y pncA: p.H51P pncA: p.H51D pncA: p.H51R pncA: p.P54T pncA: p.P54S pncA: p.P54Q pncA: p.P54L pncA: p.P54R pncA: p.H57D pncA: p.H57Y pncA: p.H57L pncA: p.H57R pncA: p.H57Q pncA: p.F58L pncA: p.F58S pncA: p.F58C pncA: p.S59P pncA: p.T61P pncA: p.P62L pncA: p.P62T pncA: p.P62S pncA: p.P62R pncA: p.D63G pncA: p.D63A pncA: p.Y64D pncA: p.Y64Ter pncA: p.S66Ter pncA: p.S66P pncA: p.S67Ter pncA: p.S67P pncA: p.W68R pncA: p.W68Ter pncA: p.W68G pncA: p.W68L pncA: p.W68C pncA: p.P69L pncA: p.H71Y pncA: p.H71R pncA: p.H71P pncA: p.C72Y pncA: p.C72R pncA: p.T76P pncA: p.T76I pncA: p.G78V pncA: p.G78D pncA: p.G78S pncA: p.H82R pncA: p.A3E pncA: p.L4W pncA: p.L4S pncA: p.I5S pncA: p.I6T pncA: p.V7L pncA: p.V7F pncA: p.V7A pncA: p.V7G pncA: p.D8Y pncA: p.D8A pncA: p.D8N pncA: p.D8G pncA: p.D8H pncA: p.D8E pncA: p.V9G pncA: p.Q10Ter pncA: p.Q10P pncA: p.Q10R pncA: p.Q10H pncA: p.D12N pncA: p.D12A pncA: p.D12E pncA: p.D12G pncA: p.F13I pncA: p.F13S pncA: p.F13L pncA: p.C14R pncA: p.C14W pncA: p.C14Ter pncA: p.E15Ter pncA: p.G17D pncA: p.S18Ter pncA: p.L19P pncA: p.V21G pncA: p.G24D pncA: p.L27P pncA: p.I31T pncA: p.E144Ter pncA: p.A146E pncA: p.A146V pncA: p.A146T pncA: p.L151S pncA: p.R154M pncA: p.R154G pncA: p.V155M pncA: p.V155A pncA: p.V155G pncA: p.L159P pncA: p.L159R pncA: p.L159V pncA: p.T160K pncA: p.T160P pncA: p.G162D pncA: p.V163A pncA: p.S164Ter pncA: p.S164P pncA: p.T168P pncA: p.A171E pncA: p.A171P pncA: p.L172P pncA: p.E173Ter pncA: p.E174Ter pncA: p.M175V pncA: p.M175R pncA: p.M175I pncA: p.M175T pncA: p.T177P pncA: p.V180F pncA: p.V180A pncA: p.V180G pncA: p.E181Ter pncA: p.L182W pncA: p.L182S pncA: p.M1Var pncA: p.H71D pncA: p.L85P pncA: p.L85R pncA: p.I90T pncA: p.I90N pncA: p.I90S pncA: p.E91Ter pncA: p.V93A pncA: p.V93L pncA: p.F94C pncA: p.F94S pncA: p.F94L pncA: p.Y95Ter pncA: p.Y95D pncA: p.K96N pncA: p.K96T pncA: p.K96R pncA: p.K96E pncA: p.K96Q pncA: p.G97C pncA: p.G97V pncA: p.G97D pncA: p.G97S pncA: p.G97R pncA: p.Y99Ter pncA: p.T100P pncA: p.G101Ter pncA: p.A102P pncA: p.A102T pncA: p.Y103D pncA: p.Y103H pncA: p.Y103Ter pncA: p.Y103C pncA: p.S104R pncA: p.S104I pncA: p.S104G pncA: p.G105D pncA: p.G105V pncA: p.F106L pncA: p.F106S pncA: p.E107Ter pncA: p.G108E pncA: p.G108R pncA: p.E111Ter pncA: p.T114P pncA: p.L116P pncA: p.L116R pncA: p.W119C pncA: p.W119G pncA: p.W119R pncA: p.W119L pncA: p.W119Ter pncA: p.L120Q pncA: p.L120P pncA: p.L120R pncA: p.R121P pncA: p.Q122Ter pncA: p.V125G pncA: p.V125F pncA: p.V128G pncA: p.D129N pncA: p.V130M pncA: p.V130G pncA: p.V131F pncA: p.V131G pncA: p.G132C pncA: p.G132S pncA: p.G132D pncA: p.G132A pncA: p.I133T pncA: p.A134V pncA: p.T135N pncA: p.T135P pncA: p.D136G pncA: p.D136V pncA: p.H137P pncA: p.C138R pncA: p.V139M pncA: p.V139A pncA: p.V139G pncA: p.V139L pncA: p.R140P pncA: p.Q141Ter pncA: p.Q141P pncA: p.T142M pncA: p.T142P pncA: p.T142K pncA: p.T142A pncA: p.A143G

