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Browse Mutations pncAR188Q

GenepncA

Protein ChangeR188Q

Nucleotide ChangeCGG->CAA

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.

PMID 32055708 · 2019

Variants R188Q and G176D in pncA gene cause resistance to pyrazinamide.

Mutation Information

pncA: p.R188Q / c.CGG->CAA

Protein Change: R188Q
Nucleotide Change: CGG->CAA
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Validation Method: cloning in E. coli + disk diffusion
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research