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Browse Mutations gyrBN538K

GenegyrB

Protein ChangeN538K

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: confers resistance to moxifloxacin
Resistance To: moxifloxacin
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

New insights into fluoroquinolone resistance in Mycobacterium tuberculosis: functional genetic analysis of gyrA and gyrB mutations.

PMID 22761889 · 2012

Mutations in gyrB were analyzed for their impact on fluoroquinolone resistance.

Mutation Information

Protein Change: N538K
Organisms: Mycobacterium tuberculosis
Confers Resistance To: moxifloxacin
Effect on Function: confers resistance to moxifloxacin
Validation Method: MIC testing; transduction and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research