Protein Change: I31S, Y34D, Y34Ter, Y34S, L35P, Y41Ter, H43P, V44G, A46V, A46E, T47A, T47P, K48E, K48T, D49E, D49A, D49N, D49G, H51Q, H51Y, H51P, H51D, H51R, P54T, P54S, P54Q, P54L, P54R, H57D, H57Y, H57L, H57R, H57Q, F58L, F58S, F58C, S59P, T61P, P62L, P62T, P62S, P62R, D63G, D63A, Y64D, Y64Ter, S66Ter, S66P, S67Ter, S67P, W68R, W68Ter, W68G, W68L, W68C, P69L, H71Y, H71R, H71P, C72Y, C72R, T76P, T76I, G78V, G78D, G78S, H82R, A3E, L4W, L4S, I5S, I6T, V7L, V7F, V7A, V7G, D8Y, D8A, D8N, D8G, D8H, D8E, V9G, Q10Ter, Q10P, Q10R, Q10H, D12N, D12A, D12E, D12G, F13I, F13S, F13L, C14R, C14W, C14Ter, E15Ter, G17D, S18Ter, L19P, V21G, G24D, L27P, I31T, E144Ter, A146E, A146V, A146T, L151S, R154M, R154G, V155M, V155A, V155G, L159P, L159R, L159V, T160K, T160P, G162D, V163A, S164Ter, S164P, T168P, A171E, A171P, L172P, E173Ter, E174Ter, M175V, M175R, M175I, M175T, T177P, V180F, V180A, V180G, E181Ter, L182W, L182S, M1Var, H71D, L85P, L85R, I90T, I90N, I90S, E91Ter, V93A, V93L, F94C, F94S, F94L, Y95Ter, Y95D, K96N, K96T, K96R, K96E, K96Q, G97C, G97V, G97D, G97S, G97R, Y99Ter, T100P, G101Ter, A102P, A102T, Y103D, Y103H, Y103Ter, Y103C, S104R, S104I, S104G, G105D, G105V, F106L, F106S, E107Ter, G108E, G108R, E111Ter, T114P, L116P, L116R, W119C, W119G, W119R, W119L, W119Ter, L120Q, L120P, L120R, R121P, Q122Ter, V125G, V125F, V128G, D129N, V130M, V130G, V131F, V131G, G132C, G132S, G132D, G132A, I133T, A134V, T135N, T135P, D136G, D136V, H137P, C138R, V139M, V139A, V139G, V139L, R140P, Q141Ter, Q141P, T142M, T142P, T142K, T142A, A143G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant; nonsense mutation
Source Database: Card Database

140

Molecular characterization of pncA gene mutations in Mycobacterium tuberculosis clinical isolates from China.

PMID 10813147 · 2000

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.S88Ter pncA: p.T47P pncA: p.N118T pncA: p.Y41H

Protein Change: S88Ter, T47P, N118T, Y41H
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: nonsense mutation; single resistance variant
Source Database: Card Database

141

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis.

PMID 9055989 · 1997

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.C72R pncA: p.V139L pncA: p.K96N pncA: p.C138Y pncA: p.D12A pncA: p.T142K pncA: p.G132S pncA: p.H51Q pncA: p.T142M pncA: p.I5S pncA: p.A26G pncA: p.P69R pncA: p.A171P pncA: p.D12N

Protein Change: C72R, V139L, K96N, C138Y, D12A, T142K, G132S, H51Q, T142M, I5S, A26G, P69R, A171P, D12N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

142

Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms.

PMID 9056006 · 1997

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.L85P pncA: p.Y41Ter pncA: p.V139A pncA: p.L19P pncA: p.R121P pncA: p.T47A pncA: p.P54T pncA: p.T76P pncA: p.H57D pncA: p.F94P pncA: p.W119R pncA: p.H137R pncA: p.W68L

Protein Change: L85P, Y41Ter, V139A, L19P, R121P, T47A, P54T, T76P, H57D, F94P, W119R, H137R, W68L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant; nonsense mutation
Source Database: Card Database

143

Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Korea.

PMID 11641519 · 2001

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

Protein Change: V155G, V139M, L85R, A46E, Q10R, D136Y, V180F, Q10P, D8G, L172P, Y64D, Y103H, L159R, A146T, Q141Ter, D136N, T135P, W119Ter, Y103S, K96Q, G78D, T76I, W68Ter, W68S, W68G, W68R, S67P, F58L, D49A, V45G, A25E, A26G, A28D, G23V, C14Y, C14R, Y99D, V9G, V7F, V7D, L4W, M1S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant; nonsense mutation; multiple resistance variants
Source Database: Card Database

144

pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia.

PMID 10390239 · 1999

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.Q141P pncA: p.I133T pncA: p.V7G pncA: p.Y103Ter pncA: p.K96E pncA: p.Q10Ter pncA: p.A161P pncA: p.T160P pncA: p.R154G pncA: p.V125D pncA: p.L116R pncA: p.A102V pncA: p.A102T pncA: p.S66P pncA: p.D49V pncA: p.T47S pncA: p.Q10K pncA: p.D8Y

Protein Change: Q141P, I133T, V7G, Y103Ter, K96E, Q10Ter, A161P, T160P, R154G, V125D, L116R, A102V, A102T, S66P, D49V, T47S, Q10K, D8Y
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant; nonsense mutation
Source Database: Card Database

145

Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant mycobacterium tuberculosis strains.

PMID 17596354 · 2007

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.M175V pncA: p.C72W pncA: p.P54L pncA: p.L27P pncA: p.A3E

Protein Change: M175V, C72W, P54L, L27P, A3E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

146

Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China.

PMID 31910878 · 2020

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.L182S pncA: p.E174G pncA: p.A161G pncA: p.V157G pncA: p.T100P pncA: p.R140G pncA: p.C138W pncA: p.K96M pncA: p.S164P pncA: p.H57Q pncA: p.D63Y pncA: p.T142K pncA: p.G17S pncA: p.V9A pncA: p.Q122Ter pncA: p.R154W

Protein Change: L182S, E174G, A161G, V157G, T100P, R140G, C138W, K96M, S164P, H57Q, D63Y, T142K, G17S, V9A, Q122Ter, R154W
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant; multiple resistance variants; nonsense mutation
Source Database: Card Database

147

Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.

