ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeY103D

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 3

Paper Information3

Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages.

PMID 34422898 · 2021

associated with high odds ratio

Mutation Information

pncA: p.Y103D / c.T309G

Protein Change: Y103D
Nucleotide Change: T309G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: in silico predictions and GWAS analysis
Source Database: Reslit

A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.

PMID 29906261 · 2018

Mutation Information

pncA: p.Y103D

Protein Change: Y103D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

PMID 978-92-4-008241-0

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.Y103D

Protein Change: Y103D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

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