Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

GenepncA

Protein ChangeV131F

Nucleotide ChangeG391T

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 3

Paper Information3

1

Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan.

PMID 30728001 · 2019

Mutations in the pncA gene were identified in PZA-resistant isolates.

Mutation Information

pncA: p.V131F / c.G391T

Protein Change: V131F
Nucleotide Change: G391T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: sequencing
Source Database: Reslit

2

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.

PMID 35944069 · 2022

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

Protein Change: V131F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

3

PMID 978-92-4-008241-0

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

Protein Change: V131F
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

Comments (0)

No comments yet. Be the first to comment!