PMID 21300839 · 2011

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.D12E

Protein Change: D12E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

148

Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study.

PMID 25336456 · 2014

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.Y99Ter pncA: p.W68C

Protein Change: Y99Ter, W68C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: nonsense mutation; single resistance variant
Source Database: Card Database

149

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.

PMID 35944069 · 2022

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.A134V pncA: p.A146E pncA: p.A146V pncA: p.A161P pncA: p.A171T pncA: p.A3E pncA: p.A46E pncA: p.A46V pncA: p.C138R pncA: p.C138S pncA: p.C138Y pncA: p.C14R pncA: p.C14Y pncA: p.C72R pncA: p.C72W pncA: p.D12A pncA: p.D12E pncA: p.D12N pncA: p.D136H pncA: p.D136N pncA: p.D136Y pncA: p.D49G pncA: p.D49N pncA: p.D49V pncA: p.D63G pncA: p.D63H pncA: p.D8E pncA: p.D8G pncA: p.D8H pncA: p.D8N pncA: p.D8Y pncA: p.E174G pncA: p.F58L pncA: p.F58S pncA: p.G108Ter pncA: p.G132S pncA: p.G17D pncA: p.G23V pncA: p.G78D pncA: p.G97S pncA: p.H137P pncA: p.H137R pncA: p.H51Q pncA: p.H51R pncA: p.H51Y pncA: p.H57D pncA: p.H57Q pncA: p.H57R pncA: p.H71R pncA: p.H82R pncA: p.I133T pncA: p.I5T pncA: p.I6T pncA: p.K96E pncA: p.K96M pncA: p.K96N pncA: p.K96Q pncA: p.L116R pncA: p.L151S pncA: p.L172P pncA: p.L19P pncA: p.L27P pncA: p.L4S pncA: p.L4W pncA: p.L85P pncA: p.L85R pncA: p.M175V pncA: p.P54L pncA: p.P54T pncA: p.P62S pncA: p.Q10P pncA: p.Q10R pncA: p.Q141P pncA: p.S104C pncA: p.S164Ter pncA: p.S164P pncA: p.S66P pncA: p.S67P pncA: p.T135P pncA: p.T142K pncA: p.T142M pncA: p.T160P pncA: p.T47A pncA: p.T47S pncA: p.T76I pncA: p.T76P pncA: p.V125D pncA: p.V128G pncA: p.V139A pncA: p.V139G pncA: p.V139L pncA: p.V139M pncA: p.V155G pncA: p.V180F pncA: p.V180G pncA: p.V7D pncA: p.V7F pncA: p.V7G pncA: p.W119R pncA: p.W68C pncA: p.W68G pncA: p.W68L pncA: p.W68R pncA: p.Y103Ter pncA: p.Y103H pncA: p.Y34D pncA: p.Y41H pncA: p.F81V pncA: p.G78C pncA: p.G97R pncA: p.K48E pncA: p.L159V pncA: p.A171E pncA: p.P54Q pncA: p.D12G pncA: p.Q141Ter pncA: p.S104G pncA: p.S32I pncA: p.F94L pncA: p.F94S pncA: p.G108R pncA: p.G132A pncA: p.G132D pncA: p.G162D pncA: p.G24D pncA: p.G97C pncA: p.G97D pncA: p.T114P pncA: p.H57P pncA: p.H57Y pncA: p.H71D pncA: p.H71Q pncA: p.H71Y pncA: p.K96R pncA: p.K96T pncA: p.L116P pncA: p.L120P pncA: p.L159P pncA: p.M175I pncA: p.M175T pncA: p.V21G pncA: p.P54S pncA: p.P62L pncA: p.P62Q pncA: p.V7L pncA: p.Y99Ter pncA: p.R123P pncA: p.S104R pncA: p.S59P pncA: p.T135N pncA: p.T142A pncA: p.T168P pncA: p.V125F pncA: p.V125G pncA: p.E37Ter pncA: p.E91Ter pncA: p.F106S pncA: p.F106Y pncA: p.F13I pncA: p.F13V pncA: p.F13Y pncA: p.F58I pncA: p.F81S pncA: p.F94C pncA: p.G101Ter pncA: p.G101E pncA: p.G105D pncA: p.G105R pncA: p.G105V pncA: p.G108E pncA: p.G124S pncA: p.G132C pncA: p.G132R pncA: p.G132V pncA: p.G162A pncA: p.G162V pncA: p.G16R pncA: p.G16V pncA: p.G17C pncA: p.G24V pncA: p.G55C pncA: p.G75V pncA: p.G78V pncA: p.H137D pncA: p.H42N pncA: p.H42Q pncA: p.H43P pncA: p.H43Q pncA: p.H51D pncA: p.H51L pncA: p.H51N pncA: p.H57L pncA: p.H57N pncA: p.H71L pncA: p.H71N pncA: p.H82L pncA: p.I133F pncA: p.I133N pncA: p.I31F pncA: p.I31N pncA: p.I31T pncA: p.I52T pncA: p.I5F pncA: p.I5M pncA: p.I5N pncA: p.I6F pncA: p.I6M pncA: p.K48Ter pncA: p.K48T pncA: p.K96Ter pncA: p.L116Q pncA: p.L117Q pncA: p.L120Q pncA: p.L151Ter pncA: p.L156P pncA: p.L156R pncA: p.L159Q pncA: p.L19Q pncA: p.L27Q pncA: p.L35P pncA: p.L4Ter pncA: p.L4F pncA: p.L4V pncA: p.L85Q pncA: p.M175K pncA: p.M1L pncA: p.N112S pncA: p.A134P pncA: p.N118Y pncA: p.N11T pncA: p.N149I pncA: p.N149Y pncA: p.P115A pncA: p.P115R pncA: p.P54R pncA: p.P62A pncA: p.A143D pncA: p.P62R pncA: p.P69L pncA: p.P69Q pncA: p.P70A pncA: p.P70S pncA: p.P77S pncA: p.Q10Ter pncA: p.Q10E pncA: p.Q10H pncA: p.Q10L pncA: p.Q122Ter pncA: p.Q122K pncA: p.R123S pncA: p.R140P pncA: p.R154M pncA: p.R176P pncA: p.R29C pncA: p.A146S pncA: p.S164T pncA: p.S179N pncA: p.S18Ter pncA: p.S186F pncA: p.S18L pncA: p.S18T pncA: p.S32N pncA: p.S59F pncA: p.S65F pncA: p.S66Ter pncA: p.S67Ter pncA: p.S88Ter pncA: p.S88T pncA: p.T114A pncA: p.T135I pncA: p.T135S pncA: p.A152V pncA: p.T142R pncA: p.T153N pncA: p.T160K pncA: p.T160R pncA: p.T22I pncA: p.T76S pncA: p.V109L pncA: p.V125A pncA: p.V128A pncA: p.V128D pncA: p.V130E pncA: p.V131D pncA: p.V131F pncA: p.V131I pncA: p.A165D pncA: p.V139E pncA: p.V147A pncA: p.V155E pncA: p.V155M pncA: p.V163E pncA: p.V180D pncA: p.V183D pncA: p.V21A pncA: p.A170S pncA: p.V21E pncA: p.V44D pncA: p.V7A pncA: p.V93E pncA: p.V93L pncA: p.W119Ter pncA: p.W119G pncA: p.W119L pncA: p.A170V pncA: p.W68Ter pncA: p.Y41Ter pncA: p.Y64Ter pncA: p.Y95Ter pncA: p.A26V pncA: p.A28S pncA: p.A30P pncA: p.A30S pncA: p.A30V pncA: p.A36D pncA: p.A36S pncA: p.A38G pncA: p.A38S pncA: p.A46P pncA: p.A79P pncA: p.A89V pncA: p.A92E pncA: p.C138Ter pncA: p.C138F pncA: p.C138G pncA: p.C14Ter pncA: p.C14W pncA: p.C184R pncA: p.C72Ter pncA: p.C72F pncA: p.C72Y pncA: p.D110E pncA: p.D110H pncA: p.D110N pncA: p.D129E pncA: p.D12H pncA: p.D12Y pncA: p.D136V pncA: p.D145E pncA: p.D158G pncA: p.D166V pncA: p.D49E pncA: p.D49H pncA: p.D49Y pncA: p.D63E pncA: p.D63Y pncA: p.D80H pncA: p.D86V pncA: p.D8A pncA: p.D8V pncA: p.E111Ter pncA: p.E127Ter pncA: p.E127D pncA: p.E144Ter pncA: p.E15Ter pncA: p.E173Ter pncA: p.E173G pncA: p.E174K pncA: p.E181Ter pncA: p.E181K

