ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeL172A

Validation StatusEstablished

Databases

Card Database

Overview

Mechanism: single resistance variant
Resistance To: pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.

PMID 10471589 · 1999

Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394

Mutation Information

pncA: p.L172A

Protein Change: L172A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: pyrazinamide
Effect on Function: single resistance variant
Source Database: Card Database

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