ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeV155A

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: loss of PZAse activity, single resistance variant
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 2

Paper Information2

Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.

PMID 19963078 · 2010

All mutations are missense mutations in the pncA gene associated with pyrazinamide resistance.

Mutation Information

pncA: p.V155A

Protein Change: V155A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: loss of PZAse activity
Validation Method: analysis of clinical isolates
Source Database: Reslit

PMID 978-92-4-008241-0

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.V155A

Protein Change: V155A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

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