Protein Change: A134V, A146E, A146V, A161P, A171T, A3E, A46E, A46V, C138R, C138S, C138Y, C14R, C14Y, C72R, C72W, D12A, D12E, D12N, D136H, D136N, D136Y, D49G, D49N, D49V, D63G, D63H, D8E, D8G, D8H, D8N, D8Y, E174G, F58L, F58S, G108Ter, G132S, G17D, G23V, G78D, G97S, H137P, H137R, H51Q, H51R, H51Y, H57D, H57Q, H57R, H71R, H82R, I133T, I5T, I6T, K96E, K96M, K96N, K96Q, L116R, L151S, L172P, L19P, L27P, L4S, L4W, L85P, L85R, M175V, P54L, P54T, P62S, Q10P, Q10R, Q141P, S104C, S164Ter, S164P, S66P, S67P, T135P, T142K, T142M, T160P, T47A, T47S, T76I, T76P, V125D, V128G, V139A, V139G, V139L, V139M, V155G, V180F, V180G, V7D, V7F, V7G, W119R, W68C, W68G, W68L, W68R, Y103Ter, Y103H, Y34D, Y41H, F81V, G78C, G97R, K48E, L159V, A171E, P54Q, D12G, Q141Ter, S104G, S32I, F94L, F94S, G108R, G132A, G132D, G162D, G24D, G97C, G97D, T114P, H57P, H57Y, H71D, H71Q, H71Y, K96R, K96T, L116P, L120P, L159P, M175I, M175T, V21G, P54S, P62L, P62Q, V7L, Y99Ter, R123P, S104R, S59P, T135N, T142A, T168P, V125F, V125G, E37Ter, E91Ter, F106S, F106Y, F13I, F13V, F13Y, F58I, F81S, F94C, G101Ter, G101E, G105D, G105R, G105V, G108E, G124S, G132C, G132R, G132V, G162A, G162V, G16R, G16V, G17C, G24V, G55C, G75V, G78V, H137D, H42N, H42Q, H43P, H43Q, H51D, H51L, H51N, H57L, H57N, H71L, H71N, H82L, I133F, I133N, I31F, I31N, I31T, I52T, I5F, I5M, I5N, I6F, I6M, K48Ter, K48T, K96Ter, L116Q, L117Q, L120Q, L151Ter, L156P, L156R, L159Q, L19Q, L27Q, L35P, L4Ter, L4F, L4V, L85Q, M175K, M1L, N112S, A134P, N118Y, N11T, N149I, N149Y, P115A, P115R, P54R, P62A, A143D, P62R, P69L, P69Q, P70A, P70S, P77S, Q10Ter, Q10E, Q10H, Q10L, Q122Ter, Q122K, R123S, R140P, R154M, R176P, R29C, A146S, S164T, S179N, S18Ter, S186F, S18L, S18T, S32N, S59F, S65F, S66Ter, S67Ter, S88Ter, S88T, T114A, T135I, T135S, A152V, T142R, T153N, T160K, T160R, T22I, T76S, V109L, V125A, V128A, V128D, V130E, V131D, V131F, V131I, A165D, V139E, V147A, V155E, V155M, V163E, V180D, V183D, V21A, A170S, V21E, V44D, V7A, V93E, V93L, W119Ter, W119G, W119L, A170V, W68Ter, Y41Ter, Y64Ter, Y95Ter, A26V, A28S, A30P, A30S, A30V, A36D, A36S, A38G, A38S, A46P, A79P, A89V, A92E, C138Ter, C138F, C138G, C14Ter, C14W, C184R, C72Ter, C72F, C72Y, D110E, D110H, D110N, D129E, D12H, D12Y, D136V, D145E, D158G, D166V, D49E, D49H, D49Y, D63E, D63Y, D80H, D86V, D8A, D8V, E111Ter, E127Ter, E127D, E144Ter, E15Ter, E173Ter, E173G, E174K, E181Ter, E181K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant; nonsense mutation
Source Database: Card Database

150

Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.

PMID 10471589 · 1999

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.H137P pncA: p.D136H pncA: p.A171V pncA: p.H51Y pncA: p.P62H pncA: p.A171T pncA: p.L172A

Protein Change: H137P, D136H, A171V, H51Y, P62H, A171T, L172A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

151

Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

PMID 9692180 · 1997

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.G17D pncA: p.Y34S

Protein Change: G17D, Y34S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

152

Pyrazinamide-monoresistant Mycobacterium tuberculosis in the United States.

PMID 11158123 · 2001

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.I90S pncA: p.S104C

Protein Change: I90S, S104C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

153

Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.

PMID 28697808 · 2017

Mutations in pncA were found in all 33 isolates that were identified as PZA resistant by DST.

Mutation Information

pncA: c.448insG pncA: p.D49A / c.A146C pncA: p.I6L / c.A16C pncA: p.D63A / c.A188C pncA: p.H71P / c.A212C pncA: p.H71R / c.A212G pncA: p.Q141P / c.A422C pncA: p.H71Y / c.C211T pncA: p.T142M / c.C425T pncA: p.W68C / c.G204T pncA: p.W119L / c.G356T pncA: p.C14Y / c.G41A pncA: p.I5T / c.T14C pncA: p.V7A / c.T20C pncA: p.L85R / c.T254G pncA: p.V130G / c.T389G pncA: p.C14R / c.T40C pncA: p.C138R / c.T412C

Protein Change: D49A, I6L, D63A, H71P, H71R, Q141P, H71Y, T142M, W68C, W119L, C14Y, I5T, V7A, L85R, V130G, C14R, C138R
Nucleotide Change: 448insG, A146C, A16C, A188C, A212C, A212G, A422C, C211T, C425T, G204T, G356T, G41A, T14C, T20C, T254G, T389G, T40C, T412C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Sanger sequencing and phenotypic susceptibility testing
Source Database: Reslit

154

Role of pncA and rpsA gene sequencing in detection of pyrazinamide resistance in Mycobacterium tuberculosis isolates from southern China.

PMID 24131688 · 2014

Mutation Information

pncA: c.A-11C pncA: c.A-11G

Nucleotide Change: A-11C, A-11G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Source Database: ResFinder Database

155

Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.

PMID 22825123 · 2012

Mutation Information

pncA: c.A-11C pncA: c.A-11G pncA: c.T-10C pncA: c.T-7C

Nucleotide Change: A-11C, A-11G, T-10C, T-7C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Source Database: ResFinder Database

156

Tuberculosis drug resistance mutation database.

PMID 19209951 · 2009

Mutation Information

Nucleotide Change: A-11C, A-11G, T-12C, T-12G, T-7C, del158A, del161C, del162G, del172T, del239A, del288G, del28C, del307TACAG, del312C, del341C, del381GG, del386ATGT, del391G, del406G, del416TG, del436G, del443G, del452T, del475C, del47G, del512C, del59C, del64A, del70G, del71G, del84C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Source Database: ResFinder Database

157

Rapid detection of Mycobacterium tuberculosis and pyrazinamide susceptibility related to pncA mutations in sputum specimens through an integrated gene-to-protein function approach.

PMID 24226918 · 2014

Mutation Information

pncA: c.A-11G pncA: c.A521G pncA: c.C151G pncA: c.C89A

Nucleotide Change: A-11G, A521G, C151G, C89A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing and in vitro -synthesized-PZase assay
Source Database: Reslit

158

Prevalence and molecular characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates from Southern China.

PMID 29110640 · 2017

mutations in pncA gene contribute to pyrazinamide resistance

Mutation Information

pncA: c.A-11G

Nucleotide Change: A-11G
Organisms: Mycobacterium tuberculosis
Effect on Function: loss of pncA expression
Validation Method: sequence analysis
Source Database: Reslit

159

Whole genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates collected in the Czech Republic, 2005-2020.

PMID 35505072 · 2022

Mutation Information

pncA: c.A12A pncA: c.A49G pncA: c.A63A pncA: c.C138T pncA: c.G97A pncA: c.T142A pncA: c.T160A pncA: c.T68G

Nucleotide Change: A12A, A49G, A63A, C138T, G97A, T142A, T160A, T68G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing data
Source Database: Reslit

160

Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation.

PMID 30606210 · 2019

Mutation Information

pncA: p.T47P / c.A139C pncA: p.S18* / c.C53A pncA: p.L85R / c.T254G

Protein Change: T47P, S18*, L85R
Nucleotide Change: A139C, C53A, T254G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: sequencing and phenotypic correlation
Source Database: Reslit

161

Phenotypic characterization of pncA mutants of Mycobacterium tuberculosis.

PMID 10952570 · 2000

includes various types of mutations

Mutation Information

pncA: p.T47A / c.A139G pncA: c.T-7C

Protein Change: T47A
Nucleotide Change: A139G, T-7C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing and PZase activity testing
Source Database: Reslit

162

Whole Genome Sequencing of Mycobacterium tuberculosis under routine conditions in a high-burden area of multidrug-resistant tuberculosis in Peru.

PMID 38861531 · 2024

Mutation Information

pncA: p.K48T / c.A144G pncA: p.Q10R / c.C30T

Protein Change: K48T, Q10R
Nucleotide Change: A144G, C30T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

163

Whole genome sequencing of Mycobacterium tuberculosis isolates and clinical outcomes of patients treated for multidrug-resistant tuberculosis in Tanzania.

PMID 32085703 · 2020

Mutations in pncA gene associated with pyrazinamide resistance.

Mutation Information

pncA: p.D49G / c.A147G pncA: p.Q10R / c.A31G pncA: p.A46V / c.C138T pncA: p.P69L / c.CCG->CTT pncA: p.D8N / c.G23A pncA: p.G17D / c.G51A pncA: p.D63A / c.GAT->GCA pncA: c.GCC->ACT pncA: p.V128G / c.GTG->GGA pncA: p.L85P / c.TTG->CCC

Protein Change: D49G, Q10R, A46V, P69L, D8N, G17D, D63A, V128G, L85P
Nucleotide Change: A147G, A31G, C138T, CCG->CTT, G23A, G51A, GAT->GCA, GCC->ACT, GTG->GGA, TTG->CCC
Confers Resistance To: pza
Validation Method: whole genome sequencing
Source Database: Reslit

164

Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages.

PMID 34422898 · 2021

associated with high odds ratio

Mutation Information

pncA: p.D49G / c.A148G pncA: p.D8G / c.A25G pncA: p.Q10P / c.A31C pncA: p.A134D / c.C403A pncA: p.H51D / c.CAG->GAT pncA: p.A134P / c.G402C pncA: p.G162D / c.G487A pncA: p.D49A / c.GAT->GCA pncA: p.D8A / c.GAT->GCA pncA: p.Y103D / c.T309G pncA: p.C138R / c.T414C

Protein Change: D49G, D8G, Q10P, A134D, H51D, A134P, G162D, D49A, D8A, Y103D, C138R
Nucleotide Change: A148G, A25G, A31C, C403A, CAG->GAT, G402C, G487A, GAT->GCA, T309G, T414C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: in silico predictions and GWAS analysis
Source Database: Reslit

165

Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan.

PMID 30728001 · 2019

Mutations in the pncA gene were identified in PZA-resistant isolates.

Mutation Information

Protein Change: H57P, H71R, T76P, K96Q, D12A, Q141P, S179C, A46V, P54L, P69T, H71Y, N11K, A146V, S18*, R123P, D126N, D129N, V131F, R140H, E144K, G150A, R154T, A170P, E173E, V180F, W68R, L120R, V157G, L19R
Nucleotide Change: A170C, A212G, A226C, A286C, A35C, A422C, A535G, C137T, C161T, C205A, C211T, C33A, C437T, C53A, G331T, G368C, G376A, G385A, G391T, G419A, G430A, G449C, G461C, G508C, G519A, G538T, T202C, T359G, T398C, T470G, T56G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

166

Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.

PMID 39731145 · 2024

Mutation Information

pncA: p.N76H / c.A226C pncA: p.K114R / c.A340G pncA: p.N137S / c.A410G pncA: p.P46Q / c.C137A pncA: p.G37V / c.G109T pncA: p.G136D / c.G406A pncA: p.F68R / c.T202G pncA: p.L85R / c.T254G pncA: p.L13P / c.T38C

Protein Change: N76H, K114R, N137S, P46Q, G37V, G136D, F68R, L85R, L13P
Nucleotide Change: A226C, A340G, A410G, C137A, G109T, G406A, T202G, T254G, T38C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: nanopore sequencing
Source Database: Reslit

167

Tuberculosis due to resistant Haarlem strain, Tunisia.

PMID 15963297 · 2005

Mutation Information

pncA: c.A33G

Nucleotide Change: A33G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing
Source Database: Reslit

168

A Novel Molecular Strategy for Surveillance of Multidrug Resistant Tuberculosis in High Burden Settings.

PMID 26752297 · 2016

Mutations in pncA are associated with pyrazinamide resistance.

Mutation Information

pncA: p.R154G / c.A460G pncA: p.S67W / c.C200G pncA: p.H71Y / c.C211T pncA: p.A102V / c.C305T pncA: p.A134D / c.C401A pncA: p.G97D / c.G289A pncA: p.G97C / c.G289T pncA: p.G132A / c.G395C pncA: p.Y34D / c.T100G pncA: p.S59P / c.T175C pncA: p.C14R / c.T40C pncA: p.V139G / c.T416G pncA: p.L151S / c.T452C

Protein Change: R154G, S67W, H71Y, A102V, A134D, G97D, G97C, G132A, Y34D, S59P, C14R, V139G, L151S
Nucleotide Change: A460G, C200G, C211T, C305T, C401A, G289A, G289T, G395C, T100G, T175C, T40C, T416G, T452C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing and alignment to MTB H37Rv reference strain
Source Database: Reslit

169

In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment.

PMID 30157763 · 2018

Mutation Information

pncA: c.A87T

Nucleotide Change: A87T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genomic sequencing
Source Database: Reslit

170

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe.

PMID 30348088 · 2018

Mutation Information

pncA: c.C-11T pncA: c.C-128T pncA: c.C-159T pncA: c.C-34T pncA: c.C-7T pncA: c.C160T pncA: c.G13A

Nucleotide Change: C-11T, C-128T, C-159T, C-34T, C-7T, C160T, G13A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic resistance profile
Source Database: Reslit

171

Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools.

PMID 28425484 · 2017

This mutation was identified in strains resistant to pyrazinamide.

Mutation Information

pncA: p.H57D / c.C170G

Protein Change: H57D
Nucleotide Change: C170G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Sanger sequencing and phenotypic DST
Source Database: Reslit

172

MODS-Wayne, a Colorimetric Adaptation of the Microscopic-Observation Drug Susceptibility (MODS) Assay for Detection of Mycobacterium tuberculosis Pyrazinamide Resistance from Sputum Samples.

PMID 30429257 · 2019

Mutation Information

pncA: p.Q10P / c.C30T

Protein Change: Q10P
Nucleotide Change: C30T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: comparison with composite reference standard
Source Database: Reslit

173

Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages.

PMID 39730579 · 2024

Mutations in pncA are associated with pyrazinamide resistance in MDR and pre-XDR strains.

Mutation Information

pncA: p.R106K / c.C317T

Protein Change: R106K
Nucleotide Change: C317T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic resistance profiling
Source Database: Reslit

174

Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis.

PMID 29404424 · 2018

major PZA resistance mutation

Mutation Information

pncA: p.A156G / c.C468G

Protein Change: A156G
Nucleotide Change: C468G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole-genome sequencing
Source Database: Reslit

175

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

PMID 32055708 · 2019

Variants R188Q and G176D in pncA gene cause resistance to pyrazinamide.

Mutation Information

pncA: p.R188Q / c.CGG->CAA pncA: p.G176D / c.GGT->GAT

Protein Change: R188Q, G176D
Nucleotide Change: CGG->CAA, GGT->GAT
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: cloning in E. coli + disk diffusion
Source Database: Reslit

176

Drug resistance and genomic variations among Mycobacterium tuberculosis isolates from The Nile Delta, Egypt.

PMID 39223176 · 2024

Mutation Information

pncA: c.G-33A

Nucleotide Change: G-33A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing
Source Database: Reslit

177

MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.

PMID 24731071 · 2014

Mutation Information

pncA: p.G36D / c.G106A pncA: c.del118GACTACCATCACGTCGTGGCAACCAAGGACTTC pncA: c.del158A pncA: c.del161C pncA: c.del162G pncA: c.del172T pncA: c.del1ATGCGGGC pncA: c.del1ATGCGGGCGTT pncA: c.del239A pncA: c.del288G pncA: c.del28C pncA: c.del307TACAG pncA: c.del312C pncA: c.del341C pncA: c.del379GAGGTCGATGT pncA: c.del381GG pncA: c.del386ATGT pncA: c.del391G pncA: c.del395GTATTGCCACC pncA: c.del406G pncA: c.del416TG pncA: c.del436G pncA: c.del443G pncA: c.del446ATGGCTTG pncA: c.del452T pncA: c.del475C pncA: c.del47G pncA: c.del512C pncA: c.del59C pncA: c.del64A pncA: c.del70G pncA: c.del71G pncA: c.del84C pncA: c.del88GCCATCAGCGACTACCTGGCCGAA pncA: c.ins101T pncA: c.ins137G pncA: c.ins163T pncA: c.ins193A pncA: c.ins219CGCATTGCCG pncA: c.ins222G pncA: c.ins288T pncA: c.ins302A pncA: c.ins302G pncA: c.ins307C pncA: c.ins369AG pncA: c.ins369NNNNNNNNNNNNNNNNNN pncA: c.ins383AG pncA: c.ins389AGGTCGATG pncA: c.ins389GAGGTCGAT pncA: c.ins392GG pncA: c.ins393G pncA: c.ins398T pncA: c.ins404C pncA: c.ins408C pncA: c.ins415G pncA: c.ins421G pncA: c.ins421GG pncA: c.ins429GG pncA: c.ins466T pncA: c.ins481TGAC pncA: c.ins502GC pncA: c.ins519NNNNN pncA: c.ins533C pncA: c.ins53GG

Protein Change: G36D
Nucleotide Change: G106A, del118GACTACCATCACGTCGTGGCAACCAAGGACTTC, del158A, del161C, del162G, del172T, del1ATGCGGGC, del1ATGCGGGCGTT, del239A, del288G, del28C, del307TACAG, del312C, del341C, del379GAGGTCGATGT, del381GG, del386ATGT, del391G, del395GTATTGCCACC, del406G, del416TG, del436G, del443G, del446ATGGCTTG, del452T, del475C, del47G, del512C, del59C, del64A, del70G, del71G, del84C, del88GCCATCAGCGACTACCTGGCCGAA, ins101T, ins137G, ins163T, ins193A, ins219CGCATTGCCG, ins222G, ins288T, ins302A, ins302G, ins307C, ins369AG, ins369NNNNNNNNNNNNNNNNNN, ins383AG, ins389AGGTCGATG, ins389GAGGTCGAT, ins392GG, ins393G, ins398T, ins404C, ins408C, ins415G, ins421G, ins421GG, ins429GG, ins466T, ins481TGAC, ins502GC, ins519NNNNN, ins533C, ins53GG
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: systematic review of literature
Source Database: ReslitResFinder Database

178

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.

PMID 31234910 · 2019

Mutation Information

pncA: c.G332A

Nucleotide Change: G332A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole genome sequencing and drug susceptibility testing
Source Database: Reslit

179

A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection.

PMID 40552123 · 2025

missed by TB Pro assay

Mutation Information

pncA: p.R112H / c.G336A

Protein Change: R112H
Nucleotide Change: G336A
Organisms: Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium abscessus, Mycobacterium intracellulare, Mycobacterium kansasii, Mycobacterium malmoense, Mycobacterium xenopi, Mycobacterium marinum, Mycobacterium fortuitum
Confers Resistance To: pyrazinamide
Validation Method: comparison with WGS
Source Database: Reslit

180

Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.

PMID 38384306 · 2024

Mutation Information

pncA: p.V139L / c.G417T

Protein Change: V139L
Nucleotide Change: G417T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: whole_genome_sequencing
Source Database: Reslit

181

Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.

PMID 32573374 · 2020

Mutation Information

pncA: p.G171A / c.G514A

Protein Change: G171A
Nucleotide Change: G514A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: Experimental data from the study
Source Database: Reslit

182

Pontine control of the urinary bladder and external urethral sphincter in the rat.

PMID 2282512 · 1990

Mutation Information

pncA: c.T-12C pncA: c.T-12G

Nucleotide Change: T-12C, T-12G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Source Database: ResFinder Database

183

Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan.

PMID 19832709 · 2010

Mutation Information

pncA: c.T-7C

Nucleotide Change: T-7C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Source Database: ResFinder Database

184

Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity.

PMID 30010947 · 2018

Mutation Information

pncA: c.T103G

Nucleotide Change: T103G
Organisms: Mycobacterium africanum
Confers Resistance To: pyrazinamide
Validation Method: DNA sequencing and phenotypic drug susceptibility testing
Source Database: Reslit

185

Direct Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis by Use of pncA PCR Sequencing.

PMID 31189582 · 2019

Mutation Information

pncA: c.T12C

Nucleotide Change: T12C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: pncA sequencing and PZase activity assay
Source Database: Reslit

186

Whole Genome Sequencing of Drug Resistant and Drug Susceptible Mycobacterium tuberculosis Isolates From Tigray Region, Ethiopia.

PMID 34938276 · 2021

associated with pyrazinamide resistance

Mutation Information

pncA: p.V139A / c.T419C

Protein Change: V139A
Nucleotide Change: T419C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pza
Validation Method: whole-genome sequencing
Source Database: Reslit

187

Anti-tuberculosis drug resistance in Slovakia, 2018-2019: The first whole-genome epidemiological study.

PMID 35005254 · 2022

Mutation Information

pncA: c.T546C

Nucleotide Change: T546C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: genotypic drug susceptibility testing (gDST)
Source Database: Reslit

188

Insights into Pyrazinamidase and DNA Gyrase Protein Structures in Resistant and Susceptible Clinical Isolates of Mycobacterium tuberculosis.

PMID 28210279 · 2016

This mutation was considered a polymorphism and not linked to resistance.

Mutation Information

pncA: p.I31T / c.T92C

Protein Change: I31T
Nucleotide Change: T92C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

189

Differences in transneuronal transport of horseradish peroxidase conjugated wheat germ agglutinin in the visual system: marmoset monkey and guinea pig compared.

PMID 2473107 · 1989

Mutation Information

pncA: c.del1ATGCGGGC pncA: c.del1ATGCGGGCGTT pncA: c.ins302A pncA: c.ins302G pncA: c.ins369AG pncA: c.ins369NNNNNNNNNNNNNNNNNN pncA: c.ins389AGGTCGATG pncA: c.ins389GAGGTCGAT pncA: c.ins421G pncA: c.ins421GG

Nucleotide Change: del1ATGCGGGC, del1ATGCGGGCGTT, ins302A, ins302G, ins369AG, ins369NNNNNNNNNNNNNNNNNN, ins389AGGTCGATG, ins389GAGGTCGAT, ins421G, ins421GG
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Source Database: ResFinder Database

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